Neutralizing Antibodies against Enteroviruses in Patients with Hand, Foot and Mouth Disease

Hand, foot and mouth disease (HFMD) is an emerging infection with pandemic potential. Knowledge of neutralizing antibody responses among its pathogens is essential to inform vaccine development and epidemiologic research. We used 120 paired-plasma samples collected at enrollment and >7 days after...

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Veröffentlicht in:	Emerging infectious diseases 2020-02, Vol.26 (2), p.298-306
Hauptverfasser:	Lam Anh Nguyet, Tran Tan Thanh, Le Nguyen Thanh Nhan, Nguyen Thi Thu Hong, Le Nguyen Truc Nhu, Hoang Minh Tu Van, Nguyen Thi Han Ny, Nguyen To Anh, Do Duong Kim Han, Ha Manh Tuan, Vu Quang Huy, Ho Lu Viet, Hoang Quoc Cuong, Nguyen Thi Thanh Thao, Do Chau Viet, Truong Huu Khanh, Thwaites, Louise, Clapham, Hannah, Nguyen Thanh Hung, Nguyen Van Vinh Chau, Thwaites, Guy, Do Quang Ha, van Doorn, H. Rogier, Le Van Tan
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antibodies, Neutralizing - immunology Ataxia Care and treatment Child Child, Preschool coxsackievirus Coxsackievirus infections Diseases Enrollments enterovirus Enterovirus - immunology enterovirus A71 and neutralization Epidemics Female Fever Foot and mouth disease hand Hand, Foot and Mouth Disease - blood Hand, Foot and Mouth Disease - epidemiology Hand, Foot and Mouth Disease - prevention & control Hand, Foot and Mouth Disease - virology Health aspects Hospitals Humans Illnesses Immunology Infant Infant, Newborn Infection Infections Infectious Diseases Life Sciences & Biomedicine Male Medical research Nervous system Neutralizing Antibodies against Enteroviruses in Patients with Hand, Foot and Mouth Disease Pathogenic microorganisms Pathogens Patients Plasma Science & Technology Vaccines Variance analysis Vietnam - epidemiology Viral Vaccines viruses
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Beschreibung
Zusammenfassung:	Hand, foot and mouth disease (HFMD) is an emerging infection with pandemic potential. Knowledge of neutralizing antibody responses among its pathogens is essential to inform vaccine development and epidemiologic research. We used 120 paired-plasma samples collected at enrollment and >7 days after the onset of illness from HFMD patients infected with enterovirus A71 (EV-A71), coxsackievirus A (CVA) 6, CVA10, and CVA16 to study cross-neutralization. For homotypic viruses, seropositivity increased from
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid2602.190721