To Breathe or Not to Breathe: The Role of Oxygen in Bone Marrow-Derived Mesenchymal Stromal Cell Senescence

To Breathe or Not to Breathe: The Role of Oxygen in Bone Marrow-Derived Mesenchymal Stromal Cell Senescence

Stem cell-based cellular therapy is a promising tool for the treatment of pathological conditions with underlying severe tissue damage or malfunction like in chronic cardiovascular, musculoskeletal, or inflammatory conditions. One of the biggest technical challenges of the use of natural stem cells,...

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Veröffentlicht in:Stem cells international 2021, Vol.2021, p.8899756-10, Article 8899756
Hauptverfasser: Gala, Dhir Niren, Fabian, Zsolt
Format: Artikel
Sprache:eng
Schlagworte:
Adaptation
Binding sites
Bone marrow
Cell & Tissue Engineering
Cell Biology
Chemokines
Cyclin-dependent kinases
Cytokines
Fibroblasts
Gene expression
Hypoxia
Inflammation
Kinases
Life Sciences & Biomedicine
Literature reviews
Mesenchyme
Morphology
Physiology
Review
Science & Technology
Senescence
Stem cells
Stromal cells
Transplantation
Vascular endothelial growth factor
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description Stem cell-based cellular therapy is a promising tool for the treatment of pathological conditions with underlying severe tissue damage or malfunction like in chronic cardiovascular, musculoskeletal, or inflammatory conditions. One of the biggest technical challenges of the use of natural stem cells, however, is the prevention of their premature senescence during therapeutical manipulations. Culturing stem cells under hypoxic conditions is believed to be a possible route to fulfill this goal. Here, we review current literature data on the effects of hypoxia on bone marrow-derived mesenchymal stromal cells, one of the most popular tools of practical cellular therapy, in the context of their senescence.
doi_str_mv 10.1155/2021/8899756
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subjects Adaptation
Binding sites
Bone marrow
Cell & Tissue Engineering
Cell Biology
Chemokines
Cyclin-dependent kinases
Cytokines
Fibroblasts
Gene expression
Hypoxia
Inflammation
Kinases
Life Sciences & Biomedicine
Literature reviews
Mesenchyme
Morphology
Physiology
Review
Science & Technology
Senescence
Stem cells
Stromal cells
Transplantation
Vascular endothelial growth factor
title To Breathe or Not to Breathe: The Role of Oxygen in Bone Marrow-Derived Mesenchymal Stromal Cell Senescence
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