Higher Blood 25
Experimental data suggest a protective effect of vitamin D on breast cancer; however, epidemiologic results remain inclusive. With a Chinese population-based case-control study and meta-analysis of the observational studies, we here systematically evaluated the association of blood 25(OH)D level and...
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| Veröffentlicht in: | PloS one 2013-01, Vol.8 (1), p.e49312 |
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| creator | Chen, Peizhan Li, Mian Gu, Xiaoli Liu, Yanling Li, Xiaoguang Li, Chenglin Wang, Yuan Xie, Dong Wang, Fudi Yu, Chen Li, Jingquan Chen, Xinlei Chu, Ruiai Zhu, Jianmin Ou, Zhouluo Wang, Hui |
| description | Experimental data suggest a protective effect of vitamin D on breast cancer; however, epidemiologic results remain inclusive. With a Chinese population-based case-control study and meta-analysis of the observational studies, we here systematically evaluated the association of blood 25(OH)D level and breast cancer risk. With 593 breast cancer cases and 580 cancer-free controls from Shanghai, China, we found that 80% of the normal women had severe vitamin D deficiency (less than 20 ng/mL) and 15.2% had mild deficiency (20 to 30 ng/mL) and only 4.8% of women had sufficient vitamin D level (>30 ng/mL) while the proportion was 96.1%, 3.2% and 0.7% respectively for the breast cancer patients. Compared to those with the lowest quartile of plasma 25(OH)D level, women with highest quartile 25(OH)D level showed a significant decreased breast cancer risk (Q4 vs.Q1: OR = 0.10, 95% CI = 0.06-0.15) and every 1 ng/ml increment of plasma 25(OH)D level led to a 16% lower odds of breast cancer (OR = 0.84, 95% CI = 0.81-0.87; P |
| doi_str_mv | 10.1371/journal.pone.0049312 |
| format | Article |
| fullrecord | <record><control><sourceid>gale</sourceid><recordid>TN_cdi_gale_incontextgauss_ISR_A477937588</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A477937588</galeid><sourcerecordid>A477937588</sourcerecordid><originalsourceid>FETCH-LOGICAL-g998-206f8172bd847b8bb752de6a82de7368df32ca6ae4463af2d564e7347035ce5f3</originalsourceid><addsrcrecordid>eNqFzE9LwzAYBvAgCs4pfgEPOwkeWpO8-XucQ91gMNDhtaRN0naERJYW_PgO9FBPXt7ngefHi9AdwSUBSR4PaTxGE8rPFF2JMdNA6BmaEQ20EBTD-aRfoqucDxhzUELM0O26bzt3XDyFlOyC8mt04U3I7uY352j_8rxfrYvt7nWzWm6LVmtVUCy8IpLWVjFZq7qWnFonjDpdCUJZD7QxwjjGBBhPLRfsNDCJgTeOe5ijh5-3rQmu6mOT4uC-htaMOVeb97dqyaTUILlS_9jdx197P7GdM2Hocgrj0KeYp_AbeONXYQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Higher Blood 25</title><source>Public Library of Science (PLoS) Journals Open Access</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Chen, Peizhan ; Li, Mian ; Gu, Xiaoli ; Liu, Yanling ; Li, Xiaoguang ; Li, Chenglin ; Wang, Yuan ; Xie, Dong ; Wang, Fudi ; Yu, Chen ; Li, Jingquan ; Chen, Xinlei ; Chu, Ruiai ; Zhu, Jianmin ; Ou, Zhouluo ; Wang, Hui</creator><creatorcontrib>Chen, Peizhan ; Li, Mian ; Gu, Xiaoli ; Liu, Yanling ; Li, Xiaoguang ; Li, Chenglin ; Wang, Yuan ; Xie, Dong ; Wang, Fudi ; Yu, Chen ; Li, Jingquan ; Chen, Xinlei ; Chu, Ruiai ; Zhu, Jianmin ; Ou, Zhouluo ; Wang, Hui</creatorcontrib><description>Experimental data suggest a protective effect of vitamin D on breast cancer; however, epidemiologic results remain inclusive. With a Chinese population-based case-control study and meta-analysis of the observational studies, we here systematically evaluated the association of blood 25(OH)D level and breast cancer risk. With 593 breast cancer cases and 580 cancer-free controls from Shanghai, China, we found that 80% of the normal women had severe vitamin D deficiency (less than 20 ng/mL) and 15.2% had mild deficiency (20 to 30 ng/mL) and only 4.8% of women had sufficient vitamin D level (>30 ng/mL) while the proportion was 96.1%, 3.2% and 0.7% respectively for the breast cancer patients. Compared to those with the lowest quartile of plasma 25(OH)D level, women with highest quartile 25(OH)D level showed a significant decreased breast cancer risk (Q4 vs.Q1: OR = 0.10, 95% CI = 0.06-0.15) and every 1 ng/ml increment of plasma 25(OH)D level led to a 16% lower odds of breast cancer (OR = 0.84, 95% CI = 0.81-0.87; P<0.001). From the meta-analysis of the observational studies, we found that women with highest quantile of blood 25(OH)D level was associated with a significantly reduced breast cancer risk compared to those with lowest quantile of blood 25(OH)D level for the 11 nested case-control and retrospective studies (pooled OR = 0.86, 95% CI = 0.75-1.00) and 10 case-control studies (7 population based, OR = 0.35, 95% CI = 0.24-0.52; 3 hospital based, OR = 0.08, 95% CI = 0.02-0.33). These results suggest that vitamin D may have a chemo-preventive effect against breast cancer.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0049312</identifier><language>eng</language><publisher>Public Library of Science</publisher><subject>Breast cancer ; Cancer prevention ; Cancer research ; Health aspects ; Risk factors ; Vitamin D</subject><ispartof>PloS one, 2013-01, Vol.8 (1), p.e49312</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,866,27933,27934</link.rule.ids></links><search><creatorcontrib>Chen, Peizhan</creatorcontrib><creatorcontrib>Li, Mian</creatorcontrib><creatorcontrib>Gu, Xiaoli</creatorcontrib><creatorcontrib>Liu, Yanling</creatorcontrib><creatorcontrib>Li, Xiaoguang</creatorcontrib><creatorcontrib>Li, Chenglin</creatorcontrib><creatorcontrib>Wang, Yuan</creatorcontrib><creatorcontrib>Xie, Dong</creatorcontrib><creatorcontrib>Wang, Fudi</creatorcontrib><creatorcontrib>Yu, Chen</creatorcontrib><creatorcontrib>Li, Jingquan</creatorcontrib><creatorcontrib>Chen, Xinlei</creatorcontrib><creatorcontrib>Chu, Ruiai</creatorcontrib><creatorcontrib>Zhu, Jianmin</creatorcontrib><creatorcontrib>Ou, Zhouluo</creatorcontrib><creatorcontrib>Wang, Hui</creatorcontrib><title>Higher Blood 25</title><title>PloS one</title><description>Experimental data suggest a protective effect of vitamin D on breast cancer; however, epidemiologic results remain inclusive. With a Chinese population-based case-control study and meta-analysis of the observational studies, we here systematically evaluated the association of blood 25(OH)D level and breast cancer risk. With 593 breast cancer cases and 580 cancer-free controls from Shanghai, China, we found that 80% of the normal women had severe vitamin D deficiency (less than 20 ng/mL) and 15.2% had mild deficiency (20 to 30 ng/mL) and only 4.8% of women had sufficient vitamin D level (>30 ng/mL) while the proportion was 96.1%, 3.2% and 0.7% respectively for the breast cancer patients. Compared to those with the lowest quartile of plasma 25(OH)D level, women with highest quartile 25(OH)D level showed a significant decreased breast cancer risk (Q4 vs.Q1: OR = 0.10, 95% CI = 0.06-0.15) and every 1 ng/ml increment of plasma 25(OH)D level led to a 16% lower odds of breast cancer (OR = 0.84, 95% CI = 0.81-0.87; P<0.001). From the meta-analysis of the observational studies, we found that women with highest quantile of blood 25(OH)D level was associated with a significantly reduced breast cancer risk compared to those with lowest quantile of blood 25(OH)D level for the 11 nested case-control and retrospective studies (pooled OR = 0.86, 95% CI = 0.75-1.00) and 10 case-control studies (7 population based, OR = 0.35, 95% CI = 0.24-0.52; 3 hospital based, OR = 0.08, 95% CI = 0.02-0.33). These results suggest that vitamin D may have a chemo-preventive effect against breast cancer.</description><subject>Breast cancer</subject><subject>Cancer prevention</subject><subject>Cancer research</subject><subject>Health aspects</subject><subject>Risk factors</subject><subject>Vitamin D</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqFzE9LwzAYBvAgCs4pfgEPOwkeWpO8-XucQ91gMNDhtaRN0naERJYW_PgO9FBPXt7ngefHi9AdwSUBSR4PaTxGE8rPFF2JMdNA6BmaEQ20EBTD-aRfoqucDxhzUELM0O26bzt3XDyFlOyC8mt04U3I7uY352j_8rxfrYvt7nWzWm6LVmtVUCy8IpLWVjFZq7qWnFonjDpdCUJZD7QxwjjGBBhPLRfsNDCJgTeOe5ijh5-3rQmu6mOT4uC-htaMOVeb97dqyaTUILlS_9jdx197P7GdM2Hocgrj0KeYp_AbeONXYQ</recordid><startdate>20130130</startdate><enddate>20130130</enddate><creator>Chen, Peizhan</creator><creator>Li, Mian</creator><creator>Gu, Xiaoli</creator><creator>Liu, Yanling</creator><creator>Li, Xiaoguang</creator><creator>Li, Chenglin</creator><creator>Wang, Yuan</creator><creator>Xie, Dong</creator><creator>Wang, Fudi</creator><creator>Yu, Chen</creator><creator>Li, Jingquan</creator><creator>Chen, Xinlei</creator><creator>Chu, Ruiai</creator><creator>Zhu, Jianmin</creator><creator>Ou, Zhouluo</creator><creator>Wang, Hui</creator><general>Public Library of Science</general><scope>IOV</scope><scope>ISR</scope></search><sort><creationdate>20130130</creationdate><title>Higher Blood 25</title><author>Chen, Peizhan ; Li, Mian ; Gu, Xiaoli ; Liu, Yanling ; Li, Xiaoguang ; Li, Chenglin ; Wang, Yuan ; Xie, Dong ; Wang, Fudi ; Yu, Chen ; Li, Jingquan ; Chen, Xinlei ; Chu, Ruiai ; Zhu, Jianmin ; Ou, Zhouluo ; Wang, Hui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g998-206f8172bd847b8bb752de6a82de7368df32ca6ae4463af2d564e7347035ce5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Breast cancer</topic><topic>Cancer prevention</topic><topic>Cancer research</topic><topic>Health aspects</topic><topic>Risk factors</topic><topic>Vitamin D</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Peizhan</creatorcontrib><creatorcontrib>Li, Mian</creatorcontrib><creatorcontrib>Gu, Xiaoli</creatorcontrib><creatorcontrib>Liu, Yanling</creatorcontrib><creatorcontrib>Li, Xiaoguang</creatorcontrib><creatorcontrib>Li, Chenglin</creatorcontrib><creatorcontrib>Wang, Yuan</creatorcontrib><creatorcontrib>Xie, Dong</creatorcontrib><creatorcontrib>Wang, Fudi</creatorcontrib><creatorcontrib>Yu, Chen</creatorcontrib><creatorcontrib>Li, Jingquan</creatorcontrib><creatorcontrib>Chen, Xinlei</creatorcontrib><creatorcontrib>Chu, Ruiai</creatorcontrib><creatorcontrib>Zhu, Jianmin</creatorcontrib><creatorcontrib>Ou, Zhouluo</creatorcontrib><creatorcontrib>Wang, Hui</creatorcontrib><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Peizhan</au><au>Li, Mian</au><au>Gu, Xiaoli</au><au>Liu, Yanling</au><au>Li, Xiaoguang</au><au>Li, Chenglin</au><au>Wang, Yuan</au><au>Xie, Dong</au><au>Wang, Fudi</au><au>Yu, Chen</au><au>Li, Jingquan</au><au>Chen, Xinlei</au><au>Chu, Ruiai</au><au>Zhu, Jianmin</au><au>Ou, Zhouluo</au><au>Wang, Hui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Higher Blood 25</atitle><jtitle>PloS one</jtitle><date>2013-01-30</date><risdate>2013</risdate><volume>8</volume><issue>1</issue><spage>e49312</spage><pages>e49312-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Experimental data suggest a protective effect of vitamin D on breast cancer; however, epidemiologic results remain inclusive. With a Chinese population-based case-control study and meta-analysis of the observational studies, we here systematically evaluated the association of blood 25(OH)D level and breast cancer risk. With 593 breast cancer cases and 580 cancer-free controls from Shanghai, China, we found that 80% of the normal women had severe vitamin D deficiency (less than 20 ng/mL) and 15.2% had mild deficiency (20 to 30 ng/mL) and only 4.8% of women had sufficient vitamin D level (>30 ng/mL) while the proportion was 96.1%, 3.2% and 0.7% respectively for the breast cancer patients. Compared to those with the lowest quartile of plasma 25(OH)D level, women with highest quartile 25(OH)D level showed a significant decreased breast cancer risk (Q4 vs.Q1: OR = 0.10, 95% CI = 0.06-0.15) and every 1 ng/ml increment of plasma 25(OH)D level led to a 16% lower odds of breast cancer (OR = 0.84, 95% CI = 0.81-0.87; P<0.001). From the meta-analysis of the observational studies, we found that women with highest quantile of blood 25(OH)D level was associated with a significantly reduced breast cancer risk compared to those with lowest quantile of blood 25(OH)D level for the 11 nested case-control and retrospective studies (pooled OR = 0.86, 95% CI = 0.75-1.00) and 10 case-control studies (7 population based, OR = 0.35, 95% CI = 0.24-0.52; 3 hospital based, OR = 0.08, 95% CI = 0.02-0.33). These results suggest that vitamin D may have a chemo-preventive effect against breast cancer.</abstract><pub>Public Library of Science</pub><doi>10.1371/journal.pone.0049312</doi><tpages>e49312</tpages></addata></record> |
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| subjects | Breast cancer Cancer prevention Cancer research Health aspects Risk factors Vitamin D |
| title | Higher Blood 25 |
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