Statins as a novel therapeutic strategy in acute lung injury
Acute lung injury (ALI) is a devastating clinical condition associated with pulmonary and systemic inflammation and characterized by incompetence of the pulmonary microvascular barrier culminating in noncardiogenic pulmonary edema. An understanding of the mechanisms underlying endothelial barrier dy...
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| Veröffentlicht in: | Pulmonary Circulation 2012-10, Vol.2 (4), p.397-406 |
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| creator | Singla, Sunit Jacobsen, Jeffrey R. |
| description | Acute lung injury (ALI) is a devastating clinical condition associated with pulmonary and systemic inflammation and characterized by incompetence of the pulmonary microvascular barrier culminating in noncardiogenic pulmonary edema. An understanding of the mechanisms underlying endothelial barrier dysfunction in ALI has been facilitated by study of the effects of statins in relevant cellular and animals models. Many of the pleotropic properties of these drugs, including direct effects on endothelial cell (EC) cytoskeletal rearrangement, NADPH oxidase, and nitric oxide activity, as well as effects on differential EC gene expression, are relevant to the pathobiology of ALI and suggest a potential therapeutic role for statins in this context. Moreover, results from preclinical studies and observations in relevant patient populations support the protective potential of statins in ALI, paving the way now for definitive clinical trials. |
| doi_str_mv | 10.4103/2045-8932.105028 |
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An understanding of the mechanisms underlying endothelial barrier dysfunction in ALI has been facilitated by study of the effects of statins in relevant cellular and animals models. Many of the pleotropic properties of these drugs, including direct effects on endothelial cell (EC) cytoskeletal rearrangement, NADPH oxidase, and nitric oxide activity, as well as effects on differential EC gene expression, are relevant to the pathobiology of ALI and suggest a potential therapeutic role for statins in this context. Moreover, results from preclinical studies and observations in relevant patient populations support the protective potential of statins in ALI, paving the way now for definitive clinical trials.</description><identifier>ISSN: 2045-8932</identifier><identifier>ISSN: 2045-8940</identifier><identifier>EISSN: 2045-8940</identifier><identifier>DOI: 10.4103/2045-8932.105028</identifier><identifier>PMID: 23372924</identifier><language>eng</language><publisher>London, England: University of Chicago Press</publisher><subject>Actins ; acute lung injury ; Acute respiratory distress syndrome ; Adult respiratory distress syndrome ; Animal models ; Cholesterols ; Dosage and administration ; Drug therapy ; Endothelium ; Gene expression ; Gene expression regulation ; Genetic aspects ; Inflammation ; Lung injury ; Lungs ; Nitric oxide ; Oxidases ; Physiological aspects ; pulmonary endothelium ; Review ; Review Article ; Statins ; Transcriptional regulatory elements</subject><ispartof>Pulmonary Circulation, 2012-10, Vol.2 (4), p.397-406</ispartof><rights>2012 by the Pulmonary Vascular Research Institute. All rights reserved.</rights><rights>2012 SAGE Publications Ltd, or Pulmonary Vascular Research Institute, unless otherwise noted. Manuscript content on this site is licensed under Creative Commons Licenses</rights><rights>The Author(s)</rights><rights>COPYRIGHT 2012 Sage Publications Ltd. (UK)</rights><rights>2012 SAGE Publications Ltd, or Pulmonary Vascular Research Institute, unless otherwise noted. Manuscript content on this site is licensed under Creative Commons Licenses. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the associated terms available at: https://uk.sagepub.com/en-gb/eur/reusing-open-access-and-sage-choice-content</rights><rights>Copyright: © Pulmonary Circulation 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6142-cd56bf8a93445dcf1369c747cfd855b262b21105cdac84ca150b0ce5affa27603</citedby><cites>FETCH-LOGICAL-c6142-cd56bf8a93445dcf1369c747cfd855b262b21105cdac84ca150b0ce5affa27603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555410/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555410/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,313,314,727,780,784,792,885,1416,11560,25352,27920,27922,27923,45572,45573,46050,46474,53789,53791</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.4103%2F2045-8932.105028$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23372924$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Singla, Sunit</creatorcontrib><creatorcontrib>Jacobsen, Jeffrey R.</creatorcontrib><title>Statins as a novel therapeutic strategy in acute lung injury</title><title>Pulmonary Circulation</title><addtitle>Pulm Circ</addtitle><description>Acute lung injury (ALI) is a devastating clinical condition associated with pulmonary and systemic inflammation and characterized by incompetence of the pulmonary microvascular barrier culminating in noncardiogenic pulmonary edema. An understanding of the mechanisms underlying endothelial barrier dysfunction in ALI has been facilitated by study of the effects of statins in relevant cellular and animals models. Many of the pleotropic properties of these drugs, including direct effects on endothelial cell (EC) cytoskeletal rearrangement, NADPH oxidase, and nitric oxide activity, as well as effects on differential EC gene expression, are relevant to the pathobiology of ALI and suggest a potential therapeutic role for statins in this context. Moreover, results from preclinical studies and observations in relevant patient populations support the protective potential of statins in ALI, paving the way now for definitive clinical trials.</description><subject>Actins</subject><subject>acute lung injury</subject><subject>Acute respiratory distress syndrome</subject><subject>Adult respiratory distress syndrome</subject><subject>Animal models</subject><subject>Cholesterols</subject><subject>Dosage and administration</subject><subject>Drug therapy</subject><subject>Endothelium</subject><subject>Gene expression</subject><subject>Gene expression regulation</subject><subject>Genetic aspects</subject><subject>Inflammation</subject><subject>Lung injury</subject><subject>Lungs</subject><subject>Nitric oxide</subject><subject>Oxidases</subject><subject>Physiological aspects</subject><subject>pulmonary endothelium</subject><subject>Review</subject><subject>Review Article</subject><subject>Statins</subject><subject>Transcriptional regulatory elements</subject><issn>2045-8932</issn><issn>2045-8940</issn><issn>2045-8940</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>JFNAL</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqNkl2L1DAYhYMo7jLuvVdS8MabjvlsUxBhXdxdYUBB9zqkadLJ0Elq0q7Mvzel87Er4toUmqbneZNz3gLwGsElRZC8x5CynFcELxFkEPNn4Hy_ROHz45zgM3AR4wami1YIQ_4SnGFCSlxheg4-fB_kYF3MZLoz5-91lw1rHWSvx8GqLA5BDrrdZdZlUo2DzrrRteltM4bdK_DCyC7qi_1zAe6uP_-4us1XX2--XF2uclUginPVsKI2XFaEUtYog0hRqZKWyjScsRoXuMYoeVCNVJwqiRisodJMGiNxWUCyAB_nuv1Yb3WjtEun6kQf7FaGnfDSisdfnF2L1t8LwhibslqAd_sCwf8cdRzE1kalu0467ccoEOYpkBKmXBbg7R_SjR-DS_YEJpRAWBacn1St7LSwzvi0r5qKikuSPHNacpxUy7-o0mj01irvtLFp_REAZ0AFH2PQ5ugRQTEZEVNXxdRVMTc9IW8eZnMEDi1OgmoW_Eqb7Z4sKL7drfCnawiLYjoPntlRra2Sre-DjvFBIod_7AD3jTm5_k8oAfkMRNnqk-4flvf6TRx8eDqi31-n74U</recordid><startdate>201210</startdate><enddate>201210</enddate><creator>Singla, Sunit</creator><creator>Jacobsen, Jeffrey R.</creator><general>University of Chicago Press</general><general>SAGE Publications</general><general>Sage Publications Ltd. (UK)</general><general>John Wiley & Sons, Inc</general><general>Medknow Publications & Media Pvt Ltd</general><scope>JFNAL</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201210</creationdate><title>Statins as a novel therapeutic strategy in acute lung injury</title><author>Singla, Sunit ; Jacobsen, Jeffrey R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6142-cd56bf8a93445dcf1369c747cfd855b262b21105cdac84ca150b0ce5affa27603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Actins</topic><topic>acute lung injury</topic><topic>Acute respiratory distress syndrome</topic><topic>Adult respiratory distress syndrome</topic><topic>Animal models</topic><topic>Cholesterols</topic><topic>Dosage and administration</topic><topic>Drug therapy</topic><topic>Endothelium</topic><topic>Gene expression</topic><topic>Gene expression regulation</topic><topic>Genetic aspects</topic><topic>Inflammation</topic><topic>Lung injury</topic><topic>Lungs</topic><topic>Nitric oxide</topic><topic>Oxidases</topic><topic>Physiological aspects</topic><topic>pulmonary endothelium</topic><topic>Review</topic><topic>Review Article</topic><topic>Statins</topic><topic>Transcriptional regulatory elements</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Singla, Sunit</creatorcontrib><creatorcontrib>Jacobsen, Jeffrey R.</creatorcontrib><collection>Jstor Journals Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pulmonary Circulation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Singla, Sunit</au><au>Jacobsen, Jeffrey R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Statins as a novel therapeutic strategy in acute lung injury</atitle><jtitle>Pulmonary Circulation</jtitle><addtitle>Pulm Circ</addtitle><date>2012-10</date><risdate>2012</risdate><volume>2</volume><issue>4</issue><spage>397</spage><epage>406</epage><pages>397-406</pages><issn>2045-8932</issn><issn>2045-8940</issn><eissn>2045-8940</eissn><abstract>Acute lung injury (ALI) is a devastating clinical condition associated with pulmonary and systemic inflammation and characterized by incompetence of the pulmonary microvascular barrier culminating in noncardiogenic pulmonary edema. 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| subjects | Actins acute lung injury Acute respiratory distress syndrome Adult respiratory distress syndrome Animal models Cholesterols Dosage and administration Drug therapy Endothelium Gene expression Gene expression regulation Genetic aspects Inflammation Lung injury Lungs Nitric oxide Oxidases Physiological aspects pulmonary endothelium Review Review Article Statins Transcriptional regulatory elements |
| title | Statins as a novel therapeutic strategy in acute lung injury |
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