The kinetic profiles of copeptin and mid regional proadrenomedullin
Kinetics of copeptin and mid regional proadrenomedullin (MR-proADM) during febrile pediatric lower respiratory tract infections (LRTI) are unknown. We aimed to analyze kinetic profiles of copeptin and MR-proADM and the impact of clinical and laboratory factors on those biomarkers. This is a retrospe...
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| Veröffentlicht in: | PloS one 2022-03, Vol.17 (3), p.e0264305 |
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| creator | Baumann, Philipp Fuchs, Aline Gotta, Verena Ritz, Nicole Baer, Gurli Bonhoeffer, Jessica M Buettcher, Michael Heininger, Ulrich Szinnai, Gabor Bonhoeffer, Jan |
| description | Kinetics of copeptin and mid regional proadrenomedullin (MR-proADM) during febrile pediatric lower respiratory tract infections (LRTI) are unknown. We aimed to analyze kinetic profiles of copeptin and MR-proADM and the impact of clinical and laboratory factors on those biomarkers. This is a retrospective post-hoc analysis of a randomized controlled trial, evaluating procalcitonin guidance for antibiotic treatment of LRTI (ProPAED-study). In 175 pediatric patients presenting to the emergency department plasma copeptin and MR-proADM concentrations were determined on day 1, 3, and 5. Their association with clinical characteristics and other inflammatory biomarkers were tested by non-linear mixed effect modelling. Median copeptin and MR-proADM values were elevated on day 1 and decreased during on day 3 and 5 (-26%; -34%, respectively). The initial concentrations of MR-proADM at inclusion were higher in patients receiving antibiotics intravenously compared to oral administration (difference 0.62 pmol/L, 95%CI 0.44;1.42, p |
| doi_str_mv | 10.1371/journal.pone.0264305 |
| format | Article |
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We aimed to analyze kinetic profiles of copeptin and MR-proADM and the impact of clinical and laboratory factors on those biomarkers. This is a retrospective post-hoc analysis of a randomized controlled trial, evaluating procalcitonin guidance for antibiotic treatment of LRTI (ProPAED-study). In 175 pediatric patients presenting to the emergency department plasma copeptin and MR-proADM concentrations were determined on day 1, 3, and 5. Their association with clinical characteristics and other inflammatory biomarkers were tested by non-linear mixed effect modelling. Median copeptin and MR-proADM values were elevated on day 1 and decreased during on day 3 and 5 (-26%; -34%, respectively). The initial concentrations of MR-proADM at inclusion were higher in patients receiving antibiotics intravenously compared to oral administration (difference 0.62 pmol/L, 95%CI 0.44;1.42, p<0.001). Intensive care unit (ICU) admission was associated with a daily increase of MR-proADM (increase/day 1.03 pmol/L, 95%CI 0.43;1.50, p<0.001). Positive blood culture in patients with antibiotic treatment and negative results on nasopharyngeal aspirates, or negative blood culture were associated with a decreasing MR-proADM (decrease/day -0.85 pmol/L, 95%CI -0.45;-1.44), p<0.001). Elevated MR-proADM and increases thereof were associated with ICU admission suggesting the potential as a prognostic factor for severe pediatric LRTI. MR-proADM might only bear limited value for decision making on stopping antibiotics due to its slow decrease. Copeptin had no added value in our setting.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0264305</identifier><language>eng</language><publisher>Public Library of Science</publisher><subject>Care and treatment ; Children ; Diagnosis ; Diseases ; Respiratory tract infections</subject><ispartof>PloS one, 2022-03, Vol.17 (3), p.e0264305</ispartof><rights>COPYRIGHT 2022 Public Library of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27924,27925</link.rule.ids></links><search><creatorcontrib>Baumann, Philipp</creatorcontrib><creatorcontrib>Fuchs, Aline</creatorcontrib><creatorcontrib>Gotta, Verena</creatorcontrib><creatorcontrib>Ritz, Nicole</creatorcontrib><creatorcontrib>Baer, Gurli</creatorcontrib><creatorcontrib>Bonhoeffer, Jessica M</creatorcontrib><creatorcontrib>Buettcher, Michael</creatorcontrib><creatorcontrib>Heininger, Ulrich</creatorcontrib><creatorcontrib>Szinnai, Gabor</creatorcontrib><creatorcontrib>Bonhoeffer, Jan</creatorcontrib><title>The kinetic profiles of copeptin and mid regional proadrenomedullin</title><title>PloS one</title><description>Kinetics of copeptin and mid regional proadrenomedullin (MR-proADM) during febrile pediatric lower respiratory tract infections (LRTI) are unknown. We aimed to analyze kinetic profiles of copeptin and MR-proADM and the impact of clinical and laboratory factors on those biomarkers. This is a retrospective post-hoc analysis of a randomized controlled trial, evaluating procalcitonin guidance for antibiotic treatment of LRTI (ProPAED-study). In 175 pediatric patients presenting to the emergency department plasma copeptin and MR-proADM concentrations were determined on day 1, 3, and 5. Their association with clinical characteristics and other inflammatory biomarkers were tested by non-linear mixed effect modelling. Median copeptin and MR-proADM values were elevated on day 1 and decreased during on day 3 and 5 (-26%; -34%, respectively). The initial concentrations of MR-proADM at inclusion were higher in patients receiving antibiotics intravenously compared to oral administration (difference 0.62 pmol/L, 95%CI 0.44;1.42, p<0.001). Intensive care unit (ICU) admission was associated with a daily increase of MR-proADM (increase/day 1.03 pmol/L, 95%CI 0.43;1.50, p<0.001). Positive blood culture in patients with antibiotic treatment and negative results on nasopharyngeal aspirates, or negative blood culture were associated with a decreasing MR-proADM (decrease/day -0.85 pmol/L, 95%CI -0.45;-1.44), p<0.001). Elevated MR-proADM and increases thereof were associated with ICU admission suggesting the potential as a prognostic factor for severe pediatric LRTI. MR-proADM might only bear limited value for decision making on stopping antibiotics due to its slow decrease. Copeptin had no added value in our setting.</description><subject>Care and treatment</subject><subject>Children</subject><subject>Diagnosis</subject><subject>Diseases</subject><subject>Respiratory tract infections</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNqFz0tLAzEUBeAgCtbqP3CRleBiah4zyWRZio9CoaDFbckkN9PUNBkmM-DPt6KLunJ1z-LjHC5Ct5TMKJf0YZ_GPuow61KEGWGi5KQ6QxOqOCsEI_z8JF-iq5z3hFS8FmKCFpsd4A8fYfAGd31yPkDGyWGTOugGH7GOFh-8xT20Ph1XvpW2PcR0ADuG4OM1unA6ZLj5vVO0eXrcLF6K1fp5uZivilYpVtRW6KqWllGthCGOMlEzJ42iFZMNbzgzpSVNXUrCHVdMSg2NY6VkyrAKKj5F9z-1rQ6w9dGkOMDn0Oox5-3y7XU7F0pwzlXJ_rHr97_27sTuQIdhl1MYh-O7-RR-Afuyazw</recordid><startdate>20220310</startdate><enddate>20220310</enddate><creator>Baumann, Philipp</creator><creator>Fuchs, Aline</creator><creator>Gotta, Verena</creator><creator>Ritz, Nicole</creator><creator>Baer, Gurli</creator><creator>Bonhoeffer, Jessica M</creator><creator>Buettcher, Michael</creator><creator>Heininger, Ulrich</creator><creator>Szinnai, Gabor</creator><creator>Bonhoeffer, Jan</creator><general>Public Library of Science</general><scope>IOV</scope><scope>ISR</scope></search><sort><creationdate>20220310</creationdate><title>The kinetic profiles of copeptin and mid regional proadrenomedullin</title><author>Baumann, Philipp ; Fuchs, Aline ; Gotta, Verena ; Ritz, Nicole ; Baer, Gurli ; Bonhoeffer, Jessica M ; Buettcher, Michael ; Heininger, Ulrich ; Szinnai, Gabor ; Bonhoeffer, Jan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g992-8d6a587d21a96c0f12682f7c91527b3b32c4d0b84703f39277aebf24729c25e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Care and treatment</topic><topic>Children</topic><topic>Diagnosis</topic><topic>Diseases</topic><topic>Respiratory tract infections</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baumann, Philipp</creatorcontrib><creatorcontrib>Fuchs, Aline</creatorcontrib><creatorcontrib>Gotta, Verena</creatorcontrib><creatorcontrib>Ritz, Nicole</creatorcontrib><creatorcontrib>Baer, Gurli</creatorcontrib><creatorcontrib>Bonhoeffer, Jessica M</creatorcontrib><creatorcontrib>Buettcher, Michael</creatorcontrib><creatorcontrib>Heininger, Ulrich</creatorcontrib><creatorcontrib>Szinnai, Gabor</creatorcontrib><creatorcontrib>Bonhoeffer, Jan</creatorcontrib><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baumann, Philipp</au><au>Fuchs, Aline</au><au>Gotta, Verena</au><au>Ritz, Nicole</au><au>Baer, Gurli</au><au>Bonhoeffer, Jessica M</au><au>Buettcher, Michael</au><au>Heininger, Ulrich</au><au>Szinnai, Gabor</au><au>Bonhoeffer, Jan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The kinetic profiles of copeptin and mid regional proadrenomedullin</atitle><jtitle>PloS one</jtitle><date>2022-03-10</date><risdate>2022</risdate><volume>17</volume><issue>3</issue><spage>e0264305</spage><pages>e0264305-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Kinetics of copeptin and mid regional proadrenomedullin (MR-proADM) during febrile pediatric lower respiratory tract infections (LRTI) are unknown. We aimed to analyze kinetic profiles of copeptin and MR-proADM and the impact of clinical and laboratory factors on those biomarkers. This is a retrospective post-hoc analysis of a randomized controlled trial, evaluating procalcitonin guidance for antibiotic treatment of LRTI (ProPAED-study). In 175 pediatric patients presenting to the emergency department plasma copeptin and MR-proADM concentrations were determined on day 1, 3, and 5. Their association with clinical characteristics and other inflammatory biomarkers were tested by non-linear mixed effect modelling. Median copeptin and MR-proADM values were elevated on day 1 and decreased during on day 3 and 5 (-26%; -34%, respectively). The initial concentrations of MR-proADM at inclusion were higher in patients receiving antibiotics intravenously compared to oral administration (difference 0.62 pmol/L, 95%CI 0.44;1.42, p<0.001). Intensive care unit (ICU) admission was associated with a daily increase of MR-proADM (increase/day 1.03 pmol/L, 95%CI 0.43;1.50, p<0.001). Positive blood culture in patients with antibiotic treatment and negative results on nasopharyngeal aspirates, or negative blood culture were associated with a decreasing MR-proADM (decrease/day -0.85 pmol/L, 95%CI -0.45;-1.44), p<0.001). Elevated MR-proADM and increases thereof were associated with ICU admission suggesting the potential as a prognostic factor for severe pediatric LRTI. MR-proADM might only bear limited value for decision making on stopping antibiotics due to its slow decrease. Copeptin had no added value in our setting.</abstract><pub>Public Library of Science</pub><doi>10.1371/journal.pone.0264305</doi><tpages>e0264305</tpages></addata></record> |
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| subjects | Care and treatment Children Diagnosis Diseases Respiratory tract infections |
| title | The kinetic profiles of copeptin and mid regional proadrenomedullin |
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