Quantifying transmission dynamics of acute hepatitis C virus infections in a heterogeneous population using sequence data
Opioid substitution and syringes exchange programs have drastically reduced hepatitis C virus (HCV) spread in France but HCV sexual transmission in men having sex with men (MSM) has recently arisen as a significant public health concern. The fact that the virus is transmitting in a heterogeneous pop...
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| Veröffentlicht in: | PLoS pathogens 2021-09, Vol.17 (9), p.e1009916-e1009916, Article 1009916 |
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| creator | Danesh, Gonche Virlogeux, Victor Ramiere, Christophe Charre, Caroline Cotte, Laurent Alizon, Samuel |
| description | Opioid substitution and syringes exchange programs have drastically reduced hepatitis C virus (HCV) spread in France but HCV sexual transmission in men having sex with men (MSM) has recently arisen as a significant public health concern. The fact that the virus is transmitting in a heterogeneous population, with different transmission routes, makes prevalence and incidence rates poorly informative. However, additional insights can be gained by analyzing virus phylogenies inferred from dated genetic sequence data. By combining a phylodynamics approach based on Approximate Bayesian Computation (ABC) and an original transmission model, we estimate key epidemiological parameters of an ongoing HCV epidemic among MSMs in Lyon (France). We show that this new epidemic is largely independent of the previously observed non-MSM HCV epidemics and that its doubling time is ten times lower (0.44 years versus 4.37 years). These results have practical implications for HCV control and illustrate the additional information provided by virus genomics in public health. |
| doi_str_mv | 10.1371/journal.ppat.1009916 |
| format | Article |
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Places</topic><topic>Phylogeny</topic><topic>Population</topic><topic>Populations and Evolution</topic><topic>Public health</topic><topic>Quantitative Methods</topic><topic>Risk factors</topic><topic>Santé publique et épidémiologie</topic><topic>Science & Technology</topic><topic>Sexual Behavior</topic><topic>Statistics</topic><topic>Symbiosis</topic><topic>Syringes</topic><topic>Systematics, Phylogenetics and taxonomy</topic><topic>Virology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Danesh, Gonche</creatorcontrib><creatorcontrib>Virlogeux, Victor</creatorcontrib><creatorcontrib>Ramiere, Christophe</creatorcontrib><creatorcontrib>Charre, Caroline</creatorcontrib><creatorcontrib>Cotte, Laurent</creatorcontrib><creatorcontrib>Alizon, Samuel</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index 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| subjects | Bayesian analysis Biodiversity Biodiversity and Ecology Biology and Life Sciences Blood transfusions Cocaine Computer and Information Sciences Computer Science Disease transmission Drug use Ecology, environment Ecosystems Environmental Sciences Epidemics Epidemiologic methods Epidemiology Female France - epidemiology Genetics Genomics Harm reduction Health Health aspects Hepacivirus - genetics Hepatitis Hepatitis C Hepatitis C - epidemiology Hepatitis C - transmission HIV Homosexuality, Male Human immunodeficiency virus Humans Infections Life Sciences Life Sciences & Biomedicine Male Medicine and Health Sciences Methods Microbiology Microbiology and Parasitology Modeling and Simulation MSM (Men who have sex with men) Narcotics Opioids Parasitology Patients People and Places Phylogeny Population Populations and Evolution Public health Quantitative Methods Risk factors Santé publique et épidémiologie Science & Technology Sexual Behavior Statistics Symbiosis Syringes Systematics, Phylogenetics and taxonomy Virology Viruses |
| title | Quantifying transmission dynamics of acute hepatitis C virus infections in a heterogeneous population using sequence data |
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