Rapid Nanopore Whole Genome Sequencing for Anthrax Emergency Preparedness

Human anthrax cases necessitate rapid response. We completed Bacillus anthracis nanopore whole-genome sequencing in our high-containment laboratory from a human anthrax isolate hours after receipt. The de novo assembled genome showed no evidence of known antimicrobial resistance genes or introduced...

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Veröffentlicht in:	Emerging infectious diseases 2020-02, Vol.26 (2), p.358-361
Hauptverfasser:	McLaughlin, Heather P., Bugrysheva, Julia V., Conley, Andrew B., Gulvik, Christopher A., Cherney, Blake, Kolton, Cari B., Marston, Chung K., Saile, Elke, Swaney, Erin, Lonsway, David, Gargis, Amy S., Kongphet-Tran, Thiphasone, Lascols, Christine, Michel, Pierre, Villanueva, Julie, Hoffmaster, Alex R., Gee, Jay E., Sue, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Amoxicillin Anthrax Biological weapons Characterization Ciprofloxacin Communicable diseases Disease transmission Diseases DNA sequencing Doxycycline Drug resistance Emergency preparedness Genomes Genomics Immunology Infectious Diseases Levofloxacin Life Sciences & Biomedicine Microbial drug resistance Morbidity Penicillins Prophylaxis Public health Public health movements Science & Technology Tetracyclines
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Beschreibung
Zusammenfassung:	Human anthrax cases necessitate rapid response. We completed Bacillus anthracis nanopore whole-genome sequencing in our high-containment laboratory from a human anthrax isolate hours after receipt. The de novo assembled genome showed no evidence of known antimicrobial resistance genes or introduced plasmid(s). Same-day genomic characterization enhances public health emergency response.
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid2502.191351