The novel oncogene CD24 and its arising role in the carcinogenesis of the GI tract: from research to therapy
CD24 was first described in the early 1980s and only attributed to scattered publications, referred to as a cell surface molecule in hematopoiesis. Recently, studies are accumulating to show that CD24 conveys a function in cell-to-cell interaction and regulation of proliferation and adhesion. CD24 a...
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| Veröffentlicht in: | Expert review of gastroenterology & hepatology 2008-02, Vol.2 (1), p.125-133 |
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| container_title | Expert review of gastroenterology & hepatology |
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| creator | Sagiv, Eyal Arber, Nadir |
| description | CD24 was first described in the early 1980s and only attributed to scattered publications, referred to as a cell surface molecule in hematopoiesis. Recently, studies are accumulating to show that CD24 conveys a function in cell-to-cell interaction and regulation of proliferation and adhesion. CD24 appears to be highly expressed in a large variety of human cancers and to contribute to the acceleration of tumor growth and metastases shedding by binding to platelet (P)-selectin, L1 and by evoking - to date unknown - intracellular signal pathways. Anti-CD24 monoclonal antibodies thus act as a promising cancer treatment as was shown in the setting of gastrointestinal cancers. Recent articles also correlate CD24 expression with the identification of 'tumor stem cells . |
| doi_str_mv | 10.1586/17474124.2.1.125 |
| format | Article |
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Recent articles also correlate CD24 expression with the identification of 'tumor stem cells .</description><subject>Animals</subject><subject>Anopheles</subject><subject>Antibodies, Monoclonal - therapeutic use</subject><subject>Cancer</subject><subject>cancer treatment</subject><subject>Care and treatment</subject><subject>CD24</subject><subject>CD24 Antigen - genetics</subject><subject>CD24 Antigen - immunology</subject><subject>CD24 Antigen - metabolism</subject><subject>Gastroenterology</subject><subject>Gastrointestinal Neoplasms - metabolism</subject><subject>Gastrointestinal Neoplasms - physiopathology</subject><subject>Gastrointestinal Neoplasms - therapy</subject><subject>Genetic aspects</subject><subject>GI cancer</subject><subject>Humans</subject><subject>Monoclonal antibodies</subject><subject>monoclonal antibody</subject><subject>oncogene</subject><subject>P-selectin</subject><subject>signal transduction</subject><subject>Stem cells</subject><subject>tumor stem cell</subject><subject>Tumors</subject><issn>1747-4124</issn><issn>1747-4132</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kUtvEzEUhUcIRB-wZ4UsVmwy-Dljl1UVSqlUiU1ZWx7PdeLKYwd7UpR_j9MEKpBAXtg6_s71vT5N84bglgjZfSA97zmhvKUtaQkVz5rTvbTghNHnv8-UnzRnpdxjLFQnxcvmhCjcU9aL0ybcrQHF9AABpWjTCiKg5SfKkYkj8nNBJvvi4wrlFAD5iObKW5Otj49w8QUl96he36A5GztfIJfThDIUqNwazWl_nc1m96p54Uwo8Pq4nzffPl_dLb8sbr9e3ywvbxeWEz4vOtZxriwfnBwVdhaMIlLxfmC25yMlmEvrmKMCOJfSGK56ix21ahDMKBjYefP-UHeT0_ctlFlPvlgIwURI26IJU0phKYSq6Lu_0Pu0zbF2p6WUlAtFuwq1B2hlAmgfXdoPWtcIk7cpgvNVv6SU1U_FDFcDPhhsTqVkcHqT_WTyThOs98npX8lpqomuyVXL22Mj22GC8clwjKoCHw_A_v08mR8ph1HPZhdSdtlE64tm_yl_8Yd7DSbM6xokPA38T_NPjTG3wA</recordid><startdate>20080201</startdate><enddate>20080201</enddate><creator>Sagiv, Eyal</creator><creator>Arber, Nadir</creator><general>Informa Healthcare</general><general>Taylor & Francis</general><general>Expert Reviews Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7TO</scope><scope>H94</scope></search><sort><creationdate>20080201</creationdate><title>The novel oncogene CD24 and its arising role in the carcinogenesis of the GI tract: from research to therapy</title><author>Sagiv, Eyal ; Arber, Nadir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-636449c4bf8d90fcea918947b3c74d21048cf3f25e4488aa497c0f2c9b53a9eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Anopheles</topic><topic>Antibodies, Monoclonal - therapeutic use</topic><topic>Cancer</topic><topic>cancer treatment</topic><topic>Care and treatment</topic><topic>CD24</topic><topic>CD24 Antigen - genetics</topic><topic>CD24 Antigen - immunology</topic><topic>CD24 Antigen - metabolism</topic><topic>Gastroenterology</topic><topic>Gastrointestinal Neoplasms - metabolism</topic><topic>Gastrointestinal Neoplasms - physiopathology</topic><topic>Gastrointestinal Neoplasms - therapy</topic><topic>Genetic aspects</topic><topic>GI cancer</topic><topic>Humans</topic><topic>Monoclonal antibodies</topic><topic>monoclonal antibody</topic><topic>oncogene</topic><topic>P-selectin</topic><topic>signal transduction</topic><topic>Stem cells</topic><topic>tumor stem cell</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sagiv, Eyal</creatorcontrib><creatorcontrib>Arber, Nadir</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Expert review of gastroenterology & hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sagiv, Eyal</au><au>Arber, Nadir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The novel oncogene CD24 and its arising role in the carcinogenesis of the GI tract: from research to therapy</atitle><jtitle>Expert review of gastroenterology & hepatology</jtitle><addtitle>Expert Rev Gastroenterol Hepatol</addtitle><date>2008-02-01</date><risdate>2008</risdate><volume>2</volume><issue>1</issue><spage>125</spage><epage>133</epage><pages>125-133</pages><issn>1747-4124</issn><eissn>1747-4132</eissn><abstract>CD24 was first described in the early 1980s and only attributed to scattered publications, referred to as a cell surface molecule in hematopoiesis. 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| identifier | ISSN: 1747-4124 |
| ispartof | Expert review of gastroenterology & hepatology, 2008-02, Vol.2 (1), p.125-133 |
| issn | 1747-4124 1747-4132 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Anopheles Antibodies, Monoclonal - therapeutic use Cancer cancer treatment Care and treatment CD24 CD24 Antigen - genetics CD24 Antigen - immunology CD24 Antigen - metabolism Gastroenterology Gastrointestinal Neoplasms - metabolism Gastrointestinal Neoplasms - physiopathology Gastrointestinal Neoplasms - therapy Genetic aspects GI cancer Humans Monoclonal antibodies monoclonal antibody oncogene P-selectin signal transduction Stem cells tumor stem cell Tumors |
| title | The novel oncogene CD24 and its arising role in the carcinogenesis of the GI tract: from research to therapy |
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