Blood Glucose Levels Regulate Pancreatic [beta]-Cell Proliferation during Experimentally-Induced and Spontaneous Autoimmune Diabetes in Mice

Background Type 1 diabetes mellitus is caused by immune-mediated destruction of pancreatic [beta]-cells leading to insulin deficiency, impaired intermediary metabolism, and elevated blood glucose concentrations. While at autoimmune diabetes onset a limited number of [beta]-cells persist, the cells&#...

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Veröffentlicht in:	PloS one 2009-03, Vol.4 (3), p.e4827
Hauptverfasser:	Pechhold, Klaus, Koczwara, Kerstin, Zhu, Xiaolong, Harrison, Victor S, Walker, Greg, Lee, Janet, Harlan, David M
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Autoimmunity Blood glucose Diabetes mellitus Pancreatic beta cells
Online-Zugang:	Volltext
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