Modulation of [alpha]-thrombin function by distinct interactions with platelet glycoprotein Ib[alpha]

Thrombin bound to platelets contributes to stop bleeding and, in pathological conditions, may cause vascular thrombosis. We have determined the structure of platelet glycoprotein Ib[alpha] (GpIb[alpha]) bound to thrombin at 2.3 angstrom resolution and defined two sites in GpIb[alpha] that bind to ex...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2003-07, Vol.301 (5630), p.218
Hauptverfasser:	Celikel, Reha, McClintock, Richard A, Roberts, James R, Mendolicchio, G. Loredana, Ware, Jerry, Varughese, Kottayil I, Ruggeri, Zaverio M
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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