Reduction of Hepatic and Adipose Tissue Glucocorticoid Receptor Expression With Antisense Oligonucleotides Improves Hyperglycemia and Hyperlipidemia in Diabetic Rodents Without Causing Systemic Glucocorticoid Antagonism

Reduction of Hepatic and Adipose Tissue Glucocorticoid Receptor Expression With Antisense Oligonucleotides Improves Hyperglycemia and Hyperlipidemia in Diabetic Rodents Without Causing Systemic Glucocorticoid Antagonism Lynnetta M. Watts 1 , Vara Prasad Manchem 1 , Thomas A. Leedom 1 , Amber L. Riva...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2005-06, Vol.54 (6), p.1846-1853
Hauptverfasser:	WATTS, Lynnetta M, VARA PRASAD MANCHEM, HONG YAN ZHANG, COX, Amy L, JACOBS, Steven J, MICHAEL, M. Dodson, SLOOP, Kyle W, BHANOT, Sanjay, LEEDOM, Thomas A, RIVARD, Amber L, MCKAY, Robert A, DINGJIU BAO, NEROLADAKIS, Teri, MONIA, Brett P, BODENMILLER, Diane M, CAO, Julia Xiao-Chun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - metabolism Animals Biological and medical sciences Body fat Cardiovascular disease Case studies Dexamethasone - pharmacology Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Diabetes. Impaired glucose tolerance Disorders of blood lipids. Hyperlipoproteinemia Endocrine pancreas. Apud cells (diseases) Endocrinopathies Enzymes Etiopathogenesis. Screening. Investigations. Target tissue resistance Experiments Fatty acids Gene Expression - drug effects Glucocorticoids - metabolism Glucose Hyperglycemia Hyperglycemia - drug therapy Hyperlipidemia Hyperlipidemias - drug therapy Insulin resistance Laboratory animals Liver Liver - metabolism Lymphopenia - chemically induced Lymphopenia - physiopathology Medical sciences Metabolic diseases Metabolism Mice Mice, Obese Oligoribonucleotides, Antisense - pharmacology Pituitary Gland - drug effects Pituitary Gland - metabolism Plasma Pro-Opiomelanocortin - metabolism Rats Receptors, Glucocorticoid - metabolism RNA, Messenger - metabolism Rodents Type 2 diabetes
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