3-Alkyl-2-phenyl-1-vinylpyrroles from ketoximes and acetylene: an improved synthesis by the Trofimov reaction

A one-pot synthesis of 3-alkyl-2-phenyl-1-vinylpyrroles, giving high yields at atmospheric pressure, was developed on the basis of reacting alkyl phenyl ketoximes with acetylene in a KOH–DMSO system (the Trofimov reaction).

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Veröffentlicht in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2013-02, Vol.48 (11), p.1628-1633
Hauptverfasser: Petrova, O. V., Sobenina, L. N., Mikhaleva, A. I.
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container_issue 11
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container_title Chemistry of heterocyclic compounds (New York, N.Y. 1965)
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creator Petrova, O. V.
Sobenina, L. N.
Mikhaleva, A. I.
description A one-pot synthesis of 3-alkyl-2-phenyl-1-vinylpyrroles, giving high yields at atmospheric pressure, was developed on the basis of reacting alkyl phenyl ketoximes with acetylene in a KOH–DMSO system (the Trofimov reaction).
doi_str_mv 10.1007/s10593-013-1184-6
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subjects Acetylene
Chemistry
Chemistry and Materials Science
Organic Chemistry
Pharmacy
title 3-Alkyl-2-phenyl-1-vinylpyrroles from ketoximes and acetylene: an improved synthesis by the Trofimov reaction
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