In utero exposure to protease inhibitor-based antiretroviral regimens delays growth and developmental milestones in mice

Antiretroviral therapy (ART) in pregnancy has dramatically reduced HIV vertical transmission rates. Consequently, there is a growing number of children that are HIV exposed uninfected (CHEUs). Studies suggest that CHEUs exposed in utero to ART may experience developmental delays compared to their pe...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2020-11, Vol.15 (11), p.e0242513, Article 0242513
Hauptverfasser:	Sarkar, Ambalika, Balogun, Kayode, Lenis, Monica S. Guzman, Acosta, Sebastian, Mountid, Howard T., Serghides, Lena
Format:	Artikel
Sprache:	eng
Schlagworte:	Abacavir Age Animal cognition Animals Anti-HIV Agents - administration & dosage Antiretroviral agents Antiretroviral drugs Antiretroviral therapy Atazanavir Sulfate - administration & dosage Atazanavir Sulfate - toxicity Aversion Biology and Life Sciences Child development Cliffs Complications and side effects Developmental delay Developmental Disabilities - chemically induced Dideoxynucleosides - administration & dosage Dideoxynucleosides - toxicity Disease transmission Ear Emtricitabine Emtricitabine - administration & dosage Emtricitabine - toxicity Enzyme inhibitors Exploratory Behavior - drug effects Exposure Female Females Fetal Growth Retardation - chemically induced Field tests Geotaxis Growth Disorders - chemically induced Hand Strength Health aspects Health care networks Highly active antiretroviral therapy HIV HIV Protease Inhibitors - administration & dosage HIV Protease Inhibitors - toxicity Homing Behavior - drug effects Hospitals Human immunodeficiency virus Infants Intrauterine exposure Juveniles Laboratories Lamivudine Lamivudine - administration & dosage Lamivudine - toxicity Male Males Medicine and Health Sciences Mice Mice, Inbred C57BL Multidisciplinary Sciences Neonates Offspring Open-field behavior Pediatric research Performance assessment Perinatal exposure Physiological aspects Pregnancy Prenatal drug exposure Prenatal Exposure Delayed Effects Protease inhibitors Proteinase inhibitors Random Allocation Reflex, Abnormal Reflex, Righting - drug effects Reflexes Risk factors Rooting Science & Technology Science & Technology - Other Topics Sensation Disorders - chemically induced Social Sciences Taxis Response - drug effects Tenofovir Tenofovir - administration & dosage Tenofovir - toxicity Vestibular system
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!