Statins as a novel therapeutic strategy in acute lung injury

Acute lung injury (ALI) is a devastating clinical condition associated with pulmonary and systemic inflammation and characterized by incompetence of the pulmonary microvascular barrier culminating in noncardiogenic pulmonary edema. An understanding of the mechanisms underlying endothelial barrier dy...

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Veröffentlicht in:	Pulmonary Circulation 2012-10, Vol.2 (4), p.397-406
Hauptverfasser:	Singla, Sunit, Jacobsen, Jeffrey R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins acute lung injury Acute respiratory distress syndrome Adult respiratory distress syndrome Animal models Cholesterols Dosage and administration Drug therapy Endothelium Gene expression Gene expression regulation Genetic aspects Inflammation Lung injury Lungs Nitric oxide Oxidases Physiological aspects pulmonary endothelium Review Review Article Statins Transcriptional regulatory elements
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