Synthesis and inhibitory activity of 1,3

Synthesis and inhibitory activity of 1,3

A series of 1,3-(adamantan-1(2)-yl)imidazolidine-2,4,5-triones and 1,1'-(alkane-1,n-diyl)bis[3-(adamantan-1-yl)imidazolidine-2,4,5-triones] was synthesized via cyclization of 1,3-bis[adamantan-1(2)-ylureas] and 1,1'-(alkyl-1,n-diyl)bis[3-(adamantan-1-yl)ureas] with oxalyl chloride under mi...

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Veröffentlicht in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2017-10, Vol.53 (10), p.1080
Hauptverfasser: D'yachenko, Vladimir S, Burmistrov, Vladimir V, Nishi, Kosuke, Kim, In-Hae, Butov, Gennady M
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Hydrolases
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container_issue 10
container_start_page 1080
container_title Chemistry of heterocyclic compounds (New York, N.Y. 1965)
container_volume 53
creator D'yachenko, Vladimir S
Burmistrov, Vladimir V
Nishi, Kosuke
Kim, In-Hae
Butov, Gennady M
description A series of 1,3-(adamantan-1(2)-yl)imidazolidine-2,4,5-triones and 1,1'-(alkane-1,n-diyl)bis[3-(adamantan-1-yl)imidazolidine-2,4,5-triones] was synthesized via cyclization of 1,3-bis[adamantan-1(2)-ylureas] and 1,1'-(alkyl-1,n-diyl)bis[3-(adamantan-1-yl)ureas] with oxalyl chloride under mild conditions with high yields. All synthesized compounds were tested in vitro as inhibitors of soluble human epoxide hydrolase. A number of compounds have high inhibitory activity (IC.sub.50 1.6-650 nM), which makes them promising inhibitors of soluble epoxide hydrolase.
doi_str_mv 10.1007/s10593-017-2174-x
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title Synthesis and inhibitory activity of 1,3
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