Rheological properties of an original pharmaceutical composition of a nanostructured silver system stabilized by arabinogalactan
Rheological properties of an original pharmaceutical composition of a nanostructured (ultradisperse) silver system stabilized by arabinogalactan were studied by dynamic rheology and compared with the official silver- containing preparation dermazin. Significant differences were observed in the rheol...
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| Veröffentlicht in: | Pharmaceutical chemistry journal 2013-05, Vol.47 (2), p.99-102 |
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| container_end_page | 102 |
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| container_issue | 2 |
| container_start_page | 99 |
| container_title | Pharmaceutical chemistry journal |
| container_volume | 47 |
| creator | Romanko, T. V. Kostyro, Ya. A. Gumennikova, E. N. Alekseev, K. V. Romanko, V. G. Grishchenko, L. A. Yes’kova, L. A. Ostroukhova, L. A. Babkin, V. A. Trofimov, B. A. |
| description | Rheological properties of an original pharmaceutical composition of a nanostructured (ultradisperse) silver system stabilized by arabinogalactan were studied by dynamic rheology and compared with the official silver- containing preparation dermazin. Significant differences were observed in the rheological characteristics of the soft dosage forms that affected their adherence to skin, the bioavailability of the active ingredients, and the production technology. It was established that the original pharmaceutical composition of the ultradisperse silver system stabilized by arabinogalactan was a structured liquid with clearly pronounced non-Newtonian flow characteristics that exhibited viscoplastic and thixotropic properties. Its rheological parameters corresponded well to requirements for the technical rheological optimum for extrusion of hydrophilic gels. |
| doi_str_mv | 10.1007/s11094-013-0904-7 |
| format | Article |
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It was established that the original pharmaceutical composition of the ultradisperse silver system stabilized by arabinogalactan was a structured liquid with clearly pronounced non-Newtonian flow characteristics that exhibited viscoplastic and thixotropic properties. 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Significant differences were observed in the rheological characteristics of the soft dosage forms that affected their adherence to skin, the bioavailability of the active ingredients, and the production technology. It was established that the original pharmaceutical composition of the ultradisperse silver system stabilized by arabinogalactan was a structured liquid with clearly pronounced non-Newtonian flow characteristics that exhibited viscoplastic and thixotropic properties. 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| ispartof | Pharmaceutical chemistry journal, 2013-05, Vol.47 (2), p.99-102 |
| issn | 0091-150X 1573-9031 |
| language | eng |
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| source | Springer Online Journals Complete |
| subjects | Medicine Organic Chemistry Pharmacology/Toxicology Pharmacy |
| title | Rheological properties of an original pharmaceutical composition of a nanostructured silver system stabilized by arabinogalactan |
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