Multiple Drug Resistance in Cancer Revisited: The Cancer Stem Cell Hypothesis

The failure to eradicate cancer may be as fundamental as a misidentification of the target. Current therapies succeed at eliminating bulky disease but often miss a tumor reservoir that is the source of disease recurrence and metastasis. Recent advances in the understanding of tissue development and...

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Veröffentlicht in:	Journal of clinical pharmacology 2005-08, Vol.45 (8), p.872-877
Hauptverfasser:	Donnenberg, Vera S., Donnenberg, Albert D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology ATP Binding Cassette Transporter, Subfamily B - antagonists & inhibitors ATP Binding Cassette Transporter, Subfamily B - metabolism ATP Binding Cassette Transporter, Subfamily B, Member 1 - antagonists & inhibitors ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism ATP Binding Cassette Transporter, Subfamily G, Member 2 ATP-Binding Cassette Sub-Family B Member 4 ATP-Binding Cassette Transporters - antagonists & inhibitors ATP-Binding Cassette Transporters - metabolism Cancer Cancer cells Cancer stem cell Chemotherapy Drug resistance Drug Resistance, Multiple Drug Resistance, Neoplasm Health aspects Humans multiple drug resistance Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - metabolism Neoplasms - drug therapy Neoplasms - pathology Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism oncogenesis Risk factors
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