Myeloma cells inhibit non-canonical wnt co-receptor ror2 expression in human bone marrow osteoprogenitor cells: effect of wnt5a/ror2 pathway activation on the osteogenic differentiation impairment induced by myeloma cells

Multiple myeloma (MM) is characterized by the impaired osteogenic differentiation of human mesenchymal stromal cells (hMSCs). Canonical Wnt signaling is critical for the regulation of bone formation, however, recent evidence suggests that the non-canonical Wnt agonist Wnt5a stimulates human osteobla...

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Veröffentlicht in:	Leukemia 2013, Vol.27 (2), p.451
Hauptverfasser:	Bolzoni, M, Donofrio, G, Sto, Guasco, D, Toscani, D, Lazzaretti, M, Bonomini, S, Agnelli, L, Capocefalo, A, Neri, A, Nicolini, F, Lisignoli, G, Russo, F, Colla, S, Aversa, F, Giuliani, N
Format:	Report
Sprache:	eng
Schlagworte:	Animal experimentation Bone marrow Cellular signal transduction Gene expression Multiple myeloma Physiological aspects
Online-Zugang:	Volltext
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