Factors Predictive of Use and of Benefit From Continuous Glucose Monitoring in Type 1 Diabetes
Factors Predictive of Use and of Benefit From Continuous Glucose Monitoring in Type 1 Diabetes Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group * Corresponding author: Roy W. Beck, jdrfapp{at}jaeb.org . Abstract OBJECTIVE To evaluate factors associated with successful...
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| creator | Beck, Roy W Buckingham, Bruce Miller, Kellee Wolpert, Howard Xing, Dongyuan Block, Jennifer M Chase, H Peter Hirsch, Irl Kollman, Craig Laffel, Lori Lawrence, Jean M Milaszewski, Kerry Ruedy, Katrina J Tamborlane, William V |
| description | Factors Predictive of Use and of Benefit From Continuous Glucose Monitoring in Type 1 Diabetes
Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group *
Corresponding author: Roy W. Beck, jdrfapp{at}jaeb.org .
Abstract
OBJECTIVE To evaluate factors associated with successful use of continuous glucose monitoring (CGM) among participants with intensively
treated type 1 diabetes in the Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Randomized Clinical Trial.
RESEARCH DESIGN AND METHODS The 232 participants randomly assigned to the CGM group (165 with baseline A1C ≥7.0% and 67 with A1C |
| doi_str_mv | 10.2337/dc09-0889 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_gale_infotracacademiconefile_A212406998</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A212406998</galeid><sourcerecordid>A212406998</sourcerecordid><originalsourceid>FETCH-LOGICAL-c638t-ea2c5d35d608c90d5a0e767b0dd6ea5c7e3f2663285d943dede7421b198408ba3</originalsourceid><addsrcrecordid>eNptkl9rFDEUxQdR7Fp98AvIoIgUmZr_k7wIde1WoaIP7ashm9zZTZlN1mSm0m9vhl2qlSUPCTe_e5J7OFX1EqNTQmn7wVmkGiSlelTNsKK84ZzJx9UMYaYarhQ5qp7lfIMQYkzKp9URVqLlBIlZ9XNh7BBTrn8kcN4O_hbq2NXXGWoT3HT8BAE6P9SLFDf1PIbBhzGOub7oRxsL9i0GXxR8WNU-1Fd3W6hx_dmbJQyQn1dPOtNneLHfj6vrxfnV_Etz-f3i6_zssrGCyqEBQyx3lDuBpFXIcYOgFe0SOSfAcNsC7YgQlEjuFKMOHLSM4CVWkiG5NPS4-rjT3Y7LDTgLYUim19vkNybd6Wi8fngT_Fqv4q0mrZDFjSLwbi-Q4q8R8qA3PlvoexOgTKtbyjBmWNJCvv6PvIljCmU6TQhFlArVFujNDlqZHrQPXSyv2klSnxFMGBJKyUI1B6hVMbx8MU62l_ID_vQAX5aDjbcHG052DTbFnBN0945gpKfo6Ck6eopOYV_9a-Ffcp-VArzdAyZb03fJBOvzPUcIxlxgVrj3O27tV-vfPoF2-zRMB2tKgRKNcVFmLf0DeD_YRw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>223033697</pqid></control><display><type>article</type><title>Factors Predictive of Use and of Benefit From Continuous Glucose Monitoring in Type 1 Diabetes</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Beck, Roy W ; Buckingham, Bruce ; Miller, Kellee ; Wolpert, Howard ; Xing, Dongyuan ; Block, Jennifer M ; Chase, H Peter ; Hirsch, Irl ; Kollman, Craig ; Laffel, Lori ; Lawrence, Jean M ; Milaszewski, Kerry ; Ruedy, Katrina J ; Tamborlane, William V</creator><creatorcontrib>Beck, Roy W ; Buckingham, Bruce ; Miller, Kellee ; Wolpert, Howard ; Xing, Dongyuan ; Block, Jennifer M ; Chase, H Peter ; Hirsch, Irl ; Kollman, Craig ; Laffel, Lori ; Lawrence, Jean M ; Milaszewski, Kerry ; Ruedy, Katrina J ; Tamborlane, William V ; Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group</creatorcontrib><description>Factors Predictive of Use and of Benefit From Continuous Glucose Monitoring in Type 1 Diabetes
Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group *
Corresponding author: Roy W. Beck, jdrfapp{at}jaeb.org .
Abstract
OBJECTIVE To evaluate factors associated with successful use of continuous glucose monitoring (CGM) among participants with intensively
treated type 1 diabetes in the Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Randomized Clinical Trial.
RESEARCH DESIGN AND METHODS The 232 participants randomly assigned to the CGM group (165 with baseline A1C ≥7.0% and 67 with A1C <7.0%) were asked to
use CGM on a daily basis. The associations of baseline factors and early CGM use with CGM use ≥6 days/week in the 6th month
and with change in A1C from baseline to 6 months were evaluated in regression models.
RESULTS The only baseline factors found to be associated with greater CGM use in month 6 were age ≥25 years ( P < 0.001) and more frequent self-reported prestudy blood glucose meter measurements per day ( P < 0.001). CGM use and the percentage of CGM glucose values between 71 and 180 mg/dl during the 1st month were predictive
of CGM use in month 6 ( P < 0.001 and P = 0.002, respectively). More frequent CGM use was associated with a greater reduction in A1C from baseline to 6 months ( P < 0.001), a finding present in all age-groups.
CONCLUSIONS After 6 months, near-daily CGM use is more frequent in intensively treated adults with type 1 diabetes than in children and
adolescents, although in all age-groups near-daily CGM use is associated with a similar reduction in A1C. Frequency of blood
glucose meter monitoring and initial CGM use may help predict the likelihood of long-term CGM benefit in intensively treated
patients with type 1 diabetes of all ages.
Footnotes
↵ *The list of members of the Writing Committee can be found in the appendix , and a complete list of the members of the Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group
is available in an online appendix at http://care.diabetesjournals.org/cgi/content/full/dc09-0889/DC1 .
Clinical trial reg. no. NCT00406133, clinicaltrials.gov .
The study was designed and conducted by the investigators who collectively wrote the manuscript and vouch for the data. The
investigators had complete autonomy to analyze and report the trial results. There were no agreements concerning confidentiality
of the data between the Juvenile Diabetes Research Foundation and the authors or their institutions. The Jaeb Center for Health
Research had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy
of the data analysis.
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore
be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
Received May 14, 2009.
Accepted July 21, 2009.
© 2009 by the American Diabetes Association.</description><identifier>ISSN: 0149-5992</identifier><identifier>EISSN: 1935-5548</identifier><identifier>DOI: 10.2337/dc09-0889</identifier><identifier>PMID: 19675206</identifier><identifier>CODEN: DICAD2</identifier><language>eng</language><publisher>Alexandria, VA: American Diabetes Association</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Blood Glucose - analysis ; Care and treatment ; Child ; Diabetes ; Diabetes Mellitus, Type 1 - blood ; Diabetes Mellitus, Type 1 - drug therapy ; Diabetes. Impaired glucose tolerance ; Diagnosis ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Fees & charges ; Follow-Up Studies ; Glucose monitors ; Glycated Hemoglobin A - analysis ; Health aspects ; Humans ; Hypoglycemic Agents - therapeutic use ; Insulin - therapeutic use ; Insulin Infusion Systems ; Medical sciences ; Metabolic diseases ; Middle Aged ; Miscellaneous ; Monitoring systems ; Monitoring, Ambulatory - methods ; Original Research ; Patient Selection ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Statistical methods ; Studies ; Type 1 diabetes</subject><ispartof>Diabetes care, 2009-11, Vol.32 (11), p.1947-1953</ispartof><rights>2009 INIST-CNRS</rights><rights>COPYRIGHT 2009 American Diabetes Association</rights><rights>Copyright American Diabetes Association Nov 2009</rights><rights>2009 by the American Diabetes Association. 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c638t-ea2c5d35d608c90d5a0e767b0dd6ea5c7e3f2663285d943dede7421b198408ba3</citedby><cites>FETCH-LOGICAL-c638t-ea2c5d35d608c90d5a0e767b0dd6ea5c7e3f2663285d943dede7421b198408ba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22115614$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19675206$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Beck, Roy W</creatorcontrib><creatorcontrib>Buckingham, Bruce</creatorcontrib><creatorcontrib>Miller, Kellee</creatorcontrib><creatorcontrib>Wolpert, Howard</creatorcontrib><creatorcontrib>Xing, Dongyuan</creatorcontrib><creatorcontrib>Block, Jennifer M</creatorcontrib><creatorcontrib>Chase, H Peter</creatorcontrib><creatorcontrib>Hirsch, Irl</creatorcontrib><creatorcontrib>Kollman, Craig</creatorcontrib><creatorcontrib>Laffel, Lori</creatorcontrib><creatorcontrib>Lawrence, Jean M</creatorcontrib><creatorcontrib>Milaszewski, Kerry</creatorcontrib><creatorcontrib>Ruedy, Katrina J</creatorcontrib><creatorcontrib>Tamborlane, William V</creatorcontrib><creatorcontrib>Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group</creatorcontrib><title>Factors Predictive of Use and of Benefit From Continuous Glucose Monitoring in Type 1 Diabetes</title><title>Diabetes care</title><addtitle>Diabetes Care</addtitle><description>Factors Predictive of Use and of Benefit From Continuous Glucose Monitoring in Type 1 Diabetes
Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group *
Corresponding author: Roy W. Beck, jdrfapp{at}jaeb.org .
Abstract
OBJECTIVE To evaluate factors associated with successful use of continuous glucose monitoring (CGM) among participants with intensively
treated type 1 diabetes in the Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Randomized Clinical Trial.
RESEARCH DESIGN AND METHODS The 232 participants randomly assigned to the CGM group (165 with baseline A1C ≥7.0% and 67 with A1C <7.0%) were asked to
use CGM on a daily basis. The associations of baseline factors and early CGM use with CGM use ≥6 days/week in the 6th month
and with change in A1C from baseline to 6 months were evaluated in regression models.
RESULTS The only baseline factors found to be associated with greater CGM use in month 6 were age ≥25 years ( P < 0.001) and more frequent self-reported prestudy blood glucose meter measurements per day ( P < 0.001). CGM use and the percentage of CGM glucose values between 71 and 180 mg/dl during the 1st month were predictive
of CGM use in month 6 ( P < 0.001 and P = 0.002, respectively). More frequent CGM use was associated with a greater reduction in A1C from baseline to 6 months ( P < 0.001), a finding present in all age-groups.
CONCLUSIONS After 6 months, near-daily CGM use is more frequent in intensively treated adults with type 1 diabetes than in children and
adolescents, although in all age-groups near-daily CGM use is associated with a similar reduction in A1C. Frequency of blood
glucose meter monitoring and initial CGM use may help predict the likelihood of long-term CGM benefit in intensively treated
patients with type 1 diabetes of all ages.
Footnotes
↵ *The list of members of the Writing Committee can be found in the appendix , and a complete list of the members of the Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group
is available in an online appendix at http://care.diabetesjournals.org/cgi/content/full/dc09-0889/DC1 .
Clinical trial reg. no. NCT00406133, clinicaltrials.gov .
The study was designed and conducted by the investigators who collectively wrote the manuscript and vouch for the data. The
investigators had complete autonomy to analyze and report the trial results. There were no agreements concerning confidentiality
of the data between the Juvenile Diabetes Research Foundation and the authors or their institutions. The Jaeb Center for Health
Research had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy
of the data analysis.
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore
be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
Received May 14, 2009.
Accepted July 21, 2009.
© 2009 by the American Diabetes Association.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - analysis</subject><subject>Care and treatment</subject><subject>Child</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 1 - blood</subject><subject>Diabetes Mellitus, Type 1 - drug therapy</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diagnosis</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Fees & charges</subject><subject>Follow-Up Studies</subject><subject>Glucose monitors</subject><subject>Glycated Hemoglobin A - analysis</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Insulin - therapeutic use</subject><subject>Insulin Infusion Systems</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Monitoring systems</subject><subject>Monitoring, Ambulatory - methods</subject><subject>Original Research</subject><subject>Patient Selection</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Statistical methods</subject><subject>Studies</subject><subject>Type 1 diabetes</subject><issn>0149-5992</issn><issn>1935-5548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkl9rFDEUxQdR7Fp98AvIoIgUmZr_k7wIde1WoaIP7ashm9zZTZlN1mSm0m9vhl2qlSUPCTe_e5J7OFX1EqNTQmn7wVmkGiSlelTNsKK84ZzJx9UMYaYarhQ5qp7lfIMQYkzKp9URVqLlBIlZ9XNh7BBTrn8kcN4O_hbq2NXXGWoT3HT8BAE6P9SLFDf1PIbBhzGOub7oRxsL9i0GXxR8WNU-1Fd3W6hx_dmbJQyQn1dPOtNneLHfj6vrxfnV_Etz-f3i6_zssrGCyqEBQyx3lDuBpFXIcYOgFe0SOSfAcNsC7YgQlEjuFKMOHLSM4CVWkiG5NPS4-rjT3Y7LDTgLYUim19vkNybd6Wi8fngT_Fqv4q0mrZDFjSLwbi-Q4q8R8qA3PlvoexOgTKtbyjBmWNJCvv6PvIljCmU6TQhFlArVFujNDlqZHrQPXSyv2klSnxFMGBJKyUI1B6hVMbx8MU62l_ID_vQAX5aDjbcHG052DTbFnBN0945gpKfo6Ck6eopOYV_9a-Ffcp-VArzdAyZb03fJBOvzPUcIxlxgVrj3O27tV-vfPoF2-zRMB2tKgRKNcVFmLf0DeD_YRw</recordid><startdate>20091101</startdate><enddate>20091101</enddate><creator>Beck, Roy W</creator><creator>Buckingham, Bruce</creator><creator>Miller, Kellee</creator><creator>Wolpert, Howard</creator><creator>Xing, Dongyuan</creator><creator>Block, Jennifer M</creator><creator>Chase, H Peter</creator><creator>Hirsch, Irl</creator><creator>Kollman, Craig</creator><creator>Laffel, Lori</creator><creator>Lawrence, Jean M</creator><creator>Milaszewski, Kerry</creator><creator>Ruedy, Katrina J</creator><creator>Tamborlane, William V</creator><general>American Diabetes Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20091101</creationdate><title>Factors Predictive of Use and of Benefit From Continuous Glucose Monitoring in Type 1 Diabetes</title><author>Beck, Roy W ; Buckingham, Bruce ; Miller, Kellee ; Wolpert, Howard ; Xing, Dongyuan ; Block, Jennifer M ; Chase, H Peter ; Hirsch, Irl ; Kollman, Craig ; Laffel, Lori ; Lawrence, Jean M ; Milaszewski, Kerry ; Ruedy, Katrina J ; Tamborlane, William V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c638t-ea2c5d35d608c90d5a0e767b0dd6ea5c7e3f2663285d943dede7421b198408ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - analysis</topic><topic>Care and treatment</topic><topic>Child</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 1 - blood</topic><topic>Diabetes Mellitus, Type 1 - drug therapy</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diagnosis</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Fees & charges</topic><topic>Follow-Up Studies</topic><topic>Glucose monitors</topic><topic>Glycated Hemoglobin A - analysis</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>Insulin - therapeutic use</topic><topic>Insulin Infusion Systems</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Monitoring systems</topic><topic>Monitoring, Ambulatory - methods</topic><topic>Original Research</topic><topic>Patient Selection</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Statistical methods</topic><topic>Studies</topic><topic>Type 1 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Beck, Roy W</creatorcontrib><creatorcontrib>Buckingham, Bruce</creatorcontrib><creatorcontrib>Miller, Kellee</creatorcontrib><creatorcontrib>Wolpert, Howard</creatorcontrib><creatorcontrib>Xing, Dongyuan</creatorcontrib><creatorcontrib>Block, Jennifer M</creatorcontrib><creatorcontrib>Chase, H Peter</creatorcontrib><creatorcontrib>Hirsch, Irl</creatorcontrib><creatorcontrib>Kollman, Craig</creatorcontrib><creatorcontrib>Laffel, Lori</creatorcontrib><creatorcontrib>Lawrence, Jean M</creatorcontrib><creatorcontrib>Milaszewski, Kerry</creatorcontrib><creatorcontrib>Ruedy, Katrina J</creatorcontrib><creatorcontrib>Tamborlane, William V</creatorcontrib><creatorcontrib>Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Diabetes care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Beck, Roy W</au><au>Buckingham, Bruce</au><au>Miller, Kellee</au><au>Wolpert, Howard</au><au>Xing, Dongyuan</au><au>Block, Jennifer M</au><au>Chase, H Peter</au><au>Hirsch, Irl</au><au>Kollman, Craig</au><au>Laffel, Lori</au><au>Lawrence, Jean M</au><au>Milaszewski, Kerry</au><au>Ruedy, Katrina J</au><au>Tamborlane, William V</au><aucorp>Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors Predictive of Use and of Benefit From Continuous Glucose Monitoring in Type 1 Diabetes</atitle><jtitle>Diabetes care</jtitle><addtitle>Diabetes Care</addtitle><date>2009-11-01</date><risdate>2009</risdate><volume>32</volume><issue>11</issue><spage>1947</spage><epage>1953</epage><pages>1947-1953</pages><issn>0149-5992</issn><eissn>1935-5548</eissn><coden>DICAD2</coden><abstract>Factors Predictive of Use and of Benefit From Continuous Glucose Monitoring in Type 1 Diabetes
Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group *
Corresponding author: Roy W. Beck, jdrfapp{at}jaeb.org .
Abstract
OBJECTIVE To evaluate factors associated with successful use of continuous glucose monitoring (CGM) among participants with intensively
treated type 1 diabetes in the Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Randomized Clinical Trial.
RESEARCH DESIGN AND METHODS The 232 participants randomly assigned to the CGM group (165 with baseline A1C ≥7.0% and 67 with A1C <7.0%) were asked to
use CGM on a daily basis. The associations of baseline factors and early CGM use with CGM use ≥6 days/week in the 6th month
and with change in A1C from baseline to 6 months were evaluated in regression models.
RESULTS The only baseline factors found to be associated with greater CGM use in month 6 were age ≥25 years ( P < 0.001) and more frequent self-reported prestudy blood glucose meter measurements per day ( P < 0.001). CGM use and the percentage of CGM glucose values between 71 and 180 mg/dl during the 1st month were predictive
of CGM use in month 6 ( P < 0.001 and P = 0.002, respectively). More frequent CGM use was associated with a greater reduction in A1C from baseline to 6 months ( P < 0.001), a finding present in all age-groups.
CONCLUSIONS After 6 months, near-daily CGM use is more frequent in intensively treated adults with type 1 diabetes than in children and
adolescents, although in all age-groups near-daily CGM use is associated with a similar reduction in A1C. Frequency of blood
glucose meter monitoring and initial CGM use may help predict the likelihood of long-term CGM benefit in intensively treated
patients with type 1 diabetes of all ages.
Footnotes
↵ *The list of members of the Writing Committee can be found in the appendix , and a complete list of the members of the Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group
is available in an online appendix at http://care.diabetesjournals.org/cgi/content/full/dc09-0889/DC1 .
Clinical trial reg. no. NCT00406133, clinicaltrials.gov .
The study was designed and conducted by the investigators who collectively wrote the manuscript and vouch for the data. The
investigators had complete autonomy to analyze and report the trial results. There were no agreements concerning confidentiality
of the data between the Juvenile Diabetes Research Foundation and the authors or their institutions. The Jaeb Center for Health
Research had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy
of the data analysis.
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore
be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
Received May 14, 2009.
Accepted July 21, 2009.
© 2009 by the American Diabetes Association.</abstract><cop>Alexandria, VA</cop><pub>American Diabetes Association</pub><pmid>19675206</pmid><doi>10.2337/dc09-0889</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0149-5992 |
| ispartof | Diabetes care, 2009-11, Vol.32 (11), p.1947-1953 |
| issn | 0149-5992 1935-5548 |
| language | eng |
| recordid | cdi_gale_infotracacademiconefile_A212406998 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adolescent Adult Aged Biological and medical sciences Blood Glucose - analysis Care and treatment Child Diabetes Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - drug therapy Diabetes. Impaired glucose tolerance Diagnosis Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fees & charges Follow-Up Studies Glucose monitors Glycated Hemoglobin A - analysis Health aspects Humans Hypoglycemic Agents - therapeutic use Insulin - therapeutic use Insulin Infusion Systems Medical sciences Metabolic diseases Middle Aged Miscellaneous Monitoring systems Monitoring, Ambulatory - methods Original Research Patient Selection Public health. Hygiene Public health. Hygiene-occupational medicine Statistical methods Studies Type 1 diabetes |
| title | Factors Predictive of Use and of Benefit From Continuous Glucose Monitoring in Type 1 Diabetes |
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