Treatment of spinal cord injury with mesenchymal stem cells
Background Spinal cord injury (SCI) is the damage to the spinal cord that can lead to temporary or permanent loss of function due to injury to the nerve. The SCI patients are often associated with poor quality of life. Results This review discusses the current status of mesenchymal stem cell (MSC) t...
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| description | Background Spinal cord injury (SCI) is the damage to the spinal cord that can lead to temporary or permanent loss of function due to injury to the nerve. The SCI patients are often associated with poor quality of life. Results This review discusses the current status of mesenchymal stem cell (MSC) therapy for SCI, criteria to considering for the application of MSC therapy and novel biological therapies that can be applied together with MSCs to enhance its efficacy. Bone marrow-derived MSCs (BMSCs), umbilical cord-derived MSCs (UC-MSCs) and adipose tissue-derived MSCs (ADSCs) have been trialed for the treatment of SCI. Application of MSCs may minimize secondary injury to the spinal cord and protect the neural elements that survived the initial mechanical insult by suppressing the inflammation. Additionally, MSCs have been shown to differentiate into neuron-like cells and stimulate neural stem cell proliferation to rebuild the damaged nerve tissue. Conclusion These characteristics are crucial for the restoration of spinal cord function upon SCI as damaged cord has limited regenerative capacity and it is also something that cannot be achieved by pharmacological and physiotherapy interventions. New biological therapies including stem cell secretome therapy, immunotherapy and scaffolds can be combined with MSC therapy to enhance its therapeutic effects. |
| doi_str_mv | 10.1186/s13578-020-00475-3 |
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The SCI patients are often associated with poor quality of life. Results This review discusses the current status of mesenchymal stem cell (MSC) therapy for SCI, criteria to considering for the application of MSC therapy and novel biological therapies that can be applied together with MSCs to enhance its efficacy. Bone marrow-derived MSCs (BMSCs), umbilical cord-derived MSCs (UC-MSCs) and adipose tissue-derived MSCs (ADSCs) have been trialed for the treatment of SCI. Application of MSCs may minimize secondary injury to the spinal cord and protect the neural elements that survived the initial mechanical insult by suppressing the inflammation. Additionally, MSCs have been shown to differentiate into neuron-like cells and stimulate neural stem cell proliferation to rebuild the damaged nerve tissue. Conclusion These characteristics are crucial for the restoration of spinal cord function upon SCI as damaged cord has limited regenerative capacity and it is also something that cannot be achieved by pharmacological and physiotherapy interventions. New biological therapies including stem cell secretome therapy, immunotherapy and scaffolds can be combined with MSC therapy to enhance its therapeutic effects.</description><identifier>ISSN: 2045-3701</identifier><identifier>EISSN: 2045-3701</identifier><identifier>DOI: 10.1186/s13578-020-00475-3</identifier><identifier>PMID: 32983406</identifier><language>eng</language><publisher>LONDON: Springer Nature</publisher><subject>Adipose tissue ; Adipose tissues ; Biochemistry & Molecular Biology ; Bone marrow ; Care and treatment ; Cell differentiation ; Cell proliferation ; Clinical trials ; Immunotherapy ; Inflammation ; Life Sciences & Biomedicine ; Mesenchymal stem cells ; Nerve regeneration ; Nervous system ; Neural stem cells ; Neurons ; Paralysis ; Pathophysiology ; Physical therapy ; Quality of life ; Review ; Scars ; Science & Technology ; Secretome ; Spinal cord injuries ; Spinal cord injury ; Stem cell therapy ; Stem cells ; Therapeutics, Physiological ; Transplantation ; Umbilical cord</subject><ispartof>Cell & bioscience, 2020-09, Vol.10 (1), p.112-112, Article 112</ispartof><rights>The Author(s) 2020.</rights><rights>COPYRIGHT 2020 BioMed Central Ltd.</rights><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>128</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000574498700001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c597t-d82beff3d15dd6b4f1a80b43eb0f8e721a7e7a38836e29c4a39c568f97d0e1793</citedby><cites>FETCH-LOGICAL-c597t-d82beff3d15dd6b4f1a80b43eb0f8e721a7e7a38836e29c4a39c568f97d0e1793</cites><orcidid>0000-0001-9045-5145</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510077/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510077/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,2104,2116,27931,27932,28255,53798,53800</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32983406$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liau, Ling Ling</creatorcontrib><creatorcontrib>Looi, Qi Hao</creatorcontrib><creatorcontrib>Chia, Wui Chuen</creatorcontrib><creatorcontrib>Subramaniam, Thayaalini</creatorcontrib><creatorcontrib>Ng, Min Hwei</creatorcontrib><creatorcontrib>Law, Jia Xian</creatorcontrib><title>Treatment of spinal cord injury with mesenchymal stem cells</title><title>Cell & bioscience</title><addtitle>CELL BIOSCI</addtitle><addtitle>Cell Biosci</addtitle><description>Background Spinal cord injury (SCI) is the damage to the spinal cord that can lead to temporary or permanent loss of function due to injury to the nerve. The SCI patients are often associated with poor quality of life. Results This review discusses the current status of mesenchymal stem cell (MSC) therapy for SCI, criteria to considering for the application of MSC therapy and novel biological therapies that can be applied together with MSCs to enhance its efficacy. Bone marrow-derived MSCs (BMSCs), umbilical cord-derived MSCs (UC-MSCs) and adipose tissue-derived MSCs (ADSCs) have been trialed for the treatment of SCI. Application of MSCs may minimize secondary injury to the spinal cord and protect the neural elements that survived the initial mechanical insult by suppressing the inflammation. Additionally, MSCs have been shown to differentiate into neuron-like cells and stimulate neural stem cell proliferation to rebuild the damaged nerve tissue. Conclusion These characteristics are crucial for the restoration of spinal cord function upon SCI as damaged cord has limited regenerative capacity and it is also something that cannot be achieved by pharmacological and physiotherapy interventions. New biological therapies including stem cell secretome therapy, immunotherapy and scaffolds can be combined with MSC therapy to enhance its therapeutic effects.</description><subject>Adipose tissue</subject><subject>Adipose tissues</subject><subject>Biochemistry & Molecular Biology</subject><subject>Bone marrow</subject><subject>Care and treatment</subject><subject>Cell differentiation</subject><subject>Cell proliferation</subject><subject>Clinical trials</subject><subject>Immunotherapy</subject><subject>Inflammation</subject><subject>Life Sciences & Biomedicine</subject><subject>Mesenchymal stem cells</subject><subject>Nerve regeneration</subject><subject>Nervous system</subject><subject>Neural stem cells</subject><subject>Neurons</subject><subject>Paralysis</subject><subject>Pathophysiology</subject><subject>Physical therapy</subject><subject>Quality of life</subject><subject>Review</subject><subject>Scars</subject><subject>Science & Technology</subject><subject>Secretome</subject><subject>Spinal cord injuries</subject><subject>Spinal cord injury</subject><subject>Stem cell therapy</subject><subject>Stem cells</subject><subject>Therapeutics, Physiological</subject><subject>Transplantation</subject><subject>Umbilical cord</subject><issn>2045-3701</issn><issn>2045-3701</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl2L1DAYhYso7rLuH_BCCt4o0jXfaRAWlsGPgQVB1-uQpm9mMrTN2KSu8-9Nd9ZxR7wwvUhInnPKezhF8RyjC4xr8TZiymVdIYIqhJjkFX1UnBLE8kEi_PjB-aQ4j3GD8mIKI8mfFieUqJoyJE6LdzcjmNTDkMrgyrj1g-lKG8a29MNmGnflrU_rsocIg13v-vwYE_Slha6Lz4onznQRzu_3s-Lbh_c3i0_V9eePy8XVdWW5kqlqa9KAc7TFvG1Fwxw2NWoYhQa5GiTBRoI0tK6pAKIsM1RZLmqnZIsAS0XPiuXetw1mo7ej782408F4fXcRxpU2Y_K2A20VZQ2irm2aNs8nlSNOEGaQ4oxDQ7PX5d5rOzU9tDYPPpruyPT4ZfBrvQo_tOQYISmzwat7gzF8nyAm3fs4x2EGCFPUhDGhFJZoRl_-hW7CNOaAZ4pjRRQX6A-1MnkAP7iQ_2tnU30lqFCIYCEydfEPKn8t9N6GAZzP90eC10eCzCT4mVZmilEvv345ZsmetWOIcQR3yAMjPbdN79umc9v0Xdv0nOSLh0keJL-7lYF6D9xCE1y0PlcIDliuI5eMqVrOzcQLn0zyYViEaUhZ-ub_pfQX58Xtcw</recordid><startdate>20200922</startdate><enddate>20200922</enddate><creator>Liau, Ling Ling</creator><creator>Looi, Qi Hao</creator><creator>Chia, Wui Chuen</creator><creator>Subramaniam, Thayaalini</creator><creator>Ng, Min Hwei</creator><creator>Law, Jia Xian</creator><general>Springer Nature</general><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-9045-5145</orcidid></search><sort><creationdate>20200922</creationdate><title>Treatment of spinal cord injury with mesenchymal stem cells</title><author>Liau, Ling Ling ; Looi, Qi Hao ; Chia, Wui Chuen ; Subramaniam, Thayaalini ; Ng, Min Hwei ; Law, Jia Xian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c597t-d82beff3d15dd6b4f1a80b43eb0f8e721a7e7a38836e29c4a39c568f97d0e1793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adipose tissue</topic><topic>Adipose tissues</topic><topic>Biochemistry & Molecular Biology</topic><topic>Bone marrow</topic><topic>Care and treatment</topic><topic>Cell differentiation</topic><topic>Cell proliferation</topic><topic>Clinical trials</topic><topic>Immunotherapy</topic><topic>Inflammation</topic><topic>Life Sciences & Biomedicine</topic><topic>Mesenchymal stem cells</topic><topic>Nerve regeneration</topic><topic>Nervous system</topic><topic>Neural stem cells</topic><topic>Neurons</topic><topic>Paralysis</topic><topic>Pathophysiology</topic><topic>Physical therapy</topic><topic>Quality of life</topic><topic>Review</topic><topic>Scars</topic><topic>Science & Technology</topic><topic>Secretome</topic><topic>Spinal cord injuries</topic><topic>Spinal cord injury</topic><topic>Stem cell therapy</topic><topic>Stem cells</topic><topic>Therapeutics, Physiological</topic><topic>Transplantation</topic><topic>Umbilical cord</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liau, Ling Ling</creatorcontrib><creatorcontrib>Looi, Qi Hao</creatorcontrib><creatorcontrib>Chia, Wui Chuen</creatorcontrib><creatorcontrib>Subramaniam, Thayaalini</creatorcontrib><creatorcontrib>Ng, Min Hwei</creatorcontrib><creatorcontrib>Law, Jia Xian</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Cell & bioscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liau, Ling Ling</au><au>Looi, Qi Hao</au><au>Chia, Wui Chuen</au><au>Subramaniam, Thayaalini</au><au>Ng, Min Hwei</au><au>Law, Jia Xian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment of spinal cord injury with mesenchymal stem cells</atitle><jtitle>Cell & bioscience</jtitle><stitle>CELL BIOSCI</stitle><addtitle>Cell Biosci</addtitle><date>2020-09-22</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>112</spage><epage>112</epage><pages>112-112</pages><artnum>112</artnum><issn>2045-3701</issn><eissn>2045-3701</eissn><abstract>Background Spinal cord injury (SCI) is the damage to the spinal cord that can lead to temporary or permanent loss of function due to injury to the nerve. The SCI patients are often associated with poor quality of life. Results This review discusses the current status of mesenchymal stem cell (MSC) therapy for SCI, criteria to considering for the application of MSC therapy and novel biological therapies that can be applied together with MSCs to enhance its efficacy. Bone marrow-derived MSCs (BMSCs), umbilical cord-derived MSCs (UC-MSCs) and adipose tissue-derived MSCs (ADSCs) have been trialed for the treatment of SCI. Application of MSCs may minimize secondary injury to the spinal cord and protect the neural elements that survived the initial mechanical insult by suppressing the inflammation. Additionally, MSCs have been shown to differentiate into neuron-like cells and stimulate neural stem cell proliferation to rebuild the damaged nerve tissue. Conclusion These characteristics are crucial for the restoration of spinal cord function upon SCI as damaged cord has limited regenerative capacity and it is also something that cannot be achieved by pharmacological and physiotherapy interventions. New biological therapies including stem cell secretome therapy, immunotherapy and scaffolds can be combined with MSC therapy to enhance its therapeutic effects.</abstract><cop>LONDON</cop><pub>Springer Nature</pub><pmid>32983406</pmid><doi>10.1186/s13578-020-00475-3</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0001-9045-5145</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adipose tissue Adipose tissues Biochemistry & Molecular Biology Bone marrow Care and treatment Cell differentiation Cell proliferation Clinical trials Immunotherapy Inflammation Life Sciences & Biomedicine Mesenchymal stem cells Nerve regeneration Nervous system Neural stem cells Neurons Paralysis Pathophysiology Physical therapy Quality of life Review Scars Science & Technology Secretome Spinal cord injuries Spinal cord injury Stem cell therapy Stem cells Therapeutics, Physiological Transplantation Umbilical cord |
| title | Treatment of spinal cord injury with mesenchymal stem cells |
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