Studies on quinazoline chemistry. 5. Synthesis of 3,4-dihydroquinazolines with functional substituents at C-2 atom and their alkylation reactions
Syntheses are reported for a new series of 2-substituted 4,4-diphenyl-3,4-dihydroquinazolines by the reaction of o-aminophenyldiphenylcarbinol (APC) with various nitriles. The reaction of APC with substituted 5-bromo-3-cyano-2(1H)-pyridones leads to the formation of derivatives of two products: 3,4-...
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| Veröffentlicht in: | Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2013, Vol.48 (10), p.1492-1502 |
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| container_title | Chemistry of heterocyclic compounds (New York, N.Y. 1965) |
| container_volume | 48 |
| creator | Gromachevskaya, E. V. Kaigorodova, E. A. Pushkareva, K. S. Krapivin, G. D. |
| description | Syntheses are reported for a new series of 2-substituted 4,4-diphenyl-3,4-dihydroquinazolines by the reaction of o-aminophenyldiphenylcarbinol (APC) with various nitriles. The reaction of APC with substituted 5-bromo-3-cyano-2(1H)-pyridones leads to the formation of derivatives of two products: 3,4-dihydroquinazolines and 4H-3,1-benzoxazines. The alkylation of 3,4-dihydroquinazolines using dimethyl sulfate proceeds through N,N-dimethylation. The structure of these products is a function of the nature of the substituent at C-2 atom of the heterocycle. |
| doi_str_mv | 10.1007/s10593-013-1163-y |
| format | Article |
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The structure of these products is a function of the nature of the substituent at C-2 atom of the heterocycle.</description><subject>Bisphenol-A</subject><subject>Chemical properties</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Organic Chemistry</subject><subject>Organic compounds</subject><subject>Pharmacy</subject><subject>Resveratrol</subject><subject>Sulfates</subject><issn>0009-3122</issn><issn>1573-8353</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp9kcFuHCEMhlHUSt2mfYDeeICyATwwwzFapUmkSDmkPSOGgSzJLDTAqJq8Rd-4bLeHnCofLNv_Z8n-EfrC6JZR2l8URoUCQhkQxiSQ9QxtmOiBDCDgHdpQShUBxvkH9LGUp1b2bOg26PdDXabgCk4Rvywhmtc0h-iw3btDKDWvWyy2-GGNde9KaDKP4WtHprBfp5zeEAX_CnWP_RJtDSmaGZdlLDXUxcVasKl4R3hL6YBNnHBbFzI28_M6m6MeZ2f-guUTeu_NXNznf_kc_fh29X13Q-7ur293l3fEAu8rkcaKkY90GJXx3HoKkxfe9b0BkOCplyNXSol-GDoFXFrFqFRGsK6b2mSAc7Q97X00s9Mh-lSzsS2mdrlN0fnQ-pcAQnIpO9oAdgJsTqVk5_XPHA4mr5pRfTRBn0zQzQR9NEGvjeEnpjRtfHRZP6Ult--U_0B_AL1_jPs</recordid><startdate>2013</startdate><enddate>2013</enddate><creator>Gromachevskaya, E. 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| subjects | Bisphenol-A Chemical properties Chemistry Chemistry and Materials Science Organic Chemistry Organic compounds Pharmacy Resveratrol Sulfates |
| title | Studies on quinazoline chemistry. 5. Synthesis of 3,4-dihydroquinazolines with functional substituents at C-2 atom and their alkylation reactions |
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