Synthesis and Cytotoxicity of Pinostrobin Hydrazone Derivatives

Synthesis and Cytotoxicity of Pinostrobin Hydrazone Derivatives

The corresponding hydrazones and thiosemicarbazones were synthesized via the reaction of pinostrobin hydrazone with carbonyl compounds (aromatic aldehydes, acetone) or alkyl(aryl)isothiocyanates, respectively. The new pinostrobin derivatives showed significant cytotoxicity (MTT-assay) against MT-4,...

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Veröffentlicht in:Chemistry of natural compounds 2015-05, Vol.51 (3), p.464-471
Hauptverfasser: Mukusheva, G. K., Zhanymkhanova, P. Zh, Turysbaeva, A. Sh, Pokrovskii, M. A., Shakirov, M. M., Pokrovskii, A. G., Shul’ts, E. E., Adekenov, S. M.
Format: Artikel
Sprache:eng
Schlagworte:
Medicine
Organic Chemistry
Pharmacy
Plant Sciences
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Zusammenfassung:The corresponding hydrazones and thiosemicarbazones were synthesized via the reaction of pinostrobin hydrazone with carbonyl compounds (aromatic aldehydes, acetone) or alkyl(aryl)isothiocyanates, respectively. The new pinostrobin derivatives showed significant cytotoxicity (MTT-assay) against MT-4, CEM-13, and U-937 human tumor cell models.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-015-1316-6