Cocaine/polydrug use in pregnancy : two-year follow-up
The impact of cocaine on pregnancy and neonatal outcome has been well documented over the past few years, but little information regarding long-term outcome of the passively exposed infants has been available. In the present study, the 2-year growth and developmental outcome for three groups of infa...
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| Veröffentlicht in: | Pediatrics (Evanston) 1992-02, Vol.89 (2), p.284-289 |
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| creator | CHASNOFF, I. J GRIFFITH, D. R FREIER, C MURRAY, J |
| description | The impact of cocaine on pregnancy and neonatal outcome has been well documented over the past few years, but little information regarding long-term outcome of the passively exposed infants has been available. In the present study, the 2-year growth and developmental outcome for three groups of infants is presented: group 1 infants exposed to cocaine and usually marijuana and/or alcohol (n = 106), group 2 infants exposed to marijuana and/or alcohol but no cocaine (n = 45), and group 3 infants exposed to no drugs during pregnancy. All three groups were similar in racial and demographic characteristics and received prenatal care through a comprehensive drug treatment and follow-up program for addicted pregnant women and their infants. The group 1 infants demonstrated significant decreases in birth weight, length, and head circumference, but by a year of age had caught up in mean length and weight compared with control infants. The group 2 infants exhibited only decreased head circumference at birth. Head size in the two drug-exposed groups remained significantly smaller than in control infants through 2 years of age. On the Bayley Scales of Infant Development, mean developmental scores of the two groups of drug-exposed infants did not vary significantly from the control group, although an increased proportion of group 1 and 2 infants scored greater than two standard deviations below the standardized mean score on both the Mental Developmental Index and the Psychomotor Developmental Index compared with the control infants. Cocaine exposure was found to be the single best predictor of head circumference. |
| doi_str_mv | 10.1542/peds.89.2.284 |
| format | Article |
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J ; GRIFFITH, D. R ; FREIER, C ; MURRAY, J</creator><creatorcontrib>CHASNOFF, I. J ; GRIFFITH, D. R ; FREIER, C ; MURRAY, J</creatorcontrib><description>The impact of cocaine on pregnancy and neonatal outcome has been well documented over the past few years, but little information regarding long-term outcome of the passively exposed infants has been available. In the present study, the 2-year growth and developmental outcome for three groups of infants is presented: group 1 infants exposed to cocaine and usually marijuana and/or alcohol (n = 106), group 2 infants exposed to marijuana and/or alcohol but no cocaine (n = 45), and group 3 infants exposed to no drugs during pregnancy. All three groups were similar in racial and demographic characteristics and received prenatal care through a comprehensive drug treatment and follow-up program for addicted pregnant women and their infants. The group 1 infants demonstrated significant decreases in birth weight, length, and head circumference, but by a year of age had caught up in mean length and weight compared with control infants. The group 2 infants exhibited only decreased head circumference at birth. Head size in the two drug-exposed groups remained significantly smaller than in control infants through 2 years of age. On the Bayley Scales of Infant Development, mean developmental scores of the two groups of drug-exposed infants did not vary significantly from the control group, although an increased proportion of group 1 and 2 infants scored greater than two standard deviations below the standardized mean score on both the Mental Developmental Index and the Psychomotor Developmental Index compared with the control infants. Cocaine exposure was found to be the single best predictor of head circumference.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.89.2.284</identifier><identifier>PMID: 1370867</identifier><identifier>CODEN: PEDIAU</identifier><language>eng</language><publisher>Elk Grove Village, IL: American Academy of Pediatrics</publisher><subject>Biological and medical sciences ; Child, Preschool ; Children ; Children of drug addicts ; Cocaine ; Cohort Studies ; Development ; Developmental Disabilities - epidemiology ; Drug abuse in pregnancy ; Drug abusers ; Drug use ; Female ; Follow-Up Studies ; Gynecology. Andrology. Obstetrics ; Head - anatomy & histology ; Health aspects ; Humans ; Infant ; Infant development ; Infant, Newborn ; Infants ; Management. Prenatal diagnosis ; Medical sciences ; Physiological aspects ; Pregnancy ; Pregnancy Complications ; Pregnancy. Fetus. Placenta ; Pregnant women ; Prenatal Exposure Delayed Effects ; Risk Factors ; Substance-Related Disorders - complications ; Time Factors</subject><ispartof>Pediatrics (Evanston), 1992-02, Vol.89 (2), p.284-289</ispartof><rights>1992 INIST-CNRS</rights><rights>COPYRIGHT 1992 American Academy of Pediatrics</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c269t-5118b35205a750094c848da46b20587b5077ada6614d121ea5e20c7fff0cb4283</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5563753$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1370867$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHASNOFF, I. J</creatorcontrib><creatorcontrib>GRIFFITH, D. R</creatorcontrib><creatorcontrib>FREIER, C</creatorcontrib><creatorcontrib>MURRAY, J</creatorcontrib><title>Cocaine/polydrug use in pregnancy : two-year follow-up</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>The impact of cocaine on pregnancy and neonatal outcome has been well documented over the past few years, but little information regarding long-term outcome of the passively exposed infants has been available. In the present study, the 2-year growth and developmental outcome for three groups of infants is presented: group 1 infants exposed to cocaine and usually marijuana and/or alcohol (n = 106), group 2 infants exposed to marijuana and/or alcohol but no cocaine (n = 45), and group 3 infants exposed to no drugs during pregnancy. All three groups were similar in racial and demographic characteristics and received prenatal care through a comprehensive drug treatment and follow-up program for addicted pregnant women and their infants. The group 1 infants demonstrated significant decreases in birth weight, length, and head circumference, but by a year of age had caught up in mean length and weight compared with control infants. The group 2 infants exhibited only decreased head circumference at birth. Head size in the two drug-exposed groups remained significantly smaller than in control infants through 2 years of age. On the Bayley Scales of Infant Development, mean developmental scores of the two groups of drug-exposed infants did not vary significantly from the control group, although an increased proportion of group 1 and 2 infants scored greater than two standard deviations below the standardized mean score on both the Mental Developmental Index and the Psychomotor Developmental Index compared with the control infants. Cocaine exposure was found to be the single best predictor of head circumference.</description><subject>Biological and medical sciences</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Children of drug addicts</subject><subject>Cocaine</subject><subject>Cohort Studies</subject><subject>Development</subject><subject>Developmental Disabilities - epidemiology</subject><subject>Drug abuse in pregnancy</subject><subject>Drug abusers</subject><subject>Drug use</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Head - anatomy & histology</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant development</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Management. Prenatal diagnosis</subject><subject>Medical sciences</subject><subject>Physiological aspects</subject><subject>Pregnancy</subject><subject>Pregnancy Complications</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Pregnant women</subject><subject>Prenatal Exposure Delayed Effects</subject><subject>Risk Factors</subject><subject>Substance-Related Disorders - complications</subject><subject>Time Factors</subject><issn>0031-4005</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM9LwzAUx4Moc06PHoUePJruJU2a1Nso_oLBLnoOaZqWSteWZGX2vzejQ08P3vfD9z0-CN0TiAlndD3Y0scyi2lMJbtASwKZxIwKfomWAAnBDIBfoxvvvwGAcUEXaEESATIVS5TmvdFNZ9dD306lG-to9DZqumhwtu50Z6boOTocezxZ7aKqb9v-iMfhFl1VuvX27jxX6Ov15TN_x9vd20e-2WJD0-yAOSGySDgFrgUHyJiRTJaapUVYSVFwEEKXOk0JKwklVnNLwYiqqsAUjMpkhZ7m3lq3VjWd6buD_TmY8IetrQq38p3aEBq6paQBxzNuXO-9s5UaXLPXblIE1MmWOtlSMlNUBVuBf5j5YSz2tvynZz0hfzzn2hvdVi4IafwfxnmaCJ4kv9HqcCs</recordid><startdate>199202</startdate><enddate>199202</enddate><creator>CHASNOFF, I. J</creator><creator>GRIFFITH, D. 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R ; FREIER, C ; MURRAY, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c269t-5118b35205a750094c848da46b20587b5077ada6614d121ea5e20c7fff0cb4283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Biological and medical sciences</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Children of drug addicts</topic><topic>Cocaine</topic><topic>Cohort Studies</topic><topic>Development</topic><topic>Developmental Disabilities - epidemiology</topic><topic>Drug abuse in pregnancy</topic><topic>Drug abusers</topic><topic>Drug use</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Head - anatomy & histology</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant development</topic><topic>Infant, Newborn</topic><topic>Infants</topic><topic>Management. Prenatal diagnosis</topic><topic>Medical sciences</topic><topic>Physiological aspects</topic><topic>Pregnancy</topic><topic>Pregnancy Complications</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Pregnant women</topic><topic>Prenatal Exposure Delayed Effects</topic><topic>Risk Factors</topic><topic>Substance-Related Disorders - complications</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHASNOFF, I. J</creatorcontrib><creatorcontrib>GRIFFITH, D. 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R</au><au>FREIER, C</au><au>MURRAY, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cocaine/polydrug use in pregnancy : two-year follow-up</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>1992-02</date><risdate>1992</risdate><volume>89</volume><issue>2</issue><spage>284</spage><epage>289</epage><pages>284-289</pages><issn>0031-4005</issn><eissn>1098-4275</eissn><coden>PEDIAU</coden><abstract>The impact of cocaine on pregnancy and neonatal outcome has been well documented over the past few years, but little information regarding long-term outcome of the passively exposed infants has been available. In the present study, the 2-year growth and developmental outcome for three groups of infants is presented: group 1 infants exposed to cocaine and usually marijuana and/or alcohol (n = 106), group 2 infants exposed to marijuana and/or alcohol but no cocaine (n = 45), and group 3 infants exposed to no drugs during pregnancy. All three groups were similar in racial and demographic characteristics and received prenatal care through a comprehensive drug treatment and follow-up program for addicted pregnant women and their infants. The group 1 infants demonstrated significant decreases in birth weight, length, and head circumference, but by a year of age had caught up in mean length and weight compared with control infants. The group 2 infants exhibited only decreased head circumference at birth. Head size in the two drug-exposed groups remained significantly smaller than in control infants through 2 years of age. On the Bayley Scales of Infant Development, mean developmental scores of the two groups of drug-exposed infants did not vary significantly from the control group, although an increased proportion of group 1 and 2 infants scored greater than two standard deviations below the standardized mean score on both the Mental Developmental Index and the Psychomotor Developmental Index compared with the control infants. Cocaine exposure was found to be the single best predictor of head circumference.</abstract><cop>Elk Grove Village, IL</cop><pub>American Academy of Pediatrics</pub><pmid>1370867</pmid><doi>10.1542/peds.89.2.284</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Biological and medical sciences Child, Preschool Children Children of drug addicts Cocaine Cohort Studies Development Developmental Disabilities - epidemiology Drug abuse in pregnancy Drug abusers Drug use Female Follow-Up Studies Gynecology. Andrology. Obstetrics Head - anatomy & histology Health aspects Humans Infant Infant development Infant, Newborn Infants Management. Prenatal diagnosis Medical sciences Physiological aspects Pregnancy Pregnancy Complications Pregnancy. Fetus. Placenta Pregnant women Prenatal Exposure Delayed Effects Risk Factors Substance-Related Disorders - complications Time Factors |
| title | Cocaine/polydrug use in pregnancy : two-year follow-up |
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