Blockade of the Programmed Death-1

Inhibition of PD1-PDL1 signaling in NOD mice accelerates onset of type 1 diabetes implicating this pathway in suppressing the emergence of pancreatic beta cell reactive T-cells. However, the molecular mechanism by which PD1 signaling protects from type 1 diabetes is not clear. We hypothesized that d...

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Veröffentlicht in:	PloS one 2014-02, Vol.9 (2), p.e89561
Hauptverfasser:	Kochupurakkal, Nora M, Kruger, Annie J, Tripathi, Sudipta, Zhu, Bing, Adams, La Tonya, Rainbow, Daniel B, Rossini, Aldo, Greiner, Dale L, Sayegh, Mohamed H, Wicker, Linda S, Guleria, Indira
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood glucose Genes Genetic aspects Pancreatic beta cells T cells Type 1 diabetes
Online-Zugang:	Volltext
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