Renal Megalin mRNA Downregulation Is Associated with CKD Progression in IgA Nephropathy

Introduction: Megalin plays an important role in proximal tubule uptake of filtered proteins. Downregulation and dysfunction of megalin were previously demonstrated in IgA nephropathy (IgAN); however, its relationship to IgAN progression remains unclear. Methods: We measured renal megalin mRNA and m...

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Veröffentlicht in:	American journal of nephrology 2022-07, Vol.53 (6), p.481-489
Hauptverfasser:	Wen, Lu, Wang, Xiaoyang, Ji, Fengping, Wen, Jianguo, Zhao, Zhanzheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Chronic kidney failure Complications and side effects Development and progression Health aspects IgA glomerulonephritis Messenger RNA Patient-Oriented, Translational Research: Research Article Risk factors
Online-Zugang:	Volltext
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