Soluble PD-L1 Concentration Is Proportional to the Expression of PD-L1 in Tissue and Is Associated with a Poor Prognosis in Esophageal Squamous Cell Carcinoma
Introduction: We determined the soluble programmed cell death-1 ligand-1 (sPD-L1) concentration in patients with esophageal squamous cell carcinoma (ESCC), and confirmed the PD-L1 expression in resected specimens. Methods: Blood samples were collected from 73 patients with histologically proven ESCC...
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| Veröffentlicht in: | Oncology 2022-01, Vol.100 (1), p.39-47 |
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| creator | Shiraishi, Tadashi Toyozumi, Takeshi Sakata, Haruhito Murakami, Kentaro Kano, Masayuki Matsumoto, Yasunori Yokoyama, Masaya Okada, Koichiro Kamata, Toshiki Ryuzaki, Takahiro Kinoshita, Kazuya Hirasawa, Soichiro Matsubara, Hisahiro |
| description | Introduction: We determined the soluble programmed cell death-1 ligand-1 (sPD-L1) concentration in patients with esophageal squamous cell carcinoma (ESCC), and confirmed the PD-L1 expression in resected specimens. Methods: Blood samples were collected from 73 patients with histologically proven ESCC. The serum levels of sPD-L1 were measured using an enzyme-linked immunosorbent assay. The correlations between the sPD-L1 concentration and the expression of PD-L1 in tumor specimens and tumor depth, lymph node metastasis, disease stage, and various laboratory data were assessed. Results: sPD-L1 levels in patients with high PD-L1 expression levels in tumor tissue were significantly higher than in patients with low PD-L1 expression levels (p = 0.042). The OS of the sPD-L1-high group was significantly worse than that of the low group (p = 0.028). Similarly, patients in whom a tissue specimen was PD-L1-positive group showed significantly poorer OS. Conclusion: The sPD-L1 concentration was correlated with the PD-L1 expression in tissues. Patients with PD-L1-positive tissue specimens showed significantly higher sPD-L1 levels in comparison to PD-L1-negative cases. Furthermore, patients with high sPD-L1 expression levels had a significantly worse prognosis than those with low sPD-L1 expression levels, and patients with a PD-L1-positive tissue specimen had a significantly worse prognosis than patients in whom the tissue specimen showed a low PD-L1 expression level. |
| doi_str_mv | 10.1159/000518740 |
| format | Article |
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Methods: Blood samples were collected from 73 patients with histologically proven ESCC. The serum levels of sPD-L1 were measured using an enzyme-linked immunosorbent assay. The correlations between the sPD-L1 concentration and the expression of PD-L1 in tumor specimens and tumor depth, lymph node metastasis, disease stage, and various laboratory data were assessed. Results: sPD-L1 levels in patients with high PD-L1 expression levels in tumor tissue were significantly higher than in patients with low PD-L1 expression levels (p = 0.042). The OS of the sPD-L1-high group was significantly worse than that of the low group (p = 0.028). Similarly, patients in whom a tissue specimen was PD-L1-positive group showed significantly poorer OS. Conclusion: The sPD-L1 concentration was correlated with the PD-L1 expression in tissues. Patients with PD-L1-positive tissue specimens showed significantly higher sPD-L1 levels in comparison to PD-L1-negative cases. Furthermore, patients with high sPD-L1 expression levels had a significantly worse prognosis than those with low sPD-L1 expression levels, and patients with a PD-L1-positive tissue specimen had a significantly worse prognosis than patients in whom the tissue specimen showed a low PD-L1 expression level.</description><identifier>ISSN: 0030-2414</identifier><identifier>EISSN: 1423-0232</identifier><identifier>DOI: 10.1159/000518740</identifier><identifier>PMID: 34991094</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Aged ; Animals ; Apoptosis ; B7-H1 Antigen - blood ; B7-H1 Antigen - genetics ; B7-H1 Antigen - metabolism ; Biomarkers, Tumor - blood ; Biomarkers, Tumor - metabolism ; Cancer ; Cell Line, Tumor ; Development and progression ; Esophageal cancer ; Esophageal Neoplasms - metabolism ; Esophageal Neoplasms - mortality ; Esophageal Neoplasms - pathology ; Esophageal Neoplasms - surgery ; Esophageal Squamous Cell Carcinoma - metabolism ; Esophageal Squamous Cell Carcinoma - mortality ; Esophageal Squamous Cell Carcinoma - pathology ; Esophageal Squamous Cell Carcinoma - surgery ; Female ; Health aspects ; Humans ; Male ; Methods ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Middle Aged ; Oncology, Experimental ; Prognosis ; Research Article ; Solubility ; Squamous cell carcinoma ; Survival Rate ; Xenograft Model Antitumor Assays</subject><ispartof>Oncology, 2022-01, Vol.100 (1), p.39-47</ispartof><rights>2021 S. Karger AG, Basel</rights><rights>2021 S. Karger AG, Basel.</rights><rights>COPYRIGHT 2022 S. Karger AG</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-3797ff4cd2c775edef586f1eb3ad38096dc11d9ae530b81081d83488bbb4ebd33</citedby><cites>FETCH-LOGICAL-c347t-3797ff4cd2c775edef586f1eb3ad38096dc11d9ae530b81081d83488bbb4ebd33</cites><orcidid>0000-0003-1424-3049 ; 0000-0002-1797-5176</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34991094$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shiraishi, Tadashi</creatorcontrib><creatorcontrib>Toyozumi, Takeshi</creatorcontrib><creatorcontrib>Sakata, Haruhito</creatorcontrib><creatorcontrib>Murakami, Kentaro</creatorcontrib><creatorcontrib>Kano, Masayuki</creatorcontrib><creatorcontrib>Matsumoto, Yasunori</creatorcontrib><creatorcontrib>Yokoyama, Masaya</creatorcontrib><creatorcontrib>Okada, Koichiro</creatorcontrib><creatorcontrib>Kamata, Toshiki</creatorcontrib><creatorcontrib>Ryuzaki, Takahiro</creatorcontrib><creatorcontrib>Kinoshita, Kazuya</creatorcontrib><creatorcontrib>Hirasawa, Soichiro</creatorcontrib><creatorcontrib>Matsubara, Hisahiro</creatorcontrib><title>Soluble PD-L1 Concentration Is Proportional to the Expression of PD-L1 in Tissue and Is Associated with a Poor Prognosis in Esophageal Squamous Cell Carcinoma</title><title>Oncology</title><addtitle>Oncology</addtitle><description>Introduction: We determined the soluble programmed cell death-1 ligand-1 (sPD-L1) concentration in patients with esophageal squamous cell carcinoma (ESCC), and confirmed the PD-L1 expression in resected specimens. Methods: Blood samples were collected from 73 patients with histologically proven ESCC. The serum levels of sPD-L1 were measured using an enzyme-linked immunosorbent assay. The correlations between the sPD-L1 concentration and the expression of PD-L1 in tumor specimens and tumor depth, lymph node metastasis, disease stage, and various laboratory data were assessed. Results: sPD-L1 levels in patients with high PD-L1 expression levels in tumor tissue were significantly higher than in patients with low PD-L1 expression levels (p = 0.042). The OS of the sPD-L1-high group was significantly worse than that of the low group (p = 0.028). Similarly, patients in whom a tissue specimen was PD-L1-positive group showed significantly poorer OS. Conclusion: The sPD-L1 concentration was correlated with the PD-L1 expression in tissues. Patients with PD-L1-positive tissue specimens showed significantly higher sPD-L1 levels in comparison to PD-L1-negative cases. Furthermore, patients with high sPD-L1 expression levels had a significantly worse prognosis than those with low sPD-L1 expression levels, and patients with a PD-L1-positive tissue specimen had a significantly worse prognosis than patients in whom the tissue specimen showed a low PD-L1 expression level.</description><subject>Aged</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>B7-H1 Antigen - blood</subject><subject>B7-H1 Antigen - genetics</subject><subject>B7-H1 Antigen - metabolism</subject><subject>Biomarkers, Tumor - blood</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Cancer</subject><subject>Cell Line, Tumor</subject><subject>Development and progression</subject><subject>Esophageal cancer</subject><subject>Esophageal Neoplasms - metabolism</subject><subject>Esophageal Neoplasms - mortality</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Esophageal Neoplasms - surgery</subject><subject>Esophageal Squamous Cell Carcinoma - metabolism</subject><subject>Esophageal Squamous Cell Carcinoma - mortality</subject><subject>Esophageal Squamous Cell Carcinoma - pathology</subject><subject>Esophageal Squamous Cell Carcinoma - surgery</subject><subject>Female</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Male</subject><subject>Methods</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Nude</subject><subject>Middle Aged</subject><subject>Oncology, Experimental</subject><subject>Prognosis</subject><subject>Research Article</subject><subject>Solubility</subject><subject>Squamous cell carcinoma</subject><subject>Survival Rate</subject><subject>Xenograft Model Antitumor Assays</subject><issn>0030-2414</issn><issn>1423-0232</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0kGL1DAUB_AgijuuHryLBBZED12TJm3T49AddWFgB3Y9lzR5nYm2STdp0f0yflZTOg4uLD2Upr__4-UlCL2l5JLSrPxMCMmoKDh5hlaUpywhKUufoxUhjCQpp_wMvQrhR2RFxvOX6IzxsqSk5Cv059Z1U9MB3l0lW4orZxXY0cvROIuvA955Nzg_f8kOjw6PB8Cb34OHEGbh2mPQWHxnQpgAS6vn4DoEp4wcQeNfZjxgiXfO-bne3rpgwpzYBDcc5B5i6dv7SfZuCriCrsOV9MpY18vX6EUruwBvju9z9P3L5q76lmxvvl5X622iGC_GhBVl0bZc6VQVRQYa2kzkLYWGSc0EKXOtKNWlhIyRRlAiqBaMC9E0DYdGM3aOPi51B-_uJwhj3ZugYivSQuyqTnMq0lTkgkR6sdC97KA2tnVxXGrm9bogZUnSvJjV5RMqPhp6o5yF1sT1R4EP_wUOcSbjIcSzmUcfHsNPC1TeheChrQdveukfakrq-TrUp-sQ7fvjtqamB32S_84_gncL-Cn9HvwJnPIXT_6-qbaLqAfdsr861cK1</recordid><startdate>202201</startdate><enddate>202201</enddate><creator>Shiraishi, Tadashi</creator><creator>Toyozumi, Takeshi</creator><creator>Sakata, Haruhito</creator><creator>Murakami, Kentaro</creator><creator>Kano, Masayuki</creator><creator>Matsumoto, Yasunori</creator><creator>Yokoyama, Masaya</creator><creator>Okada, Koichiro</creator><creator>Kamata, Toshiki</creator><creator>Ryuzaki, Takahiro</creator><creator>Kinoshita, Kazuya</creator><creator>Hirasawa, Soichiro</creator><creator>Matsubara, Hisahiro</creator><general>S. Karger AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1424-3049</orcidid><orcidid>https://orcid.org/0000-0002-1797-5176</orcidid></search><sort><creationdate>202201</creationdate><title>Soluble PD-L1 Concentration Is Proportional to the Expression of PD-L1 in Tissue and Is Associated with a Poor Prognosis in Esophageal Squamous Cell Carcinoma</title><author>Shiraishi, Tadashi ; Toyozumi, Takeshi ; Sakata, Haruhito ; Murakami, Kentaro ; Kano, Masayuki ; Matsumoto, Yasunori ; Yokoyama, Masaya ; Okada, Koichiro ; Kamata, Toshiki ; Ryuzaki, Takahiro ; Kinoshita, Kazuya ; Hirasawa, Soichiro ; Matsubara, Hisahiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-3797ff4cd2c775edef586f1eb3ad38096dc11d9ae530b81081d83488bbb4ebd33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aged</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>B7-H1 Antigen - blood</topic><topic>B7-H1 Antigen - genetics</topic><topic>B7-H1 Antigen - metabolism</topic><topic>Biomarkers, Tumor - blood</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Cancer</topic><topic>Cell Line, Tumor</topic><topic>Development and progression</topic><topic>Esophageal cancer</topic><topic>Esophageal Neoplasms - metabolism</topic><topic>Esophageal Neoplasms - mortality</topic><topic>Esophageal Neoplasms - pathology</topic><topic>Esophageal Neoplasms - surgery</topic><topic>Esophageal Squamous Cell Carcinoma - metabolism</topic><topic>Esophageal Squamous Cell Carcinoma - mortality</topic><topic>Esophageal Squamous Cell Carcinoma - pathology</topic><topic>Esophageal Squamous Cell Carcinoma - surgery</topic><topic>Female</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Male</topic><topic>Methods</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Nude</topic><topic>Middle Aged</topic><topic>Oncology, Experimental</topic><topic>Prognosis</topic><topic>Research Article</topic><topic>Solubility</topic><topic>Squamous cell carcinoma</topic><topic>Survival Rate</topic><topic>Xenograft Model Antitumor Assays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shiraishi, Tadashi</creatorcontrib><creatorcontrib>Toyozumi, Takeshi</creatorcontrib><creatorcontrib>Sakata, Haruhito</creatorcontrib><creatorcontrib>Murakami, Kentaro</creatorcontrib><creatorcontrib>Kano, Masayuki</creatorcontrib><creatorcontrib>Matsumoto, Yasunori</creatorcontrib><creatorcontrib>Yokoyama, Masaya</creatorcontrib><creatorcontrib>Okada, Koichiro</creatorcontrib><creatorcontrib>Kamata, Toshiki</creatorcontrib><creatorcontrib>Ryuzaki, Takahiro</creatorcontrib><creatorcontrib>Kinoshita, Kazuya</creatorcontrib><creatorcontrib>Hirasawa, Soichiro</creatorcontrib><creatorcontrib>Matsubara, Hisahiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shiraishi, Tadashi</au><au>Toyozumi, Takeshi</au><au>Sakata, Haruhito</au><au>Murakami, Kentaro</au><au>Kano, Masayuki</au><au>Matsumoto, Yasunori</au><au>Yokoyama, Masaya</au><au>Okada, Koichiro</au><au>Kamata, Toshiki</au><au>Ryuzaki, Takahiro</au><au>Kinoshita, Kazuya</au><au>Hirasawa, Soichiro</au><au>Matsubara, Hisahiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Soluble PD-L1 Concentration Is Proportional to the Expression of PD-L1 in Tissue and Is Associated with a Poor Prognosis in Esophageal Squamous Cell Carcinoma</atitle><jtitle>Oncology</jtitle><addtitle>Oncology</addtitle><date>2022-01</date><risdate>2022</risdate><volume>100</volume><issue>1</issue><spage>39</spage><epage>47</epage><pages>39-47</pages><issn>0030-2414</issn><eissn>1423-0232</eissn><abstract>Introduction: We determined the soluble programmed cell death-1 ligand-1 (sPD-L1) concentration in patients with esophageal squamous cell carcinoma (ESCC), and confirmed the PD-L1 expression in resected specimens. Methods: Blood samples were collected from 73 patients with histologically proven ESCC. The serum levels of sPD-L1 were measured using an enzyme-linked immunosorbent assay. The correlations between the sPD-L1 concentration and the expression of PD-L1 in tumor specimens and tumor depth, lymph node metastasis, disease stage, and various laboratory data were assessed. Results: sPD-L1 levels in patients with high PD-L1 expression levels in tumor tissue were significantly higher than in patients with low PD-L1 expression levels (p = 0.042). The OS of the sPD-L1-high group was significantly worse than that of the low group (p = 0.028). Similarly, patients in whom a tissue specimen was PD-L1-positive group showed significantly poorer OS. Conclusion: The sPD-L1 concentration was correlated with the PD-L1 expression in tissues. Patients with PD-L1-positive tissue specimens showed significantly higher sPD-L1 levels in comparison to PD-L1-negative cases. Furthermore, patients with high sPD-L1 expression levels had a significantly worse prognosis than those with low sPD-L1 expression levels, and patients with a PD-L1-positive tissue specimen had a significantly worse prognosis than patients in whom the tissue specimen showed a low PD-L1 expression level.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>34991094</pmid><doi>10.1159/000518740</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-1424-3049</orcidid><orcidid>https://orcid.org/0000-0002-1797-5176</orcidid></addata></record> |
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| ispartof | Oncology, 2022-01, Vol.100 (1), p.39-47 |
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| source | Karger Journals; MEDLINE |
| subjects | Aged Animals Apoptosis B7-H1 Antigen - blood B7-H1 Antigen - genetics B7-H1 Antigen - metabolism Biomarkers, Tumor - blood Biomarkers, Tumor - metabolism Cancer Cell Line, Tumor Development and progression Esophageal cancer Esophageal Neoplasms - metabolism Esophageal Neoplasms - mortality Esophageal Neoplasms - pathology Esophageal Neoplasms - surgery Esophageal Squamous Cell Carcinoma - metabolism Esophageal Squamous Cell Carcinoma - mortality Esophageal Squamous Cell Carcinoma - pathology Esophageal Squamous Cell Carcinoma - surgery Female Health aspects Humans Male Methods Mice Mice, Inbred BALB C Mice, Nude Middle Aged Oncology, Experimental Prognosis Research Article Solubility Squamous cell carcinoma Survival Rate Xenograft Model Antitumor Assays |
| title | Soluble PD-L1 Concentration Is Proportional to the Expression of PD-L1 in Tissue and Is Associated with a Poor Prognosis in Esophageal Squamous Cell Carcinoma |
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