A tethered-inchworm model of SMC DNA translocation
The DNA loop extrusion model is a provocative new concept explaining the formation of chromatin loops that revolutionizes understanding of genome organization. Central to this model is the structural maintenance of chromosomes (SMC) protein family, which is now thought to function as a DNA motor. In...
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| Veröffentlicht in: | Nature Structural and Molecular Biology 2018, Vol.25 (10), p.906 |
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| container_issue | 10 |
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| container_title | Nature Structural and Molecular Biology |
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| creator | Nichols, Michael H Corces, Victor G |
| description | The DNA loop extrusion model is a provocative new concept explaining the formation of chromatin loops that revolutionizes understanding of genome organization. Central to this model is the structural maintenance of chromosomes (SMC) protein family, which is now thought to function as a DNA motor. In this Perspective, we review and reinterpret the current knowledge of SMC structure and function and propose a novel mechanism for SMC motor activity. |
| doi_str_mv | 10.1038/s41594-018-0135-4 |
| format | Report |
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Central to this model is the structural maintenance of chromosomes (SMC) protein family, which is now thought to function as a DNA motor. In this Perspective, we review and reinterpret the current knowledge of SMC structure and function and propose a novel mechanism for SMC motor activity.</abstract><pub>Nature Publishing Group</pub><doi>10.1038/s41594-018-0135-4</doi><tpages>906</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1545-9993 |
| ispartof | Nature Structural and Molecular Biology, 2018, Vol.25 (10), p.906 |
| issn | 1545-9993 |
| language | eng |
| recordid | cdi_gale_incontextgauss_ISR_A593382183 |
| source | Springer Nature - Complete Springer Journals; Nature Journals Online |
| subjects | Chromatin Chromosomes DNA Genetic aspects Genomes Genomics Mitosis Novels |
| title | A tethered-inchworm model of SMC DNA translocation |
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