Novel report on congenital talipes equinovarus
Olanzapine is widely used during pregnancy to manage mood and psychotic disorders with overall beneficial effects. There have been past reports of olanzapine exposure during early pregnancy and clubfoot in two newborns from India and Israel. We report a woman in Nepal diagnosed with schizophrenia an...
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| Veröffentlicht in: | Archives of women's mental health 2022-06, Vol.25 (3), p.671 |
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| container_title | Archives of women's mental health |
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| creator | Baral, Ashok Upreti, Dikshya Gupta, Anoop Krishna Yadav, Chandra Bhushan Shoib, Sheikh Gyawali, Rajan Chandradasa, Miyuru |
| description | Olanzapine is widely used during pregnancy to manage mood and psychotic disorders with overall beneficial effects. There have been past reports of olanzapine exposure during early pregnancy and clubfoot in two newborns from India and Israel. We report a woman in Nepal diagnosed with schizophrenia and treated with olanzapine throughout the pregnancy delivering a baby boy with congenital talipes equinovarus deformity. Like in many other low-income settings, pregnancy was unplanned, and pre-conception counselling was not done. Research in mice has revealed the negative effects of olanzapine on bone development. Further reports would strengthen this potential association between exposure to olanzapine in the first trimester and the occurrence of clubfoot in the baby. |
| doi_str_mv | 10.1007/s00737-022-01221-z |
| format | Article |
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There have been past reports of olanzapine exposure during early pregnancy and clubfoot in two newborns from India and Israel. We report a woman in Nepal diagnosed with schizophrenia and treated with olanzapine throughout the pregnancy delivering a baby boy with congenital talipes equinovarus deformity. Like in many other low-income settings, pregnancy was unplanned, and pre-conception counselling was not done. Research in mice has revealed the negative effects of olanzapine on bone development. 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There have been past reports of olanzapine exposure during early pregnancy and clubfoot in two newborns from India and Israel. We report a woman in Nepal diagnosed with schizophrenia and treated with olanzapine throughout the pregnancy delivering a baby boy with congenital talipes equinovarus deformity. Like in many other low-income settings, pregnancy was unplanned, and pre-conception counselling was not done. Research in mice has revealed the negative effects of olanzapine on bone development. Further reports would strengthen this potential association between exposure to olanzapine in the first trimester and the occurrence of clubfoot in the baby.</description><subject>Bipolar disorder</subject><subject>Case studies</subject><subject>Clubfoot</subject><subject>Complications and side effects</subject><subject>Dosage and administration</subject><subject>Drug therapy</subject><subject>Olanzapine</subject><subject>Prenatal drug exposure</subject><subject>Risk factors</subject><subject>Schizophrenia</subject><issn>1434-1816</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpNjktLAzEUhbNQsFb_gKtZCS5Sb5LJa1mKj0JR0O6HOLmdjoSkTjJF_PUO6KJwHpuPwyHkhsGCAej7PIXQFDinwDhn9OeMzFgtasoMUxfkMudPAJDW1jOyeElHDNWAhzSUKsWqTbHD2BcXqsn9AXOFX2Mf09ENY74i5zsXMl7_95xsHx-2q2e6eX1ar5Yb2ikJFHeSC2FQeaytNy1K3grUtdRWWua4ElooL9Bb771QCgzyD-c888Zqw3diTu7-ZjsXsOnjdKrgd-ncmHOzfn9rlhr4JGZhYm9P2D26UPY5hbH0KeZT8BeJylJF</recordid><startdate>20220601</startdate><enddate>20220601</enddate><creator>Baral, Ashok</creator><creator>Upreti, Dikshya</creator><creator>Gupta, Anoop Krishna</creator><creator>Yadav, Chandra Bhushan</creator><creator>Shoib, Sheikh</creator><creator>Gyawali, Rajan</creator><creator>Chandradasa, Miyuru</creator><general>Springer</general><scope>ISR</scope></search><sort><creationdate>20220601</creationdate><title>Novel report on congenital talipes equinovarus</title><author>Baral, Ashok ; Upreti, Dikshya ; Gupta, Anoop Krishna ; Yadav, Chandra Bhushan ; Shoib, Sheikh ; Gyawali, Rajan ; Chandradasa, Miyuru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g650-ef52338e6de49d8ce52c3e74579591a263736d3ed9ddd36608e2baad1d89782f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Bipolar disorder</topic><topic>Case studies</topic><topic>Clubfoot</topic><topic>Complications and side effects</topic><topic>Dosage and administration</topic><topic>Drug therapy</topic><topic>Olanzapine</topic><topic>Prenatal drug exposure</topic><topic>Risk factors</topic><topic>Schizophrenia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baral, Ashok</creatorcontrib><creatorcontrib>Upreti, Dikshya</creatorcontrib><creatorcontrib>Gupta, Anoop Krishna</creatorcontrib><creatorcontrib>Yadav, Chandra Bhushan</creatorcontrib><creatorcontrib>Shoib, Sheikh</creatorcontrib><creatorcontrib>Gyawali, Rajan</creatorcontrib><creatorcontrib>Chandradasa, Miyuru</creatorcontrib><collection>Gale In Context: Science</collection><jtitle>Archives of women's mental health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baral, Ashok</au><au>Upreti, Dikshya</au><au>Gupta, Anoop Krishna</au><au>Yadav, Chandra Bhushan</au><au>Shoib, Sheikh</au><au>Gyawali, Rajan</au><au>Chandradasa, Miyuru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel report on congenital talipes equinovarus</atitle><jtitle>Archives of women's mental health</jtitle><date>2022-06-01</date><risdate>2022</risdate><volume>25</volume><issue>3</issue><spage>671</spage><pages>671-</pages><issn>1434-1816</issn><abstract>Olanzapine is widely used during pregnancy to manage mood and psychotic disorders with overall beneficial effects. 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| ispartof | Archives of women's mental health, 2022-06, Vol.25 (3), p.671 |
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| language | eng |
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| subjects | Bipolar disorder Case studies Clubfoot Complications and side effects Dosage and administration Drug therapy Olanzapine Prenatal drug exposure Risk factors Schizophrenia |
| title | Novel report on congenital talipes equinovarus |
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