Studies on New Activities of Enantiomers of 2
R-/S-2-(2-Hydroxypropanamido) benzoic acid (R-/S-HPABA), a marine-derived anti-inflammatory drug, however, the antiplatelet and antithrombotic effects have not been investigated. In this paper, the in vitro antiplatelet activities and in vivo antithrombotic effects of R-/S-HPABA were investigated, f...
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| Veröffentlicht in: | PloS one 2017-01, Vol.12 (1), p.e0170334 |
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| creator | Zhang, Qili Wang, Danlin Zhang, Meiyan Zhao, Yunli Yu, Zhiguo |
| description | R-/S-2-(2-Hydroxypropanamido) benzoic acid (R-/S-HPABA), a marine-derived anti-inflammatory drug, however, the antiplatelet and antithrombotic effects have not been investigated. In this paper, the in vitro antiplatelet activities and in vivo antithrombotic effects of R-/S-HPABA were investigated, for the first time. The effects of R-/S-HPABA on platelet aggregation induced by adenosine diphosphate (ADP), collagen (COLL) and arachidonic acid (AA) were evaluated. In addition, the in vivo bleeding time, clotting time, collagen-epinephrine induced pulmonary thrombosis and common carotid artery thrombosis were also investigated in rats. R-/S-HPABA significantly inhibited ADP, COLL and AA induced platelet aggregation in rabbit platelet rich plasma in vitro compared with control group, to a degree similar to that of aspirin. Besides, R-/S-HPABA prolonged bleeding time and clotting time as well as increased the recovery rate obviously in pulmonary thrombosis. Moreover, the level of thromboxane B.sub.2 (TXB.sub.2) was decreased while the production of 6-keto-prostaglandin F1[alpha] (6-keto-PGF1[alpha]) was increased markedly by R-/S-HPABA. Furthermore, R-/S-HPABA reduced carotid artery thrombosis weight. These results illustrated that R-/S-HPABA could be a potent antiplatelet aggregation and antithrombotic agent. |
| doi_str_mv | 10.1371/journal.pone.0170334 |
| format | Article |
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In this paper, the in vitro antiplatelet activities and in vivo antithrombotic effects of R-/S-HPABA were investigated, for the first time. The effects of R-/S-HPABA on platelet aggregation induced by adenosine diphosphate (ADP), collagen (COLL) and arachidonic acid (AA) were evaluated. In addition, the in vivo bleeding time, clotting time, collagen-epinephrine induced pulmonary thrombosis and common carotid artery thrombosis were also investigated in rats. R-/S-HPABA significantly inhibited ADP, COLL and AA induced platelet aggregation in rabbit platelet rich plasma in vitro compared with control group, to a degree similar to that of aspirin. Besides, R-/S-HPABA prolonged bleeding time and clotting time as well as increased the recovery rate obviously in pulmonary thrombosis. Moreover, the level of thromboxane B.sub.2 (TXB.sub.2) was decreased while the production of 6-keto-prostaglandin F1[alpha] (6-keto-PGF1[alpha]) was increased markedly by R-/S-HPABA. Furthermore, R-/S-HPABA reduced carotid artery thrombosis weight. These results illustrated that R-/S-HPABA could be a potent antiplatelet aggregation and antithrombotic agent.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0170334</identifier><language>eng</language><publisher>Public Library of Science</publisher><subject>Benzoic acid ; Comparative analysis ; Drug therapy ; Health aspects ; Hemorrhage ; Thrombosis</subject><ispartof>PloS one, 2017-01, Vol.12 (1), p.e0170334</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27923,27924</link.rule.ids></links><search><creatorcontrib>Zhang, Qili</creatorcontrib><creatorcontrib>Wang, Danlin</creatorcontrib><creatorcontrib>Zhang, Meiyan</creatorcontrib><creatorcontrib>Zhao, Yunli</creatorcontrib><creatorcontrib>Yu, Zhiguo</creatorcontrib><title>Studies on New Activities of Enantiomers of 2</title><title>PloS one</title><description>R-/S-2-(2-Hydroxypropanamido) benzoic acid (R-/S-HPABA), a marine-derived anti-inflammatory drug, however, the antiplatelet and antithrombotic effects have not been investigated. In this paper, the in vitro antiplatelet activities and in vivo antithrombotic effects of R-/S-HPABA were investigated, for the first time. The effects of R-/S-HPABA on platelet aggregation induced by adenosine diphosphate (ADP), collagen (COLL) and arachidonic acid (AA) were evaluated. In addition, the in vivo bleeding time, clotting time, collagen-epinephrine induced pulmonary thrombosis and common carotid artery thrombosis were also investigated in rats. R-/S-HPABA significantly inhibited ADP, COLL and AA induced platelet aggregation in rabbit platelet rich plasma in vitro compared with control group, to a degree similar to that of aspirin. Besides, R-/S-HPABA prolonged bleeding time and clotting time as well as increased the recovery rate obviously in pulmonary thrombosis. Moreover, the level of thromboxane B.sub.2 (TXB.sub.2) was decreased while the production of 6-keto-prostaglandin F1[alpha] (6-keto-PGF1[alpha]) was increased markedly by R-/S-HPABA. Furthermore, R-/S-HPABA reduced carotid artery thrombosis weight. These results illustrated that R-/S-HPABA could be a potent antiplatelet aggregation and antithrombotic agent.</description><subject>Benzoic acid</subject><subject>Comparative analysis</subject><subject>Drug therapy</subject><subject>Health aspects</subject><subject>Hemorrhage</subject><subject>Thrombosis</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqFj09LwzAYxoMoOKffwENPgofWJG-aNscy5hwMB254LTF503XUVJZU_fjK9FBPnp4__HjgIeSa0YxBwe72_XDwusveeo8ZZQUFECdkwhTwVHIKpyN_Ti5C2FOaQynlhKSbONgWQ9L75BE_ksrE9r2Nx8Ylc699bPtXPBwjvyRnTncBr351Srb38-3sIV2tF8tZtUobpWiqrNSMW2UF5ULQ3BnhtIYc8hdghjEoKQUp0TGnJCKXGi0Y5wzYgkvkMCW3P7ON7rBuvel9xM_Y6CGEerl5qitRlLwsGKP_sOvnv-zNiN2h7uIu9N3wfdGHMfgF0ANinQ</recordid><startdate>20170120</startdate><enddate>20170120</enddate><creator>Zhang, Qili</creator><creator>Wang, Danlin</creator><creator>Zhang, Meiyan</creator><creator>Zhao, Yunli</creator><creator>Yu, Zhiguo</creator><general>Public Library of Science</general><scope>IOV</scope><scope>ISR</scope></search><sort><creationdate>20170120</creationdate><title>Studies on New Activities of Enantiomers of 2</title><author>Zhang, Qili ; Wang, Danlin ; Zhang, Meiyan ; Zhao, Yunli ; Yu, Zhiguo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g990-9d6a12d9d4024405fc4faa3535b31c113800366ef1f96ee26aed3cffc3d726e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Benzoic acid</topic><topic>Comparative analysis</topic><topic>Drug therapy</topic><topic>Health aspects</topic><topic>Hemorrhage</topic><topic>Thrombosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Qili</creatorcontrib><creatorcontrib>Wang, Danlin</creatorcontrib><creatorcontrib>Zhang, Meiyan</creatorcontrib><creatorcontrib>Zhao, Yunli</creatorcontrib><creatorcontrib>Yu, Zhiguo</creatorcontrib><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Qili</au><au>Wang, Danlin</au><au>Zhang, Meiyan</au><au>Zhao, Yunli</au><au>Yu, Zhiguo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Studies on New Activities of Enantiomers of 2</atitle><jtitle>PloS one</jtitle><date>2017-01-20</date><risdate>2017</risdate><volume>12</volume><issue>1</issue><spage>e0170334</spage><pages>e0170334-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>R-/S-2-(2-Hydroxypropanamido) benzoic acid (R-/S-HPABA), a marine-derived anti-inflammatory drug, however, the antiplatelet and antithrombotic effects have not been investigated. In this paper, the in vitro antiplatelet activities and in vivo antithrombotic effects of R-/S-HPABA were investigated, for the first time. The effects of R-/S-HPABA on platelet aggregation induced by adenosine diphosphate (ADP), collagen (COLL) and arachidonic acid (AA) were evaluated. In addition, the in vivo bleeding time, clotting time, collagen-epinephrine induced pulmonary thrombosis and common carotid artery thrombosis were also investigated in rats. R-/S-HPABA significantly inhibited ADP, COLL and AA induced platelet aggregation in rabbit platelet rich plasma in vitro compared with control group, to a degree similar to that of aspirin. Besides, R-/S-HPABA prolonged bleeding time and clotting time as well as increased the recovery rate obviously in pulmonary thrombosis. Moreover, the level of thromboxane B.sub.2 (TXB.sub.2) was decreased while the production of 6-keto-prostaglandin F1[alpha] (6-keto-PGF1[alpha]) was increased markedly by R-/S-HPABA. Furthermore, R-/S-HPABA reduced carotid artery thrombosis weight. These results illustrated that R-/S-HPABA could be a potent antiplatelet aggregation and antithrombotic agent.</abstract><pub>Public Library of Science</pub><doi>10.1371/journal.pone.0170334</doi><tpages>e0170334</tpages></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Benzoic acid Comparative analysis Drug therapy Health aspects Hemorrhage Thrombosis |
| title | Studies on New Activities of Enantiomers of 2 |
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