Dedicated transcriptomics combined with power analysis lead to functional understanding of genes with weak phenotypic changes in knockout lines

Systematic knockout studies in mice have shown that a large fraction of the gene replacements show no lethal or other overt phenotypes. This has led to the development of more refined analysis schemes, including physiological, behavioral, developmental and cytological tests. However, transcriptomic...

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Veröffentlicht in:	PLoS computational biology 2020-11, Vol.16 (11), p.e1008354-e1008354
Hauptverfasser:	Xie, Chen, Bekpen, Cemalettin, Künzel, Sven, Keshavarz, Maryam, Krebs-Wheaton, Rebecca, Skrabar, Neva, Ullrich, Kristian K, Zhang, Wenyu, Tautz, Diethard
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Annotations Behavior, Animal Biology and Life Sciences Computational Biology Consortia Data processing Engineering and Technology Evolution Extremities - anatomy & histology Female Gene expression Gene Expression Profiling - methods Gene Expression Profiling - statistics & numerical data Gene Knockout Techniques Genes Genetic Association Studies - methods Genetic Association Studies - statistics & numerical data Genomes Genotype & phenotype Male Medicine and Health Sciences Mice Mice, Inbred C57BL Mice, Knockout Models, Genetic Non-coding RNA Opera Phenotype Phenotypes Phenotyping Proof of Concept Study Research and analysis methods Ribonucleic acid RNA RNA-Seq - statistics & numerical data Transcription (Genetics) Transcriptome Transcriptomes
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