Targeting macrophage M1 polarization suppression through PCAF inhibition alleviates autoimmune arthritis via synergistic NF-κB and H3K9Ac blockade

Sustained inflammatory invasion leads to joint damage and progressive disability in several autoimmune rheumatic diseases. In recent decades, targeting M1 macrophage polarization has been suggested as a promising therapeutic strategy for autoimmune arthritis. P300/CBP-associated factor (PCAF) is a h...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of nanobiotechnology 2023-08, Vol.21 (1)
Hauptverfasser:	Li, Jinteng, Ye, Feng, Xu, Xiaojun, Xu, Peitao, Wang, Peng, Zheng, Guan, Ye, Guiwen, Yu, Wenhui, Su, Zepeng, Lin, Jiajie, Che, Yunshu, Liu, Zhidong, Feng, Pei, Cao, Qian, Li, Dateng, Xie, Zhongyu, Wu, Yanfeng, Shen, Huiyong
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antiarthritic agents Arthritis Dextran Health aspects Histones Macrophages
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!