Circulating Angiogenic Factors and the Risk of Adverse Outcomes among Haitian Women with Preeclampsia
Objective Angiogenic factors are strongly associated with adverse maternal and fetal outcomes among women with preterm preeclampsia (PE) in developed countries. We evaluated the role of angiogenic factors and their relationship to adverse outcomes among Haitian women with PE. Material and Methods We...
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| creator | March, Melissa I Geahchan, Carl Wenger, Julia Raghuraman, Nandini Berg, Anders Haddow, Hamish Mckeon, Bri Ann Narcisse, Rulx David, Jean Louis Scott, Jennifer Thadhani, Ravi Karumanchi, S. Ananth Rana, Sarosh |
| description | Objective Angiogenic factors are strongly associated with adverse maternal and fetal outcomes among women with preterm preeclampsia (PE) in developed countries. We evaluated the role of angiogenic factors and their relationship to adverse outcomes among Haitian women with PE. Material and Methods We measured plasma antiangiogenic soluble fms-like tyrosine kinase 1 (sFlt1) and proangiogenic placental growth factor (PlGF) levels in women with PE (n=35) compared to controls with no hypertensive disorders (NHD) (n=43) among subjects with singleton pregnancies that delivered at Hospital Albert Schweitzer (HAS) in Haiti. We divided the preeclamptic women into two groups, early onset ([less than or equal to] 34 weeks) and late onset (>34 weeks) and examined relationships between sFlt1/PlGF ratios on admission and adverse outcomes (abruption, respiratory complications, stroke, renal insufficiency, eclampsia, maternal death, birth weight |
| doi_str_mv | 10.1371/journal.pone.0126815 |
| format | Report |
| fullrecord | <record><control><sourceid>gale</sourceid><recordid>TN_cdi_gale_infotracacademiconefile_A431693328</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A431693328</galeid><sourcerecordid>A431693328</sourcerecordid><originalsourceid>FETCH-gale_infotracacademiconefile_A4316933283</originalsourceid><addsrcrecordid>eNqVjzFPwzAUhC0EUkvhH3R4f6DBjqlJx6ii6gZClTpWT85L-opjV7YDfx8PDKzohjt9uhtOiKWSldIv6ukSpujRVdfgqZKqNo1a34i52uh6ZWqpb__kmbhP6SLlWjfGzAVtOdrJYWY_QOsHDgN5trBDm0NMgL6DfCb44PQJoYe2-6KYCN6mbMNIpTCGstwjZ0YPx8I8fHM-w3sksg7Ha2J8EHc9ukSPv74Q1e71sN2vBnR0Yt-HHNEWdTSyLS96Lrx91spstK4b_e_BD6hlWBI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>report</recordtype></control><display><type>report</type><title>Circulating Angiogenic Factors and the Risk of Adverse Outcomes among Haitian Women with Preeclampsia</title><source>Public Library of Science (PLoS) Journals Open Access</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>March, Melissa I ; Geahchan, Carl ; Wenger, Julia ; Raghuraman, Nandini ; Berg, Anders ; Haddow, Hamish ; Mckeon, Bri Ann ; Narcisse, Rulx ; David, Jean Louis ; Scott, Jennifer ; Thadhani, Ravi ; Karumanchi, S. Ananth ; Rana, Sarosh</creator><creatorcontrib>March, Melissa I ; Geahchan, Carl ; Wenger, Julia ; Raghuraman, Nandini ; Berg, Anders ; Haddow, Hamish ; Mckeon, Bri Ann ; Narcisse, Rulx ; David, Jean Louis ; Scott, Jennifer ; Thadhani, Ravi ; Karumanchi, S. Ananth ; Rana, Sarosh</creatorcontrib><description>Objective Angiogenic factors are strongly associated with adverse maternal and fetal outcomes among women with preterm preeclampsia (PE) in developed countries. We evaluated the role of angiogenic factors and their relationship to adverse outcomes among Haitian women with PE. Material and Methods We measured plasma antiangiogenic soluble fms-like tyrosine kinase 1 (sFlt1) and proangiogenic placental growth factor (PlGF) levels in women with PE (n=35) compared to controls with no hypertensive disorders (NHD) (n=43) among subjects with singleton pregnancies that delivered at Hospital Albert Schweitzer (HAS) in Haiti. We divided the preeclamptic women into two groups, early onset ([less than or equal to] 34 weeks) and late onset (>34 weeks) and examined relationships between sFlt1/PlGF ratios on admission and adverse outcomes (abruption, respiratory complications, stroke, renal insufficiency, eclampsia, maternal death, birth weight <2500 grams, or fetal/neonatal death) in women with PE subgroups as compared to NHD groups separated by week of admission. Data are presented as median (25th-75th centile), n (%), and proportions. Results Among patients with PE, most (24/35) were admitted at term. Adverse outcome rates in PE were much higher among the early onset group compared to the late onset group (100.0% vs. 54.2%, P=0.007). Plasma angiogenic factors were dramatically altered in both subtypes of PE. Angiogenic factors also correlated with adverse outcomes in both subtypes of PE. The median sFlt1/PlGF ratios for subjects with early onset PE with any adverse outcome vs. NHD <=34 weeks with no adverse outcome were 703.1 (146.6, 1614.9) and 9.6 (3.5, 58.6); P34 weeks with no adverse outcome. Conclusion PE-related adverse outcomes are common in women in Haiti and are associated with profound angiogenic imbalance regardless of gestational age at presentation.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0126815</identifier><language>eng</language><publisher>Public Library of Science</publisher><subject>Care and treatment ; Comparative analysis ; Complications and side effects ; Health aspects ; Hypertension ; Patient outcomes ; Preeclampsia ; Pregnant women ; Risk factors ; Stroke</subject><ispartof>PLoS ONE, 2015, Vol.10 (5)</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>776,780,860,4476,27902</link.rule.ids></links><search><creatorcontrib>March, Melissa I</creatorcontrib><creatorcontrib>Geahchan, Carl</creatorcontrib><creatorcontrib>Wenger, Julia</creatorcontrib><creatorcontrib>Raghuraman, Nandini</creatorcontrib><creatorcontrib>Berg, Anders</creatorcontrib><creatorcontrib>Haddow, Hamish</creatorcontrib><creatorcontrib>Mckeon, Bri Ann</creatorcontrib><creatorcontrib>Narcisse, Rulx</creatorcontrib><creatorcontrib>David, Jean Louis</creatorcontrib><creatorcontrib>Scott, Jennifer</creatorcontrib><creatorcontrib>Thadhani, Ravi</creatorcontrib><creatorcontrib>Karumanchi, S. Ananth</creatorcontrib><creatorcontrib>Rana, Sarosh</creatorcontrib><title>Circulating Angiogenic Factors and the Risk of Adverse Outcomes among Haitian Women with Preeclampsia</title><title>PLoS ONE</title><description>Objective Angiogenic factors are strongly associated with adverse maternal and fetal outcomes among women with preterm preeclampsia (PE) in developed countries. We evaluated the role of angiogenic factors and their relationship to adverse outcomes among Haitian women with PE. Material and Methods We measured plasma antiangiogenic soluble fms-like tyrosine kinase 1 (sFlt1) and proangiogenic placental growth factor (PlGF) levels in women with PE (n=35) compared to controls with no hypertensive disorders (NHD) (n=43) among subjects with singleton pregnancies that delivered at Hospital Albert Schweitzer (HAS) in Haiti. We divided the preeclamptic women into two groups, early onset ([less than or equal to] 34 weeks) and late onset (>34 weeks) and examined relationships between sFlt1/PlGF ratios on admission and adverse outcomes (abruption, respiratory complications, stroke, renal insufficiency, eclampsia, maternal death, birth weight <2500 grams, or fetal/neonatal death) in women with PE subgroups as compared to NHD groups separated by week of admission. Data are presented as median (25th-75th centile), n (%), and proportions. Results Among patients with PE, most (24/35) were admitted at term. Adverse outcome rates in PE were much higher among the early onset group compared to the late onset group (100.0% vs. 54.2%, P=0.007). Plasma angiogenic factors were dramatically altered in both subtypes of PE. Angiogenic factors also correlated with adverse outcomes in both subtypes of PE. The median sFlt1/PlGF ratios for subjects with early onset PE with any adverse outcome vs. NHD <=34 weeks with no adverse outcome were 703.1 (146.6, 1614.9) and 9.6 (3.5, 58.6); P34 weeks with no adverse outcome. Conclusion PE-related adverse outcomes are common in women in Haiti and are associated with profound angiogenic imbalance regardless of gestational age at presentation.</description><subject>Care and treatment</subject><subject>Comparative analysis</subject><subject>Complications and side effects</subject><subject>Health aspects</subject><subject>Hypertension</subject><subject>Patient outcomes</subject><subject>Preeclampsia</subject><subject>Pregnant women</subject><subject>Risk factors</subject><subject>Stroke</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>report</rsrctype><creationdate>2015</creationdate><recordtype>report</recordtype><sourceid/><recordid>eNqVjzFPwzAUhC0EUkvhH3R4f6DBjqlJx6ii6gZClTpWT85L-opjV7YDfx8PDKzohjt9uhtOiKWSldIv6ukSpujRVdfgqZKqNo1a34i52uh6ZWqpb__kmbhP6SLlWjfGzAVtOdrJYWY_QOsHDgN5trBDm0NMgL6DfCb44PQJoYe2-6KYCN6mbMNIpTCGstwjZ0YPx8I8fHM-w3sksg7Ha2J8EHc9ukSPv74Q1e71sN2vBnR0Yt-HHNEWdTSyLS96Lrx91spstK4b_e_BD6hlWBI</recordid><startdate>20150512</startdate><enddate>20150512</enddate><creator>March, Melissa I</creator><creator>Geahchan, Carl</creator><creator>Wenger, Julia</creator><creator>Raghuraman, Nandini</creator><creator>Berg, Anders</creator><creator>Haddow, Hamish</creator><creator>Mckeon, Bri Ann</creator><creator>Narcisse, Rulx</creator><creator>David, Jean Louis</creator><creator>Scott, Jennifer</creator><creator>Thadhani, Ravi</creator><creator>Karumanchi, S. Ananth</creator><creator>Rana, Sarosh</creator><general>Public Library of Science</general><scope/></search><sort><creationdate>20150512</creationdate><title>Circulating Angiogenic Factors and the Risk of Adverse Outcomes among Haitian Women with Preeclampsia</title><author>March, Melissa I ; Geahchan, Carl ; Wenger, Julia ; Raghuraman, Nandini ; Berg, Anders ; Haddow, Hamish ; Mckeon, Bri Ann ; Narcisse, Rulx ; David, Jean Louis ; Scott, Jennifer ; Thadhani, Ravi ; Karumanchi, S. Ananth ; Rana, Sarosh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-gale_infotracacademiconefile_A4316933283</frbrgroupid><rsrctype>reports</rsrctype><prefilter>reports</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Care and treatment</topic><topic>Comparative analysis</topic><topic>Complications and side effects</topic><topic>Health aspects</topic><topic>Hypertension</topic><topic>Patient outcomes</topic><topic>Preeclampsia</topic><topic>Pregnant women</topic><topic>Risk factors</topic><topic>Stroke</topic><toplevel>online_resources</toplevel><creatorcontrib>March, Melissa I</creatorcontrib><creatorcontrib>Geahchan, Carl</creatorcontrib><creatorcontrib>Wenger, Julia</creatorcontrib><creatorcontrib>Raghuraman, Nandini</creatorcontrib><creatorcontrib>Berg, Anders</creatorcontrib><creatorcontrib>Haddow, Hamish</creatorcontrib><creatorcontrib>Mckeon, Bri Ann</creatorcontrib><creatorcontrib>Narcisse, Rulx</creatorcontrib><creatorcontrib>David, Jean Louis</creatorcontrib><creatorcontrib>Scott, Jennifer</creatorcontrib><creatorcontrib>Thadhani, Ravi</creatorcontrib><creatorcontrib>Karumanchi, S. Ananth</creatorcontrib><creatorcontrib>Rana, Sarosh</creatorcontrib></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>March, Melissa I</au><au>Geahchan, Carl</au><au>Wenger, Julia</au><au>Raghuraman, Nandini</au><au>Berg, Anders</au><au>Haddow, Hamish</au><au>Mckeon, Bri Ann</au><au>Narcisse, Rulx</au><au>David, Jean Louis</au><au>Scott, Jennifer</au><au>Thadhani, Ravi</au><au>Karumanchi, S. Ananth</au><au>Rana, Sarosh</au><format>book</format><genre>unknown</genre><ristype>RPRT</ristype><atitle>Circulating Angiogenic Factors and the Risk of Adverse Outcomes among Haitian Women with Preeclampsia</atitle><jtitle>PLoS ONE</jtitle><date>2015-05-12</date><risdate>2015</risdate><volume>10</volume><issue>5</issue><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Objective Angiogenic factors are strongly associated with adverse maternal and fetal outcomes among women with preterm preeclampsia (PE) in developed countries. We evaluated the role of angiogenic factors and their relationship to adverse outcomes among Haitian women with PE. Material and Methods We measured plasma antiangiogenic soluble fms-like tyrosine kinase 1 (sFlt1) and proangiogenic placental growth factor (PlGF) levels in women with PE (n=35) compared to controls with no hypertensive disorders (NHD) (n=43) among subjects with singleton pregnancies that delivered at Hospital Albert Schweitzer (HAS) in Haiti. We divided the preeclamptic women into two groups, early onset ([less than or equal to] 34 weeks) and late onset (>34 weeks) and examined relationships between sFlt1/PlGF ratios on admission and adverse outcomes (abruption, respiratory complications, stroke, renal insufficiency, eclampsia, maternal death, birth weight <2500 grams, or fetal/neonatal death) in women with PE subgroups as compared to NHD groups separated by week of admission. Data are presented as median (25th-75th centile), n (%), and proportions. Results Among patients with PE, most (24/35) were admitted at term. Adverse outcome rates in PE were much higher among the early onset group compared to the late onset group (100.0% vs. 54.2%, P=0.007). Plasma angiogenic factors were dramatically altered in both subtypes of PE. Angiogenic factors also correlated with adverse outcomes in both subtypes of PE. The median sFlt1/PlGF ratios for subjects with early onset PE with any adverse outcome vs. NHD <=34 weeks with no adverse outcome were 703.1 (146.6, 1614.9) and 9.6 (3.5, 58.6); P34 weeks with no adverse outcome. Conclusion PE-related adverse outcomes are common in women in Haiti and are associated with profound angiogenic imbalance regardless of gestational age at presentation.</abstract><pub>Public Library of Science</pub><doi>10.1371/journal.pone.0126815</doi></addata></record> |
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| source | Public Library of Science (PLoS) Journals Open Access; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Care and treatment Comparative analysis Complications and side effects Health aspects Hypertension Patient outcomes Preeclampsia Pregnant women Risk factors Stroke |
| title | Circulating Angiogenic Factors and the Risk of Adverse Outcomes among Haitian Women with Preeclampsia |
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