Monoallelic deletion of the microRNA biogenesis gene Dgcr8 produces deficits in the development of excitatory synaptic transmission in the prefrontal cortex

Neuronal phenotypes associated with hemizygosity of individual genes within the 22q11.2 deletion syndrome locus hold potential towards understanding the pathogenesis of schizophrenia and autism. Included among these genes is Dgcr8, which encodes an RNA-binding protein required for microRNA biogenesi...

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Veröffentlicht in:	Neural Development 2011, Vol.6, p.11
Hauptverfasser:	Schofield, Claude M, Hsu, Ruby, Barker, Alison J, Gertz, Caitlyn C, Blelloch, Robert, Ullian, Erik M
Format:	Report
Sprache:	eng
Schlagworte:	Genetic aspects MicroRNA Nervous system diseases Neural transmission Physiological aspects Prefrontal cortex Risk factors
Online-Zugang:	Volltext
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