Synthesis of [beta]-cycloalkylglycosides of Muramyl Dipeptide

[beta]-Cyclooctyl-, [beta]-cyclodecyl-, and [beta]-cyclopentadecylglycosides of N-acetylmuramyl-L-alanyl-D-isoglutamine were prepared in yields of 39, 18, and 25%, respectively, (calculated for muramic acid) via the reaction of [beta]-cycloalkyl-4,6-O-isopropylidene-N-acetyl-D-muramic acids with the...

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Veröffentlicht in:Chemistry of natural compounds 2017-09, Vol.53 (5), p.929
Hauptverfasser: Zemlyakov, A. E, Tsikalova, V. N, Tsikalov, V. V
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description [beta]-Cyclooctyl-, [beta]-cyclodecyl-, and [beta]-cyclopentadecylglycosides of N-acetylmuramyl-L-alanyl-D-isoglutamine were prepared in yields of 39, 18, and 25%, respectively, (calculated for muramic acid) via the reaction of [beta]-cycloalkyl-4,6-O-isopropylidene-N-acetyl-D-muramic acids with the benzyl ester of L-Ala-D-iGln using the HOSu/DCC method followed by deprotection.
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title Synthesis of [beta]-cycloalkylglycosides of Muramyl Dipeptide
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