Proopiomelanocortin Processing in the Hypothalamus Is Directly Regulated by Saturated Fat: Implications for the Development of Obesity

In outbred mice, susceptibility or resistance to diet-induced obesity is associated with rapid changes in hypothalamic proopiomelanocortin (POMC) levels. Here, we evaluated 3 hypotheses that potentially explain the development of the different obesity phenotypes in outbred Swiss mice. First, rapid a...

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Veröffentlicht in:	Neuroendocrinology 2020-01, Vol.110 (1-2), p.92-104
Hauptverfasser:	Razolli, Daniela S., de Araújo, Thiago M., Sant'Ana, Marcella R., Kirwan, Peter, Cintra, Dennys E., Merkle, Florian T., Velloso, Licio A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Development and progression Diet, High-Fat Disease Models, Animal Fatty acids Gastrointestinal Microbiome Health aspects Humans Hypothalamus - metabolism Inflammation - metabolism Linoleic Acid - pharmacology Male Mice Neurons - metabolism Obesity Obesity - blood Obesity - etiology Obesity - metabolism Palmitates - pharmacology Pluripotent Stem Cells Pro-opiomelanocortin Pro-Opiomelanocortin - metabolism Research Article Risk factors RNA, Ribosomal, 16S
Online-Zugang:	Volltext
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