Novel Neuroprotective Function of Apical-Basal Polarity Gene Crumbs in Amyloid Beta 42

Alzheimer's disease (AD, OMIM: 104300), a progressive neurodegenerative disorder with no cure to date, is caused by the generation of amyloid-beta-42 (A[beta]42) aggregates that trigger neuronal cell death by unknown mechanism(s). We have developed a transgenic Drosophila eye model where misexp...

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Veröffentlicht in:	PloS one 2013-11, Vol.8 (11), p.e78717
Hauptverfasser:	Steffensmeier, Andrew M, Tare, Meghana, Puli, Oorvashi Roy, Modi, Rohan, Nainaparampil, Jaison, Kango-Singh, Madhuri, Singh, Amit
Format:	Artikel
Sprache:	eng
Schlagworte:	Advertising executives Alzheimer's disease Cell death Drosophila Genes Genetic engineering Nervous system diseases
Online-Zugang:	Volltext
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