Setting new boundaries with transcription and CTCF

How do boundary elements divide chromosomes into domains? A new study uses random genomic insertions to show how small genomic fragments can shape chromatin folding through the interplay of loop extrusion and compartmentalization. Spoiler: context matters.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature genetics 2020-10, Vol.52 (10), p.1003-1004
Hauptverfasser:	Anderson, Erika C., Nora, Elphège P.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/1511 631/208/177 631/208/191 Acetylation Agriculture Animal Genetics and Genomics Binding sites Biomedical and Life Sciences Biomedicine Boundaries Cancer Research CCCTC-Binding Factor - genetics Chromatin Chromosomes Cohesin Extrusion Gene Function Genetic research Genetic transcription Genetics & Heredity Genome Genomes Histone H3 Histones Human Genetics Life Sciences & Biomedicine Mammals News & Views news-and-views Occupancy Science & Technology Transcription initiation Transcription termination
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Beschreibung
Zusammenfassung:	How do boundary elements divide chromosomes into domains? A new study uses random genomic insertions to show how small genomic fragments can shape chromatin folding through the interplay of loop extrusion and compartmentalization. Spoiler: context matters.
ISSN:	1061-4036 1546-1718
DOI:	10.1038/s41588-020-0704-4