Researching COVID to enhance recovery
Importance RECOVER-Pathology is a cross-sectional study of decedents dying at least 15 days following initial SARS-CoV-2 infection. Eligible decedents must meet WHO criteria for suspected, probable, or confirmed infection and must be aged 18 years or more at the time of death. Enrollment occurs at 7...
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| Veröffentlicht in: | PloS one 2024-01, Vol.19 (1), p.e0285645 |
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| creator | Troxel, Andrea B Bind, Marie-Abele C Flotte, Thomas J Cordon-Cardo, Carlos Decker, Lauren A Finn, Aloke V Padera, Robert F Reichard, R. Ross Stone, James R Adolphi, Natalie L Casimero, Faye Victoria C Crary, John F Elifritz, Jamie Faustin, Arline Ghosh, Saikat Kumar B Krausert, Amanda Martinez-Lage, Maria Melamed, Jonathan Mitchell, Roger A Sampson, Barbara A Seifert, Alan C Simsir, Aylin Adams, Cheryle Haasnoot, Stephanie Hafner, Stephanie Siciliano, Michelle A Vallejos, Brittany B Del Boccio, Phoebe Lamendola-Essel, Michelle F Young, Chloe E Kewlani, Deepshikha Akinbo, Precious A Parent, Brendan Chung, Alicia Cato, Teresa C Mudumbi, Praveen C Esquenazi-Karonika, Shari Wood, Marion J Chan, James Monteiro, Jonathan Shinnick, Daniel J Thaweethai, Tanayott Nguyen, Amber N Fitzgerald, Megan L Perlowski, Alice A Stiles, Lauren E Paskett, Moira L Katz, Stuart D Foulkes, Andrea S |
| description | Importance RECOVER-Pathology is a cross-sectional study of decedents dying at least 15 days following initial SARS-CoV-2 infection. Eligible decedents must meet WHO criteria for suspected, probable, or confirmed infection and must be aged 18 years or more at the time of death. Enrollment occurs at 7 sites in four U.S. states and Washington, DC. Comprehensive autopsies are conducted according to a standardized protocol within 24 hours of death; tissue samples are sent to the PASC Biorepository for later analyses. Data on clinical history are collected from the medical records and/or next of kin. The primary study outcomes include an array of pathologic features organized by organ system. Causal inference methods will be employed to investigate associations between risk factors and pathologic outcomes. RECOVER-Pathology is the largest autopsy study addressing PASC among US adults. Results of this study are intended to elucidate mechanisms of organ injury and disease and enhance our understanding of the pathophysiology of PASC. |
| doi_str_mv | 10.1371/journal.pone.0285645 |
| format | Article |
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Ross</au><au>Stone, James R</au><au>Adolphi, Natalie L</au><au>Casimero, Faye Victoria C</au><au>Crary, John F</au><au>Elifritz, Jamie</au><au>Faustin, Arline</au><au>Ghosh, Saikat Kumar B</au><au>Krausert, Amanda</au><au>Martinez-Lage, Maria</au><au>Melamed, Jonathan</au><au>Mitchell, Roger A</au><au>Sampson, Barbara A</au><au>Seifert, Alan C</au><au>Simsir, Aylin</au><au>Adams, Cheryle</au><au>Haasnoot, Stephanie</au><au>Hafner, Stephanie</au><au>Siciliano, Michelle A</au><au>Vallejos, Brittany B</au><au>Del Boccio, Phoebe</au><au>Lamendola-Essel, Michelle F</au><au>Young, Chloe E</au><au>Kewlani, Deepshikha</au><au>Akinbo, Precious A</au><au>Parent, Brendan</au><au>Chung, Alicia</au><au>Cato, Teresa C</au><au>Mudumbi, Praveen C</au><au>Esquenazi-Karonika, Shari</au><au>Wood, Marion J</au><au>Chan, James</au><au>Monteiro, Jonathan</au><au>Shinnick, Daniel J</au><au>Thaweethai, Tanayott</au><au>Nguyen, Amber N</au><au>Fitzgerald, Megan L</au><au>Perlowski, Alice A</au><au>Stiles, Lauren E</au><au>Paskett, Moira L</au><au>Katz, Stuart D</au><au>Foulkes, Andrea S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Researching COVID to enhance recovery</atitle><jtitle>PloS one</jtitle><date>2024-01-10</date><risdate>2024</risdate><volume>19</volume><issue>1</issue><spage>e0285645</spage><pages>e0285645-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Importance RECOVER-Pathology is a cross-sectional study of decedents dying at least 15 days following initial SARS-CoV-2 infection. Eligible decedents must meet WHO criteria for suspected, probable, or confirmed infection and must be aged 18 years or more at the time of death. Enrollment occurs at 7 sites in four U.S. states and Washington, DC. Comprehensive autopsies are conducted according to a standardized protocol within 24 hours of death; tissue samples are sent to the PASC Biorepository for later analyses. Data on clinical history are collected from the medical records and/or next of kin. The primary study outcomes include an array of pathologic features organized by organ system. Causal inference methods will be employed to investigate associations between risk factors and pathologic outcomes. RECOVER-Pathology is the largest autopsy study addressing PASC among US adults. Results of this study are intended to elucidate mechanisms of organ injury and disease and enhance our understanding of the pathophysiology of PASC.</abstract><pub>Public Library of Science</pub><doi>10.1371/journal.pone.0285645</doi><tpages>e0285645</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2024-01, Vol.19 (1), p.e0285645 |
| issn | 1932-6203 1932-6203 |
| language | eng |
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| source | Public Library of Science (PLoS) Journals Open Access; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Evaluation Mediation Medical records Medical research Medicine, Experimental |
| title | Researching COVID to enhance recovery |
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