Poly(vinyl pyrrolidone)–poloxamer-188 solid dispersions prepared by hot melt extrusion: Thermal properties and release behavior

Poly(vinyl pyrrolidone) (PVP)/poloxamer-188 blends were used as appropriate carriers for the preparation of solid dispersions by hot melt extrusion using aripiprazole (ARIP) as a poor water-soluble model drug. The physical state of ARIP in solid dispersions and its dissolution characteristics were t...

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Veröffentlicht in:	Journal of thermal analysis and calorimetry 2013-09, Vol.113 (3), p.1037-1047
Hauptverfasser:	Fousteris, Emmanouil, Tarantili, Petroula A., Karavas, Evangelos, Bikiaris, Dimitrios
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical Chemistry Biological and medical sciences Chemistry Chemistry and Materials Science General pharmacology Hydrogen Inorganic Chemistry Measurement Science and Instrumentation Medical sciences Neuropharmacology Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physical Chemistry Polymer Sciences Polymers Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Thermal properties
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