The Nonantibiotic Macrolide EM900 Attenuates House Dust Mite-Induced Airway Inflammation in a Mouse Model of Obesity-Associated Asthma

Introduction: Obesity-associated asthma is characterized by type 2-low airway inflammation. We previously showed that EM900, which is a 12-membered nonantibiotic macrolide, suppressed airway inflammation in a mouse model of asthma exacerbation. The aim of this study was to clarify the effects of EM9...

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Veröffentlicht in:	International archives of allergy and immunology 2020-09, Vol.181 (9), p.665-674
Hauptverfasser:	Sadamatsu, Hironori, Takahashi, Koichiro, Tashiro, Hiroki, Kurihara, Yuki, Kato, Go, Uchida, Masaru, Noguchi, Yoshihiko, Kurata, Keigo, Ōmura, Satoshi, Sunazuka, Toshiaki, Kimura, Shinya, Sueoka-Aragane, Naoko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Asthmatic Agents - therapeutic use Antigens, Dermatophagoides - immunology Asthma Asthma - drug therapy Complications and side effects Diet, High-Fat Disease Models, Animal Drug therapy Erythromycin - analogs & derivatives Erythromycin - therapeutic use Experimental Allergy – Research Article Humans Inflammation Interleukin-17 - metabolism Lung - immunology Macrolide antibiotics Mice Mice, Inbred BALB C Obesity Obesity - drug therapy Pneumonia - drug therapy Pyroglyphidae Testing Th2 Cells - immunology
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