Targeted Deletion of HIF-1[alpha] Gene in T Cells Prevents their Inhibition in Hypoxic Inflamed Tissues and Improves Septic Mice Survival

Background Sepsis patients may die either from an overwhelming systemic immune response and/or from an immunoparalysis-associated lack of anti-bacterial immune defence. We hypothesized that bacterial superantigen-activated T cells may be prevented from contribution into anti-bacterial response due t...

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Veröffentlicht in:	PloS one 2007-09, Vol.2 (9), p.e853
Hauptverfasser:	Thiel, Manfred, Caldwell, Charles C, Kreth, Simone, Kuboki, Satoshi, Chen, P, Smith, Patrick, Ohta, Akio, Lentsch, Alex B, Lukashev, Dmitry, Sitkovsky, Michail V
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antibacterial agents B cells Cytokines Genes Infection Prevention T cells
Online-Zugang:	Volltext
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