Bidirectional interaction between intestinal microbiome and cancer: opportunities for therapeutic interventions
Gut microbiota composition influences the balance between human health and disease. Increasing evidence suggests the involvement of microbial factors in regulating cancer development, progression, and therapeutic response. Distinct microbial species have been implicated in modulating gut environment...
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| Veröffentlicht in: | Biomarker research 2020-08, Vol.8 (1), p.1-31, Article 31 |
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| description | Gut microbiota composition influences the balance between human health and disease. Increasing evidence suggests the involvement of microbial factors in regulating cancer development, progression, and therapeutic response. Distinct microbial species have been implicated in modulating gut environment and architecture that affects cancer therapy outcomes. While some microbial species offer enhanced cancer therapy response, others diminish cancer treatment efficacy. In addition, use of antibiotics, often to minimize infection risks in cancer, causes intestinal dysbiosis and proves detrimental. In this review we discuss the role of gut microbiota in cancer development and therapy. We also provide insights into future strategies to manipulate the microbiome and gut epithelial barrier to augment therapeutic responses while minimizing toxicity or infection risks. |
| doi_str_mv | 10.1186/s40364-020-00211-6 |
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Increasing evidence suggests the involvement of microbial factors in regulating cancer development, progression, and therapeutic response. Distinct microbial species have been implicated in modulating gut environment and architecture that affects cancer therapy outcomes. While some microbial species offer enhanced cancer therapy response, others diminish cancer treatment efficacy. In addition, use of antibiotics, often to minimize infection risks in cancer, causes intestinal dysbiosis and proves detrimental. In this review we discuss the role of gut microbiota in cancer development and therapy. 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Increasing evidence suggests the involvement of microbial factors in regulating cancer development, progression, and therapeutic response. Distinct microbial species have been implicated in modulating gut environment and architecture that affects cancer therapy outcomes. While some microbial species offer enhanced cancer therapy response, others diminish cancer treatment efficacy. In addition, use of antibiotics, often to minimize infection risks in cancer, causes intestinal dysbiosis and proves detrimental. In this review we discuss the role of gut microbiota in cancer development and therapy. We also provide insights into future strategies to manipulate the microbiome and gut epithelial barrier to augment therapeutic responses while minimizing toxicity or infection risks.</description><subject>Adaptive immunity</subject><subject>Antibiotics</subject><subject>B cells</subject><subject>Bacteria</subject><subject>Cancer</subject><subject>Cancer development</subject><subject>Cancer therapies</subject><subject>Cancer therapy</subject><subject>Care and treatment</subject><subject>Colorectal cancer</subject><subject>Deoxyribonucleic acid</subject><subject>Digestive system</subject><subject>DNA</subject><subject>Dysbacteriosis</subject><subject>Gastrointestinal tract</subject><subject>Gram-positive bacteria</subject><subject>Health aspects</subject><subject>Homeostasis</subject><subject>Infection control</subject><subject>Inflammation</subject><subject>Intestinal dysbiosis</subject><subject>Intestinal microflora</subject><subject>Intestine</subject><subject>Leukemia</subject><subject>Life Sciences & Biomedicine</subject><subject>Liver cancer</subject><subject>Lung cancer</subject><subject>Lymphoma</subject><subject>Medicine, Research & Experimental</subject><subject>Metabolism</subject><subject>Microbial therapy</subject><subject>Microbiomes</subject><subject>Microbiota</subject><subject>Microbiota (Symbiotic organisms)</subject><subject>Oncology</subject><subject>Pancreatic cancer</subject><subject>Permeability</subject><subject>Research & Experimental Medicine</subject><subject>Review</subject><subject>Science & Technology</subject><subject>Therapeutic applications</subject><subject>Toxicity</subject><subject>Tumor necrosis factor-TNF</subject><issn>2050-7771</issn><issn>2050-7771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkktv1DAUhSMEotXQP8AqEhsQSvHbDgukMuIxUiUk6N5ynJupq4w92E4L_x5nUhUGsSBZJLk-54t976mq5xidY6zEm8QQFaxBBDUIEYwb8ag6JYijRkqJH__xflKdpXSDyqUUw7h9Wp1QorCULT2twnvXuwg2u-DNWDufIZrDV91BvgPwh1rKbl7eORtD58IOauP72hpvIb6tw34fYp68yw5SPYRY5-uC2cOUnV2Yt-BnaHpWPRnMmODs_rmqrj5-uFp_bi6_fNqsLy4byyXLDeMM2R6p1jJJJYDCtBuo6I2hQyslMQITbkmP205Ro3qweMB0QK1VCBijq2qzYPtgbvQ-up2JP3UwTh8KIW61iWVzI2jLMRjZGyGQZQO2hiupCFje4Q6TVhXWu4W1n7od9LacJJrxCHq84t213oZbLRlhoux8Vb28B8TwfSq91DuXLIyj8RCmpAkrk0QUYV6kL_6S3oQpltYfVByTeWq_VVtTDuD8EMp_7QzVF4JSJBHjM-v8H6py91DmGDwMrtSPDK-ODEWT4Ufemiklvfn29VhLFm0JREoRhod-YKTngOoloLoEVB8CqkUxqcV0B10YknVQ8vNgLAHlgjKm5JxVunbZzJFZh8nnYn39_1b6C5lM99U</recordid><startdate>20200812</startdate><enddate>20200812</enddate><creator>Dutta, Dibyendu</creator><creator>Lim, Seah H.</creator><general>Springer Nature</general><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-4135-5989</orcidid></search><sort><creationdate>20200812</creationdate><title>Bidirectional interaction between intestinal microbiome and cancer: opportunities for therapeutic interventions</title><author>Dutta, Dibyendu ; 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Increasing evidence suggests the involvement of microbial factors in regulating cancer development, progression, and therapeutic response. Distinct microbial species have been implicated in modulating gut environment and architecture that affects cancer therapy outcomes. While some microbial species offer enhanced cancer therapy response, others diminish cancer treatment efficacy. In addition, use of antibiotics, often to minimize infection risks in cancer, causes intestinal dysbiosis and proves detrimental. In this review we discuss the role of gut microbiota in cancer development and therapy. 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| subjects | Adaptive immunity Antibiotics B cells Bacteria Cancer Cancer development Cancer therapies Cancer therapy Care and treatment Colorectal cancer Deoxyribonucleic acid Digestive system DNA Dysbacteriosis Gastrointestinal tract Gram-positive bacteria Health aspects Homeostasis Infection control Inflammation Intestinal dysbiosis Intestinal microflora Intestine Leukemia Life Sciences & Biomedicine Liver cancer Lung cancer Lymphoma Medicine, Research & Experimental Metabolism Microbial therapy Microbiomes Microbiota Microbiota (Symbiotic organisms) Oncology Pancreatic cancer Permeability Research & Experimental Medicine Review Science & Technology Therapeutic applications Toxicity Tumor necrosis factor-TNF |
| title | Bidirectional interaction between intestinal microbiome and cancer: opportunities for therapeutic interventions |
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