Predictors for Nonsentinel Node Involvement in Breast Cancer Patients with Micrometastases in the Sentinel Lymph Node
Sentinel lymph node (SLN) biopsy in breast cancer allows for a more thorough pathologic assessment with serial sectioning and cytokeratin staining. This has resulted in increased detection of micrometastatic disease (tumor size
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| Veröffentlicht in: | Proceedings - Baylor University. Medical Center 2003-01, Vol.16 (1), p.3-6 |
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| creator | Ganaraj, Archana Kuhn, Joseph A. Jones, Ronald C. Grant, Michael D. Andrews, Valerie R. Knox, Sally M. Netto, Georges J. Altrabulsi, Basel Livingston, Sheryl A. Mccarty, Todd M. |
| description | Sentinel lymph node (SLN) biopsy in breast cancer allows for a more thorough pathologic assessment with serial sectioning and cytokeratin staining. This has resulted in increased detection of micrometastatic disease (tumor size |
| doi_str_mv | 10.1080/08998280.2003.11927881 |
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1
a and T
1
b (n = 5), T
1
c (n = 15), and T2 (n = 4). A total of 328 nonsentinel lymph nodes were examined, including 225 from patients with infiltrating ductal carcinoma (n = 17) and 103 from patients with infiltrating lobular carcinoma (n = 7). In the patients with infiltrating ductal carcinoma, no additional nodal metastases were identified, while in those with infiltrating lobular carcinoma, additional nodal disease was found in 5 lymph nodes (2 of 12 patients, 17%). Primary tumor characteristics were not predictive of additional nodal disease. These data suggest that patients with micrometastasis in the SLN from infiltrating lobular carcinoma have a significant risk of harboring additional nodal disease and should undergo completion axillary dissection. However, those with micrometastatic disease from infiltrating ductal carcinoma have a very low incidence of additional metastasis and may not need completion axillary dissection.</description><identifier>ISSN: 0899-8280</identifier><identifier>EISSN: 1525-3252</identifier><identifier>DOI: 10.1080/08998280.2003.11927881</identifier><identifier>PMID: 16278715</identifier><language>eng</language><publisher>United States: Taylor & Francis</publisher><subject>Biopsy ; Breast cancer ; Health aspects ; Lymph nodes ; Lymphatic metastasis ; Prognosis ; Risk factors ; Women</subject><ispartof>Proceedings - Baylor University. Medical Center, 2003-01, Vol.16 (1), p.3-6</ispartof><rights>Copyright Taylor & Francis</rights><rights>COPYRIGHT 2003 Taylor & Francis Group LLC</rights><rights>Copyright Baylor University Medical Center Jan 2003</rights><rights>Copyright © 2003, Baylor University Medical Center 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4101-a766421f879ee16afe23967da62095c95115fb2726318127791a55afe20482283</citedby><cites>FETCH-LOGICAL-c4101-a766421f879ee16afe23967da62095c95115fb2726318127791a55afe20482283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1200802/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1200802/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16278715$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ganaraj, Archana</creatorcontrib><creatorcontrib>Kuhn, Joseph A.</creatorcontrib><creatorcontrib>Jones, Ronald C.</creatorcontrib><creatorcontrib>Grant, Michael D.</creatorcontrib><creatorcontrib>Andrews, Valerie R.</creatorcontrib><creatorcontrib>Knox, Sally M.</creatorcontrib><creatorcontrib>Netto, Georges J.</creatorcontrib><creatorcontrib>Altrabulsi, Basel</creatorcontrib><creatorcontrib>Livingston, Sheryl A.</creatorcontrib><creatorcontrib>Mccarty, Todd M.</creatorcontrib><title>Predictors for Nonsentinel Node Involvement in Breast Cancer Patients with Micrometastases in the Sentinel Lymph Node</title><title>Proceedings - Baylor University. Medical Center</title><addtitle>Proc (Bayl Univ Med Cent)</addtitle><description>Sentinel lymph node (SLN) biopsy in breast cancer allows for a more thorough pathologic assessment with serial sectioning and cytokeratin staining. This has resulted in increased detection of micrometastatic disease (tumor size <2 mm) in the SLN. Unfortunately, the value of completion axillary dissection after finding micrometastatic disease in the SLN remains poorly defined. Over a 2-year period, a prospective database of 305 patients who underwent SLN biopsy for breast cancer at Baylor University Medical Center was reviewed. Eighty-four (27.5%) of the patients had evidence of metastatic disease in the SLN. Twenty-four of the 41 patients identified as having micrometastatic disease in the SLN underwent completion axillary lymph node dissection. In these patients, all nonsentinel nodes were further studied by serial sectioning and immunohistochemistry. The median age of these 24 patients was 52 years (range, 34-83). Their primary tumor stages were T
1
a and T
1
b (n = 5), T
1
c (n = 15), and T2 (n = 4). A total of 328 nonsentinel lymph nodes were examined, including 225 from patients with infiltrating ductal carcinoma (n = 17) and 103 from patients with infiltrating lobular carcinoma (n = 7). In the patients with infiltrating ductal carcinoma, no additional nodal metastases were identified, while in those with infiltrating lobular carcinoma, additional nodal disease was found in 5 lymph nodes (2 of 12 patients, 17%). Primary tumor characteristics were not predictive of additional nodal disease. These data suggest that patients with micrometastasis in the SLN from infiltrating lobular carcinoma have a significant risk of harboring additional nodal disease and should undergo completion axillary dissection. However, those with micrometastatic disease from infiltrating ductal carcinoma have a very low incidence of additional metastasis and may not need completion axillary dissection.</description><subject>Biopsy</subject><subject>Breast cancer</subject><subject>Health aspects</subject><subject>Lymph nodes</subject><subject>Lymphatic metastasis</subject><subject>Prognosis</subject><subject>Risk factors</subject><subject>Women</subject><issn>0899-8280</issn><issn>1525-3252</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNqFkl2LEzEUhgdR3Lr6F5aA4N3UnGTyMTdCLX4sVF1Qr0N25sw2y0xSk2mX_nsztnVdESQXCSfPec8Hb1FcAJ0D1fQ11XWtmaZzRimfA9RMaQ2PihkIJkrOBHtczCaonKiz4llKt5RWwEE9Lc5AZlyBmBXbq4ita8YQE-lCJJ-DT-hH57HP7xbJpd-FfodDDhLnyduINo1kaX2DkVzZ0eWPRO7cuCafXBPDgGMGbMI04eMaydeT3mo_bNa_VJ8XTzrbJ3xxvM-L7-_ffVt-LFdfPlwuF6uyqYBCaZWUFYNOqxoRpO2Q8Vqq1kpGa9HUAkB010wxyUEDU6oGK8SE0Uozpvl58eagu9leD9g2uZNoe7OJbrBxb4J15uGPd2tzE3YG8lo1ZVng1VEghh9bTKMZXGqw763HsE1GgaSyoiKDL_8Cb8M2-jycAcqZhporek_d2B6N813IVZtJ0ixAAtOVlDxT839Q-bQ4uCZ47FyOP0iQh4S8_5Qidr8nBGomu5iTXcxkF3OyS068-HM_92lHf2RgcQCmLuJg70LsWzPafR9iF7MJXDL8P0V-Ap0xzdg</recordid><startdate>20030101</startdate><enddate>20030101</enddate><creator>Ganaraj, Archana</creator><creator>Kuhn, Joseph A.</creator><creator>Jones, Ronald C.</creator><creator>Grant, Michael D.</creator><creator>Andrews, Valerie R.</creator><creator>Knox, Sally M.</creator><creator>Netto, Georges J.</creator><creator>Altrabulsi, Basel</creator><creator>Livingston, Sheryl A.</creator><creator>Mccarty, Todd M.</creator><general>Taylor & Francis</general><general>Taylor & Francis Group LLC</general><general>Taylor & Francis Ltd</general><general>Baylor Health Care System</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20030101</creationdate><title>Predictors for Nonsentinel Node Involvement in Breast Cancer Patients with Micrometastases in the Sentinel Lymph Node</title><author>Ganaraj, Archana ; Kuhn, Joseph A. ; Jones, Ronald C. ; Grant, Michael D. ; Andrews, Valerie R. ; Knox, Sally M. ; Netto, Georges J. ; Altrabulsi, Basel ; Livingston, Sheryl A. ; Mccarty, Todd M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4101-a766421f879ee16afe23967da62095c95115fb2726318127791a55afe20482283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Biopsy</topic><topic>Breast cancer</topic><topic>Health aspects</topic><topic>Lymph nodes</topic><topic>Lymphatic metastasis</topic><topic>Prognosis</topic><topic>Risk factors</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ganaraj, Archana</creatorcontrib><creatorcontrib>Kuhn, Joseph A.</creatorcontrib><creatorcontrib>Jones, Ronald C.</creatorcontrib><creatorcontrib>Grant, Michael D.</creatorcontrib><creatorcontrib>Andrews, Valerie R.</creatorcontrib><creatorcontrib>Knox, Sally M.</creatorcontrib><creatorcontrib>Netto, Georges J.</creatorcontrib><creatorcontrib>Altrabulsi, Basel</creatorcontrib><creatorcontrib>Livingston, Sheryl A.</creatorcontrib><creatorcontrib>Mccarty, Todd M.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings - Baylor University. Medical Center</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ganaraj, Archana</au><au>Kuhn, Joseph A.</au><au>Jones, Ronald C.</au><au>Grant, Michael D.</au><au>Andrews, Valerie R.</au><au>Knox, Sally M.</au><au>Netto, Georges J.</au><au>Altrabulsi, Basel</au><au>Livingston, Sheryl A.</au><au>Mccarty, Todd M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictors for Nonsentinel Node Involvement in Breast Cancer Patients with Micrometastases in the Sentinel Lymph Node</atitle><jtitle>Proceedings - Baylor University. Medical Center</jtitle><addtitle>Proc (Bayl Univ Med Cent)</addtitle><date>2003-01-01</date><risdate>2003</risdate><volume>16</volume><issue>1</issue><spage>3</spage><epage>6</epage><pages>3-6</pages><issn>0899-8280</issn><eissn>1525-3252</eissn><abstract>Sentinel lymph node (SLN) biopsy in breast cancer allows for a more thorough pathologic assessment with serial sectioning and cytokeratin staining. This has resulted in increased detection of micrometastatic disease (tumor size <2 mm) in the SLN. Unfortunately, the value of completion axillary dissection after finding micrometastatic disease in the SLN remains poorly defined. Over a 2-year period, a prospective database of 305 patients who underwent SLN biopsy for breast cancer at Baylor University Medical Center was reviewed. Eighty-four (27.5%) of the patients had evidence of metastatic disease in the SLN. Twenty-four of the 41 patients identified as having micrometastatic disease in the SLN underwent completion axillary lymph node dissection. In these patients, all nonsentinel nodes were further studied by serial sectioning and immunohistochemistry. The median age of these 24 patients was 52 years (range, 34-83). Their primary tumor stages were T
1
a and T
1
b (n = 5), T
1
c (n = 15), and T2 (n = 4). A total of 328 nonsentinel lymph nodes were examined, including 225 from patients with infiltrating ductal carcinoma (n = 17) and 103 from patients with infiltrating lobular carcinoma (n = 7). In the patients with infiltrating ductal carcinoma, no additional nodal metastases were identified, while in those with infiltrating lobular carcinoma, additional nodal disease was found in 5 lymph nodes (2 of 12 patients, 17%). Primary tumor characteristics were not predictive of additional nodal disease. These data suggest that patients with micrometastasis in the SLN from infiltrating lobular carcinoma have a significant risk of harboring additional nodal disease and should undergo completion axillary dissection. However, those with micrometastatic disease from infiltrating ductal carcinoma have a very low incidence of additional metastasis and may not need completion axillary dissection.</abstract><cop>United States</cop><pub>Taylor & Francis</pub><pmid>16278715</pmid><doi>10.1080/08998280.2003.11927881</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Biopsy Breast cancer Health aspects Lymph nodes Lymphatic metastasis Prognosis Risk factors Women |
| title | Predictors for Nonsentinel Node Involvement in Breast Cancer Patients with Micrometastases in the Sentinel Lymph Node |
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