The CSF-1-receptor inhibitor, JNJ-40346527

Originally believed to be primarily a disorder of T-cell signaling, evidence shows that macrophage-lineage cells also contribute to the pathogenesis of Crohn's disease (CD). Colony stimulating factor-1 (CSF-1) is a key regulator of the macrophage lineage, but its role in CD has not been well es...

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Veröffentlicht in:	PloS one 2019-11, Vol.14 (11), p.e0223918
Hauptverfasser:	Manthey, Carl L, Moore, Beverley A, Chen, Yanqing, Loza, Matthew J, Yao, Xiang, Liu, Hao, Belkowski, Stanley M, Raymond-Parks, Holly, Dunford, Paul J, Leon, Francisco, Towne, Jennifer E, Plevy, Scott E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adalimumab Analysis Blood tests Colitis Gastrointestinal diseases Gene expression Genes Genetic research Histochemistry House mouse Immunohistochemistry Lymphocytes Macrophages RNA sequencing T cells
Online-Zugang:	Volltext
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