Acadesine suppresses TNF-[alpha] induced complement component 3

Age-related macular degeneration (AMD) is the most prevalent form of irreversible blindness in the developed world. Aging, inflammation and complement dysregulation affecting the retinal pigment epithelium (RPE), are considered significant contributors in its pathogenesis and several evidences have...

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Veröffentlicht in:	PloS one 2020-12, Vol.15 (12), p.e0244307
Hauptverfasser:	Efstathiou, Nikolaos E, Moustafa, Giannis A, Maidana, Daniel E, Konstantinou, Eleni K, Notomi, Shoji, Barbisan, Paulo R. T, Georgakopoulos, Constantine D, Miller, Joan W, Vavvas, Demetrios G
Format:	Artikel
Sprache:	eng
Schlagworte:	Complement system Development and progression Health aspects Macular degeneration Nucleoside analogs Physiological aspects Retinal pigment epithelium Tumor necrosis factor
Online-Zugang:	Volltext
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