Captopril-induced reversible acute renal failure in an infant with coarctation of the aorta

Activation of the renin-angiotensin system has been implicated in the initiation of hypertension associated with coarctation of the aorta, with sodium and volume expansion playing a role in maintenance of the hypertension. Increase in total peripheral resistance induced by the stenosis itself also h...

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Veröffentlicht in:Pediatrics (Evanston) 1991-10, Vol.88 (4), p.816-818
Hauptverfasser: WOOD, E. G, BUNCHMAN, T. E, LYNCH, R. E
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creator WOOD, E. G
BUNCHMAN, T. E
LYNCH, R. E
description Activation of the renin-angiotensin system has been implicated in the initiation of hypertension associated with coarctation of the aorta, with sodium and volume expansion playing a role in maintenance of the hypertension. Increase in total peripheral resistance induced by the stenosis itself also has received increasing attention in the etiology of coarctation and renal vascular hypertension.1-5 To date, angiotensin-converting enzyme (ACE) inhibitors have been used to lower acutely blood pressure in patients with coarctation, as well as in "paradoxical" postoperative treatment of hypertension.2,6 We recently cared for a small infant with hypertension due to coarctation of the aorta who developed acute renal insufficiency while receiving captopril.
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subjects Acute kidney failure
Acute Kidney Injury - chemically induced
Acute Kidney Injury - complications
Acute renal failure
Aortic coarctation
Aortic Coarctation - complications
Biological and medical sciences
Captopril
Captopril - adverse effects
Captopril - therapeutic use
Cardiology. Vascular system
Case studies
Complications and side effects
Female
Humans
Hypertension - drug therapy
Hypertension - etiology
Infant, Newborn
Medical sciences
title Captopril-induced reversible acute renal failure in an infant with coarctation of the aorta
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