GMP production of .sup.68Ga-labelled DOTA-NOC on IBA Synthera

GMP production of .sup.68Ga-labelled DOTA-NOC on IBA Synthera

.sup.68Ga labelled peptides are increasingly being used clinically due to widespread availability of .sup.68Ge/.sup.68Ga generators and their recognised importance in the diagnosis of neuroendocrine tumours. A simple and reproducible GMP-compliant process for labelling peptides with generator-produc...

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Veröffentlicht in:Journal of radioanalytical and nuclear chemistry 2015-08, Vol.305 (2), p.501
Hauptverfasser: Alves, Vitor H, Prata, M. I. M, Abrunhosa, Antero J, Castelo-Branco, Miguel
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Peptides
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container_issue 2
container_start_page 501
container_title Journal of radioanalytical and nuclear chemistry
container_volume 305
creator Alves, Vitor H
Prata, M. I. M
Abrunhosa, Antero J
Castelo-Branco, Miguel
description .sup.68Ga labelled peptides are increasingly being used clinically due to widespread availability of .sup.68Ge/.sup.68Ga generators and their recognised importance in the diagnosis of neuroendocrine tumours. A simple and reproducible GMP-compliant process for labelling peptides with generator-produced .sup.68Ga is crucial to meet current pharmaceutical requirements. Here, we describe the development of a cassette-based .sup.68Ga-radiolabelling process using an automated commercial synthesizer coupled with a standard .sup.68Ge/.sup.68Ga generator. The radiolabeled somatostatin analogue [.sup.68Ga]DOTA-NOC was successfully synthesized in about 30 min with 80.3 ± 3.20 % of decay corrected radiochemical yield. The process is easily adaptable to the labelling of other peptides such as DOTA-TOC or DOTA-TATE for diagnosis or therapy.
doi_str_mv 10.1007/s10967-015-3989-5
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title GMP production of .sup.68Ga-labelled DOTA-NOC on IBA Synthera
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