Treatment outcomes of Nigerian patients with tuberculosis: A retrospective 25-year review in a regional medical center
Introduction Tuberculosis (TB) remains a global health challenge and leading infectious killer worldwide. The need for continuous evaluation of TB treatment outcomes becomes more imperative in the midst of a global economic meltdown substantially impacting resource-limited-settings. Methods This stu...
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| creator | Alao, Michael A. Maroushek, Stacene R. Chan, Yiong Huak Asinobi, Adanze O. Slusher, Tina M. Gbadero, Daniel A. |
| description | Introduction
Tuberculosis (TB) remains a global health challenge and leading infectious killer worldwide. The need for continuous evaluation of TB treatment outcomes becomes more imperative in the midst of a global economic meltdown substantially impacting resource-limited-settings.
Methods
This study retrospectively reviewed 25-years of treatment outcomes in 3,384 patients who were managed for TB at a tertiary hospital in Nigeria. Confirmed TB cases were given directly observed therapy of a short-course treatment regimen and monitored for clinical response.
Results
Out of 1,146,560 patients screened, there were 24,330 (2.1%) presumptive and 3,384 (13.9%) confirmed TB cases. The patients' mean age was 35.8 years (0.33-101 years). There were 1,902 (56.2%) male, 332(9.8%) pediatric, and 2,878 (85%) pulmonary TB cases.
The annual mean measured treatment outcomes were as follows: adherence, 91.4(+/- 5.8) %; successful outcome, 75.3(+/- 8.8) % potentially unsatisfactory outcome, 14.8(+/- 7.2) %; and mortality 10.0(+/- 3.6) %.
Female, extra-pulmonary TB (EPTB), newly diagnosed, and relapsed patients compliant with treatment had successful outcomes. Adulthood and HIV infection were mortality risk factors.
Conclusion
The mean annual successful treatment outcome is 75.3(+/- 8.8) %. Female, pediatric, EPTB, new, and relapsed patients were predisposed to successful treatment outcomes. Lessons learned will guide future program modifications. |
| doi_str_mv | 10.1371/journal.pone.0239225 |
| format | Article |
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Tuberculosis (TB) remains a global health challenge and leading infectious killer worldwide. The need for continuous evaluation of TB treatment outcomes becomes more imperative in the midst of a global economic meltdown substantially impacting resource-limited-settings.
Methods
This study retrospectively reviewed 25-years of treatment outcomes in 3,384 patients who were managed for TB at a tertiary hospital in Nigeria. Confirmed TB cases were given directly observed therapy of a short-course treatment regimen and monitored for clinical response.
Results
Out of 1,146,560 patients screened, there were 24,330 (2.1%) presumptive and 3,384 (13.9%) confirmed TB cases. The patients' mean age was 35.8 years (0.33-101 years). There were 1,902 (56.2%) male, 332(9.8%) pediatric, and 2,878 (85%) pulmonary TB cases.
The annual mean measured treatment outcomes were as follows: adherence, 91.4(+/- 5.8) %; successful outcome, 75.3(+/- 8.8) % potentially unsatisfactory outcome, 14.8(+/- 7.2) %; and mortality 10.0(+/- 3.6) %.
Female, extra-pulmonary TB (EPTB), newly diagnosed, and relapsed patients compliant with treatment had successful outcomes. Adulthood and HIV infection were mortality risk factors.
Conclusion
The mean annual successful treatment outcome is 75.3(+/- 8.8) %. Female, pediatric, EPTB, new, and relapsed patients were predisposed to successful treatment outcomes. Lessons learned will guide future program modifications.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0239225</identifier><identifier>PMID: 33119601</identifier><language>eng</language><publisher>SAN FRANCISCO: Public Library Science</publisher><subject>Biology and Life Sciences ; Care and treatment ; Cellular biology ; Clinical outcomes ; Contact tracing ; Demographic aspects ; Disease ; Earth Sciences ; Failure ; Global health ; Health care facilities ; Health risks ; Health services ; HIV ; Human immunodeficiency virus ; Laboratories ; Leprosy ; Medical diagnosis ; Medicine ; Medicine and Health Sciences ; Microscopy ; Mortality ; Mortality risk ; Multidisciplinary Sciences ; Patient outcomes ; Patients ; Pediatrics ; People and Places ; Public health ; Risk analysis ; Risk factors ; Science & Technology ; Science & Technology - Other Topics ; Social Sciences ; Sociodemographics ; Teaching hospitals ; Tuberculosis ; X-rays</subject><ispartof>PloS one, 2020-10, Vol.15 (10), p.e0239225-e0239225, Article 0239225</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Alao et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Alao et al 2020 Alao et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>6</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000600013600116</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c669t-ad9de05cd50bcf7370631b0e229e2203fb880c8b4779f8a1098947939e155b673</citedby><cites>FETCH-LOGICAL-c669t-ad9de05cd50bcf7370631b0e229e2203fb880c8b4779f8a1098947939e155b673</cites><orcidid>0000-0002-5798-5774</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595370/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595370/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,2104,2116,2930,23873,27931,27932,28255,53798,53800</link.rule.ids></links><search><contributor>Wingfield, Tom E.</contributor><creatorcontrib>Alao, Michael A.</creatorcontrib><creatorcontrib>Maroushek, Stacene R.</creatorcontrib><creatorcontrib>Chan, Yiong Huak</creatorcontrib><creatorcontrib>Asinobi, Adanze O.</creatorcontrib><creatorcontrib>Slusher, Tina M.</creatorcontrib><creatorcontrib>Gbadero, Daniel A.</creatorcontrib><title>Treatment outcomes of Nigerian patients with tuberculosis: A retrospective 25-year review in a regional medical center</title><title>PloS one</title><addtitle>PLOS ONE</addtitle><description>Introduction
Tuberculosis (TB) remains a global health challenge and leading infectious killer worldwide. The need for continuous evaluation of TB treatment outcomes becomes more imperative in the midst of a global economic meltdown substantially impacting resource-limited-settings.
Methods
This study retrospectively reviewed 25-years of treatment outcomes in 3,384 patients who were managed for TB at a tertiary hospital in Nigeria. Confirmed TB cases were given directly observed therapy of a short-course treatment regimen and monitored for clinical response.
Results
Out of 1,146,560 patients screened, there were 24,330 (2.1%) presumptive and 3,384 (13.9%) confirmed TB cases. The patients' mean age was 35.8 years (0.33-101 years). There were 1,902 (56.2%) male, 332(9.8%) pediatric, and 2,878 (85%) pulmonary TB cases.
The annual mean measured treatment outcomes were as follows: adherence, 91.4(+/- 5.8) %; successful outcome, 75.3(+/- 8.8) % potentially unsatisfactory outcome, 14.8(+/- 7.2) %; and mortality 10.0(+/- 3.6) %.
Female, extra-pulmonary TB (EPTB), newly diagnosed, and relapsed patients compliant with treatment had successful outcomes. Adulthood and HIV infection were mortality risk factors.
Conclusion
The mean annual successful treatment outcome is 75.3(+/- 8.8) %. Female, pediatric, EPTB, new, and relapsed patients were predisposed to successful treatment outcomes. Lessons learned will guide future program modifications.</description><subject>Biology and Life Sciences</subject><subject>Care and treatment</subject><subject>Cellular biology</subject><subject>Clinical outcomes</subject><subject>Contact tracing</subject><subject>Demographic aspects</subject><subject>Disease</subject><subject>Earth Sciences</subject><subject>Failure</subject><subject>Global health</subject><subject>Health care facilities</subject><subject>Health risks</subject><subject>Health services</subject><subject>HIV</subject><subject>Human immunodeficiency virus</subject><subject>Laboratories</subject><subject>Leprosy</subject><subject>Medical diagnosis</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Microscopy</subject><subject>Mortality</subject><subject>Mortality risk</subject><subject>Multidisciplinary Sciences</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>People and Places</subject><subject>Public health</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Science & Technology</subject><subject>Science & Technology - Other Topics</subject><subject>Social Sciences</subject><subject>Sociodemographics</subject><subject>Teaching hospitals</subject><subject>Tuberculosis</subject><subject>X-rays</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk21rFDEQxxdRbK1-A8EFQRS5M8-78YVQDh8KxYJW34ZsdvYuZW9zTbJX--2d652lJ31RlmzC5Df_mQkzRfGSkinlFf1wEcY42H66CgNMCeOaMfmoOKSas4lihD--cz4onqV0QYjktVJPiwPOKdWK0MNifR7B5iUMuQxjdmEJqQxd-d3PIXo7lCubPV6m8srnRZnHBqIb-5B8-lgelxFyDGkFLvs1lExOrsFGtK49XJV-KC2e5z5gmuUSWu9wd6gG8XnxpLN9ghe7_aj49eXz-ezb5PTs68ns-HTilNJ5YlvdApGulaRxXcUrojhtCDCmcRHeNXVNXN2IqtJdbSnRtRaV5hqolI2q-FHxaqu7wpzN7smSYULKmipWSyROtkQb7IVZRb-08doE682NIcS5sTF714MRmnRMNJ2ogQnKRc2IqFpMR4JjGB-1Pu2ijQ3Wuyk12n5PdP9m8AszD2tTSS2xOBR4uxOI4XKElM3SJwd9bwcI403eSlCNxSH6-j_0_up21NxiAX7oAsZ1G1FzrLiuBRd6k_f0Hgq_FpbeYX91Hu17Du_2HJDJ8CfP7ZiSOfn54-Hs2e999s0ddgG2z4sU-jFjD6V9UGxBh_2XInS3j0yJ2YzHv9cwm_Ewu_FAt_dbtytoQpcctraDW1dCiMJFOf4pVUjXD6dnPttNmrMwDpn_BX69IRw</recordid><startdate>20201029</startdate><enddate>20201029</enddate><creator>Alao, Michael A.</creator><creator>Maroushek, Stacene R.</creator><creator>Chan, Yiong Huak</creator><creator>Asinobi, Adanze O.</creator><creator>Slusher, Tina M.</creator><creator>Gbadero, Daniel A.</creator><general>Public Library Science</general><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-5798-5774</orcidid></search><sort><creationdate>20201029</creationdate><title>Treatment outcomes of Nigerian patients with tuberculosis: A retrospective 25-year review in a regional medical center</title><author>Alao, Michael A. ; Maroushek, Stacene R. ; Chan, Yiong Huak ; Asinobi, Adanze O. ; Slusher, Tina M. ; Gbadero, Daniel A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c669t-ad9de05cd50bcf7370631b0e229e2203fb880c8b4779f8a1098947939e155b673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biology and Life Sciences</topic><topic>Care and treatment</topic><topic>Cellular biology</topic><topic>Clinical outcomes</topic><topic>Contact tracing</topic><topic>Demographic aspects</topic><topic>Disease</topic><topic>Earth Sciences</topic><topic>Failure</topic><topic>Global health</topic><topic>Health care facilities</topic><topic>Health risks</topic><topic>Health services</topic><topic>HIV</topic><topic>Human immunodeficiency virus</topic><topic>Laboratories</topic><topic>Leprosy</topic><topic>Medical diagnosis</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Microscopy</topic><topic>Mortality</topic><topic>Mortality risk</topic><topic>Multidisciplinary Sciences</topic><topic>Patient outcomes</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>People and Places</topic><topic>Public health</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Science & Technology</topic><topic>Science & Technology - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alao, Michael A.</au><au>Maroushek, Stacene R.</au><au>Chan, Yiong Huak</au><au>Asinobi, Adanze O.</au><au>Slusher, Tina M.</au><au>Gbadero, Daniel A.</au><au>Wingfield, Tom E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment outcomes of Nigerian patients with tuberculosis: A retrospective 25-year review in a regional medical center</atitle><jtitle>PloS one</jtitle><stitle>PLOS ONE</stitle><date>2020-10-29</date><risdate>2020</risdate><volume>15</volume><issue>10</issue><spage>e0239225</spage><epage>e0239225</epage><pages>e0239225-e0239225</pages><artnum>0239225</artnum><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Introduction
Tuberculosis (TB) remains a global health challenge and leading infectious killer worldwide. The need for continuous evaluation of TB treatment outcomes becomes more imperative in the midst of a global economic meltdown substantially impacting resource-limited-settings.
Methods
This study retrospectively reviewed 25-years of treatment outcomes in 3,384 patients who were managed for TB at a tertiary hospital in Nigeria. Confirmed TB cases were given directly observed therapy of a short-course treatment regimen and monitored for clinical response.
Results
Out of 1,146,560 patients screened, there were 24,330 (2.1%) presumptive and 3,384 (13.9%) confirmed TB cases. The patients' mean age was 35.8 years (0.33-101 years). There were 1,902 (56.2%) male, 332(9.8%) pediatric, and 2,878 (85%) pulmonary TB cases.
The annual mean measured treatment outcomes were as follows: adherence, 91.4(+/- 5.8) %; successful outcome, 75.3(+/- 8.8) % potentially unsatisfactory outcome, 14.8(+/- 7.2) %; and mortality 10.0(+/- 3.6) %.
Female, extra-pulmonary TB (EPTB), newly diagnosed, and relapsed patients compliant with treatment had successful outcomes. Adulthood and HIV infection were mortality risk factors.
Conclusion
The mean annual successful treatment outcome is 75.3(+/- 8.8) %. Female, pediatric, EPTB, new, and relapsed patients were predisposed to successful treatment outcomes. Lessons learned will guide future program modifications.</abstract><cop>SAN FRANCISCO</cop><pub>Public Library Science</pub><pmid>33119601</pmid><doi>10.1371/journal.pone.0239225</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-5798-5774</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Biology and Life Sciences Care and treatment Cellular biology Clinical outcomes Contact tracing Demographic aspects Disease Earth Sciences Failure Global health Health care facilities Health risks Health services HIV Human immunodeficiency virus Laboratories Leprosy Medical diagnosis Medicine Medicine and Health Sciences Microscopy Mortality Mortality risk Multidisciplinary Sciences Patient outcomes Patients Pediatrics People and Places Public health Risk analysis Risk factors Science & Technology Science & Technology - Other Topics Social Sciences Sociodemographics Teaching hospitals Tuberculosis X-rays |
| title | Treatment outcomes of Nigerian patients with tuberculosis: A retrospective 25-year review in a regional medical center |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-04T18%3A03%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Treatment%20outcomes%20of%20Nigerian%20patients%20with%20tuberculosis:%20A%20retrospective%2025-year%20review%20in%20a%20regional%20medical%20center&rft.jtitle=PloS%20one&rft.au=Alao,%20Michael%20A.&rft.date=2020-10-29&rft.volume=15&rft.issue=10&rft.spage=e0239225&rft.epage=e0239225&rft.pages=e0239225-e0239225&rft.artnum=0239225&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0239225&rft_dat=%3Cgale_pubme%3EA639843498%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2455816285&rft_id=info:pmid/33119601&rft_galeid=A639843498&rft_doaj_id=oai_doaj_org_article_490f24bf48e2413482047db0e5ec29f8&rfr_iscdi=true |