Combined presentation and immunogenicity analysis reveals a recurrent RAS.Q61K neoantigen in melanoma

Neoantigens are now recognized drivers of the antitumor immune response. Recurrent neoantigens, shared among groups of patients, have thus become increasingly coveted therapeutic targets. Here, we report on the data-driven identification of a robustly presented, immunogenic neoantigen that is derive...

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Veröffentlicht in:	The Journal of clinical investigation 2021-10, Vol.131 (20)
Hauptverfasser:	Peri, Aviyah, Greenstein, Erez, Alon, Michal, Pai, Joy A, Dingjan, Tamir, Reich-Zeliger, Shlomit, Barnea, Eilon, Barbolin, Chaya, Levy, Ronen, Arnedo-Pac, Claudia, Kalaora, Shelly, Dassa, Bareket, Feldmesser, Ester, Shang, Ping, Greenberg, Polina, Levin, Yishai, Benedek, Gil, Levesque, Mitchell P, Adams, David J, Lotem, Michal, Wilmott, James S, Scolyer, Richard A, Jönsson, Göran B, Admon, Arie, Rosenberg, Steven A, Cohen, Cyrille J, Niv, Masha Y, Lopez-Bigas, Nuria, Satpathy, Ansuman T, Friedman, Nir, Samuels, Yardena
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Neoplasm - immunology Cancer and Oncology Cancer och onkologi Cell Line, Tumor Clinical Medicine Diagnosis Genetic aspects Guanosine triphosphatase Health aspects Histocompatibility antigens HLA histocompatibility antigens HLA-A Antigens - immunology Humans Identification and classification Immune response Klinisk medicin Lymphocytes, Tumor-Infiltrating - immunology Medical and Health Sciences Medicin och hälsovetenskap Melanoma Melanoma - immunology ras Proteins - genetics ras Proteins - immunology Receptors, Antigen, T-Cell - immunology Tumor antigens
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