Effect of nitroxyalkyl derivatives of fullerenylproline on the activity of [Ca.sup.3+]-atpase of sarcoplasmic reticulum
The effect of nitroxyalkyl derivatives of fullerenylproline methyl ester on the enzymatic activity of [Ca.sup.2+]-ATPase of sarcoplasmic reticulum (SR) has been studied. It is shown that hybrid derivatives of [C.sub.60] fullerene are capable of inhibiting the activity of [Ca.sup.2+]-ATPase of SR. Th...
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| Veröffentlicht in: | Pharmaceutical chemistry journal 2011-09, Vol.45 (6), p.329 |
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| creator | Tat'yanenko, L.V Dobrokhotova, O.V Kotel'nikova, R.A Poletayeva, D.A Mishchenko, D.V Pikhteleva, I. Yu Bogdanov, G.N Romanova, V.S Kotel'nikov, A.I |
| description | The effect of nitroxyalkyl derivatives of fullerenylproline methyl ester on the enzymatic activity of [Ca.sup.2+]-ATPase of sarcoplasmic reticulum (SR) has been studied. It is shown that hybrid derivatives of [C.sub.60] fullerene are capable of inhibiting the activity of [Ca.sup.2+]-ATPase of SR. The mononitrate inhibits the hydrolytic activity of the enzyme with [K.sub.i]=1.92 x 10 6 M; active [Ca.sup.2+] transport, with [K.sub.i] = 3.79 x 10 6 M. The dinitrate inhibits ATP hydrolysis with [K.sub.i] = 2.38 x 10 8 M; [Ca.sup.2+] transport, with [K.sub.i] = 3.08 x 10 8 M. Fullerenylproline methyl ester does not affect the enzymatic activity of [Ca.sup.2+]-ATPase. Based on these data it is possible to predict the possible fields of application for hybrid fullerene derivatives as potential drugs. Key words: [Ca.sup.2+]-[Mg.sup.2+]-ATPase of sarcoplasmic reticulum, phosphodiesterase of cyclic guanosine monophosphate, fullerenylproline nitrates. |
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Yu ; Bogdanov, G.N ; Romanova, V.S ; Kotel'nikov, A.I</creator><creatorcontrib>Tat'yanenko, L.V ; Dobrokhotova, O.V ; Kotel'nikova, R.A ; Poletayeva, D.A ; Mishchenko, D.V ; Pikhteleva, I. Yu ; Bogdanov, G.N ; Romanova, V.S ; Kotel'nikov, A.I</creatorcontrib><description>The effect of nitroxyalkyl derivatives of fullerenylproline methyl ester on the enzymatic activity of [Ca.sup.2+]-ATPase of sarcoplasmic reticulum (SR) has been studied. It is shown that hybrid derivatives of [C.sub.60] fullerene are capable of inhibiting the activity of [Ca.sup.2+]-ATPase of SR. The mononitrate inhibits the hydrolytic activity of the enzyme with [K.sub.i]=1.92 x 10 6 M; active [Ca.sup.2+] transport, with [K.sub.i] = 3.79 x 10 6 M. The dinitrate inhibits ATP hydrolysis with [K.sub.i] = 2.38 x 10 8 M; [Ca.sup.2+] transport, with [K.sub.i] = 3.08 x 10 8 M. Fullerenylproline methyl ester does not affect the enzymatic activity of [Ca.sup.2+]-ATPase. Based on these data it is possible to predict the possible fields of application for hybrid fullerene derivatives as potential drugs. Key words: [Ca.sup.2+]-[Mg.sup.2+]-ATPase of sarcoplasmic reticulum, phosphodiesterase of cyclic guanosine monophosphate, fullerenylproline nitrates.</description><identifier>ISSN: 0091-150X</identifier><language>eng</language><publisher>Springer</publisher><subject>Adenosine triphosphatase ; Hydrolysis</subject><ispartof>Pharmaceutical chemistry journal, 2011-09, Vol.45 (6), p.329</ispartof><rights>COPYRIGHT 2011 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Tat'yanenko, L.V</creatorcontrib><creatorcontrib>Dobrokhotova, O.V</creatorcontrib><creatorcontrib>Kotel'nikova, R.A</creatorcontrib><creatorcontrib>Poletayeva, D.A</creatorcontrib><creatorcontrib>Mishchenko, D.V</creatorcontrib><creatorcontrib>Pikhteleva, I. Yu</creatorcontrib><creatorcontrib>Bogdanov, G.N</creatorcontrib><creatorcontrib>Romanova, V.S</creatorcontrib><creatorcontrib>Kotel'nikov, A.I</creatorcontrib><title>Effect of nitroxyalkyl derivatives of fullerenylproline on the activity of [Ca.sup.3+]-atpase of sarcoplasmic reticulum</title><title>Pharmaceutical chemistry journal</title><description>The effect of nitroxyalkyl derivatives of fullerenylproline methyl ester on the enzymatic activity of [Ca.sup.2+]-ATPase of sarcoplasmic reticulum (SR) has been studied. It is shown that hybrid derivatives of [C.sub.60] fullerene are capable of inhibiting the activity of [Ca.sup.2+]-ATPase of SR. The mononitrate inhibits the hydrolytic activity of the enzyme with [K.sub.i]=1.92 x 10 6 M; active [Ca.sup.2+] transport, with [K.sub.i] = 3.79 x 10 6 M. The dinitrate inhibits ATP hydrolysis with [K.sub.i] = 2.38 x 10 8 M; [Ca.sup.2+] transport, with [K.sub.i] = 3.08 x 10 8 M. Fullerenylproline methyl ester does not affect the enzymatic activity of [Ca.sup.2+]-ATPase. Based on these data it is possible to predict the possible fields of application for hybrid fullerene derivatives as potential drugs. Key words: [Ca.sup.2+]-[Mg.sup.2+]-ATPase of sarcoplasmic reticulum, phosphodiesterase of cyclic guanosine monophosphate, fullerenylproline nitrates.</description><subject>Adenosine triphosphatase</subject><subject>Hydrolysis</subject><issn>0091-150X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqVi00KwjAQhbNQ8PcO2UtL2iDiUkTxAC4EERniREfHpCSp2tvbgheQt3jw3vf1xFCpZZEVc3UYiFGMd6UKpXQ5FO-NtWiS9FY6SsF_GuBHw_KCgV6Q6IWx-2zNjAFdw1XwTA6ldzLdUIJpGUpNBx3XkMe6yvXslEGqIGK3RgjGVwzxSUYGTGRqrp8T0bfAEae_Hot8u9mvd9kVGM_krE8BTJsLtp53aKndV3q-LBZludD6b-ELZkJV4Q</recordid><startdate>20110901</startdate><enddate>20110901</enddate><creator>Tat'yanenko, L.V</creator><creator>Dobrokhotova, O.V</creator><creator>Kotel'nikova, R.A</creator><creator>Poletayeva, D.A</creator><creator>Mishchenko, D.V</creator><creator>Pikhteleva, I. 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Yu ; Bogdanov, G.N ; Romanova, V.S ; Kotel'nikov, A.I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-gale_infotracacademiconefile_A3591722733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adenosine triphosphatase</topic><topic>Hydrolysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tat'yanenko, L.V</creatorcontrib><creatorcontrib>Dobrokhotova, O.V</creatorcontrib><creatorcontrib>Kotel'nikova, R.A</creatorcontrib><creatorcontrib>Poletayeva, D.A</creatorcontrib><creatorcontrib>Mishchenko, D.V</creatorcontrib><creatorcontrib>Pikhteleva, I. Yu</creatorcontrib><creatorcontrib>Bogdanov, G.N</creatorcontrib><creatorcontrib>Romanova, V.S</creatorcontrib><creatorcontrib>Kotel'nikov, A.I</creatorcontrib><jtitle>Pharmaceutical chemistry journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tat'yanenko, L.V</au><au>Dobrokhotova, O.V</au><au>Kotel'nikova, R.A</au><au>Poletayeva, D.A</au><au>Mishchenko, D.V</au><au>Pikhteleva, I. Yu</au><au>Bogdanov, G.N</au><au>Romanova, V.S</au><au>Kotel'nikov, A.I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of nitroxyalkyl derivatives of fullerenylproline on the activity of [Ca.sup.3+]-atpase of sarcoplasmic reticulum</atitle><jtitle>Pharmaceutical chemistry journal</jtitle><date>2011-09-01</date><risdate>2011</risdate><volume>45</volume><issue>6</issue><spage>329</spage><pages>329-</pages><issn>0091-150X</issn><abstract>The effect of nitroxyalkyl derivatives of fullerenylproline methyl ester on the enzymatic activity of [Ca.sup.2+]-ATPase of sarcoplasmic reticulum (SR) has been studied. It is shown that hybrid derivatives of [C.sub.60] fullerene are capable of inhibiting the activity of [Ca.sup.2+]-ATPase of SR. The mononitrate inhibits the hydrolytic activity of the enzyme with [K.sub.i]=1.92 x 10 6 M; active [Ca.sup.2+] transport, with [K.sub.i] = 3.79 x 10 6 M. The dinitrate inhibits ATP hydrolysis with [K.sub.i] = 2.38 x 10 8 M; [Ca.sup.2+] transport, with [K.sub.i] = 3.08 x 10 8 M. Fullerenylproline methyl ester does not affect the enzymatic activity of [Ca.sup.2+]-ATPase. Based on these data it is possible to predict the possible fields of application for hybrid fullerene derivatives as potential drugs. Key words: [Ca.sup.2+]-[Mg.sup.2+]-ATPase of sarcoplasmic reticulum, phosphodiesterase of cyclic guanosine monophosphate, fullerenylproline nitrates.</abstract><pub>Springer</pub></addata></record> |
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| title | Effect of nitroxyalkyl derivatives of fullerenylproline on the activity of [Ca.sup.3+]-atpase of sarcoplasmic reticulum |
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